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Capturing the birth of a synapse
Date:5/27/2009

The findings, he added, reflect a clearer understanding of how synapses form, providing a roadmap for research that someday may lead to new therapies or a cure for autism, a brain development disorder that affects a person's social and communication abilities. The disorder affects 1 in every 150 American children, according to the Autism Society of America.

The new window opened by Washbourne's team captures the essence of synapse development, which occurs over and over among the estimated 100 billion neurons that make some 100 trillion synapses in a single human being. That leaves a lot of room for errors in the DNA-driven instructions for synthesizing molecules responsible for synapse formation, Washbourne said.

"Basically," Washbourne said, "we have found mechanisms by which two very important molecules, NMDA and PSD-95, are brought to a newly forming synapse."


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Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert  

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