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Capillaries will measure diffusion and help in more efficient medical treatment
Date:2/12/2014

twenty times higher. The time needed to determine the diffusion coefficient was reduced down to three minutes, and the accuracy of measurements increased more than five times.

The shortening of analysis time is important from the medical practitioner's point of view. The determination of a drug dose optimal for a specific patient requires not one, but three measurements. "First, we have to introduce drug molecules into the capillary and to determine the rate of their diffusion. Then we measure the diffusion of protein, with which the drug is to bind, for instance, albumin. In the third measurement we inject both the drug and the protein, with which the drug interacts, into the capillary filled with the same protein. Only the comparison of the results allows to find how efficiently the drug will bind to the protein in patient's blood", explains Aldona Majcher, a doctoral student at the IPC PAS.

The patent-pending method for determining of the diffusion coefficient in fluids is fast, versatile, and simple. It does not require any expensive and complicated measurement equipment, and so it has a chance to get popularised and end up in many hospitals and health centres, as well as chemical and biological laboratories. The experiments in the IPC PAS have shown that the method has proven in measurements with salts, amino acids, peptides, proteins und drugs.


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Contact: Robert Holyst
rholyst@ichf.edu.pl
Institute of Physical Chemistry of the Polish Academy of Sciences
Source:Eurekalert  

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