Navigation Links
Cantilever sensory array: The Rosetta Stone for antibiotic resistance?
Date:10/25/2013

On October 25, JoVE, the Journal of Visualized Experiments will publish a novel technique to confront the problem of antibiotic resistance. According to Dr. Joseph Ndieyira, one of the developers involved in the technique, "The use of this technology will allow scientists to understand how antibiotics work, how bacteria develop resistance, and what molecular mechanisms could be exploited to get around their defense mechanisms."

"We report a novel, nanomechanical approach to investigate the workings of vancomycin ... one of the last powerful antibiotics used to combat increasingly-resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA)," said Ndieyira.

Using tiny cantilevers (or beams) no wider then a human hair, Ndieyira and his colleagues take advantage of the cellular stress that antibiotics, when effective, impose on a target bacteria's cell wall. Such stress in turn causes the cantilevers to bend. Using lasers, the bending can then be measuredproviding tremendous insight into the drug-target interaction.

According to Ndieyira, the cantilever technology confronts a growing problem of multidrug-resistant hospital superbugs. It could aid in the drug discovery process by preventing lead-drug candidates from being disregarded due to a lack of equipment with sufficient sensitivity, and its hope is to jumpstart an already stagnated drug-pipeline by providing this sensitivity in an efficient mannerthe cantilever method can simultaneously measure and track a variety of drug-bacteria interactions in real time.

"The cantilever assays provide a resolution that simply cannot be obtained with conventional methods, such as those using fluorescence," said Ndieyira, "For example, cantilever sensors can resolve forces of ~10 pN, which is sensitive enough to detect the rupturing of individual hydrogen bonds." According to the article, a single hydrogen molecule can be the difference between dru
'/>"/>

Contact: Rachel Greene
rachel.greene@jove.com
617-250-8451
The Journal of Visualized Experiments
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Architecture of rod sensory cilium disrupted by mutation
2. Scientists discover a new sensory organ in the chin of baleen whales
3. A whale of a discovery: New sensory organ found in rorqual whales
4. South African living stone plant adapts to extreme conditions in new ways
5. UdeMs IRIC and IRICoR achieve important milestone in their collaboration with Bristol-Myers Squibb
6. DO-HEALTH a multi-center clinical trial on healthy ageing achieves first milestone
7. Drug resistance-associated genes: A cornerstone for the control and protection against tuberculosis
8. Declining fortunes of Yellowstones migratory elk
9. Protected areas provide African birds with stepping stones to survival
10. Microbial diversity course designated as a Milestones in Microbiology site
11. Natural keystone molecules punch over their weight in ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cantilever sensory array: The Rosetta Stone for antibiotic resistance?
(Date:8/28/2014)... is pleased to announce the selection of Dr. Fred ... Membership acknowledges those who have served ESA for at ... of the Society that has reached an extraordinary level. ... Governing Board and then voted on by the ESA ... Ceremony at Entomology 2014, ESA,s Annual Meeting in Portland, ...
(Date:8/28/2014)... news release is available in German . ... water fish, owes its name to a striking pattern of ... types, black cells, reflective silvery cells, and yellow cells emerge ... and arrange as a multilayered mosaic to compose the characteristic ... three cell types have to interact to form proper stripes, ...
(Date:8/28/2014)... his collaborators have developed an online analytic tool that ... cells for biomedical investigation. CellNet is a free-use Internet ... cell engineering. Details of CellNet and its application to ... in the journal Cell . , "This free ... types of cell-based investigations and can potentially offer help ...
Breaking Biology News(10 mins):Fred Baxendale selected as Honorary Member of the Entomological Society of America 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3New tool aids stem cell engineering for medical research 2
... Evolution Group participated in an international research that has resulted ... fly species. The study also includes new data on the ... sixty million years. The research, published in Nature, was ... over the world and consisted in the analysis of the ...
... Inc. and the Prostate Cancer Foundation today announced they ... Program (for Special Team Amplification of Research), an innovative ... heat in cancer therapy to treat prostate cancer, as ... is being launched for the first phase of research ...
... (November 15, 2007) -- In response to the need ... populations of the threatened staghorn coral, Diego Lirman, Ph.D., ... Rosenstiel School of Marine and Atmospheric Science (RSMAS) have ... of staghorn corals. The goals of the coral ...
Cached Biology News:Genome comparison of 12 fruit fly species 2Safeway Inc. and PCF to fund landmark prostate cancer research collaboration 2Safeway Inc. and PCF to fund landmark prostate cancer research collaboration 3Safeway Inc. and PCF to fund landmark prostate cancer research collaboration 4New south Florida nursery to focus on staghorn corals 2
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company ... sanitizer, asks food processors and food handling professionals to ... they’re currently using to Best Sanitizers’ Alpet® E3 ... to fighting cross-contamination and the spread of pathogens in ... are key criteria that make a hand sanitizer most ...
(Date:8/28/2014)... are important devices in spintronics, an electronic which ... electrons but also on their spin and the ... electric into magnetic signals and vice versa. Recently, ... the Institute of Physics at Johannes Gutenberg University ... Prague, and Japan, has for the first time ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
Breaking Biology Technology:Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3A new, tunable device for spintronics 2A new, tunable device for spintronics 3BBK Worldwide Leads Sessions at Key September Events 2
... hot in CEO suites throughout the corporate world. Thanks to ... and World Cons (a.k.a. Enron and Worldcom) of the world, ... their financial reporting and operating processes than ever before. Sarbanes-Oxley ... the head of a cavalcade of legal and regulatory requirements ...
... to Rick Landman the other day. He spotted a quote ... in New York and I asked him about the state ... networker and search professional. He said: "Things are excellent. The ... now in key jobs that affect the bottom line, which ...
... cover a human thumbnail, but they can hold over a ... this emerging technology offers a view of so many tiny ... among the 30,000 genes of the human genome, which are ... with many tiny dots of sample material on them, give ...
Cached Biology Technology:Financial transparency is good; performance transparency is better 2Financial transparency is good; performance transparency is better 3Financial transparency is good; performance transparency is better 4Does your work add to the bottom line - and how do you know? 2Does your work add to the bottom line - and how do you know? 3Does your work add to the bottom line - and how do you know? 4Does your work add to the bottom line - and how do you know? 5Madison biochip research offers geneticists a big view through a small window 2Madison biochip research offers geneticists a big view through a small window 3
...
... 3T3 cells were cultured in DMEM with 4 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
... GC content or with significant secondary structure ... when subjected to PCR result in little ... can be increased by the addition of ... is an effective PCR enhancer for GC-rich ...
Biology Products: