Navigation Links
Canine compulsive disorder gene identified
Date:1/7/2010

. This association of CCD with the CDH2 gene region on chromosome 7 is the first genetic locus identified for any animal compulsive disorder. The neural cadherin-2 gene, CDH2, is an especially attractive candidate disease gene as it is involved in mediating presynaptic to postsynaptic neuronal junction adhesion, neuronal axon outgrowth and guidance in the central nervous system during development when critical brain nerve networks are established. Discovery of this locus raises the intriguing possibility that CDH2, and other neuronal adhesion proteins, are involved in human compulsive behaviors, including those observed in autism spectrum disorder.

"The CDH2 gene is expressed in the hippocampus, a brain region suspected to be involved in OCD," said Dodman, the study's lead author. "Additionally, this gene oversees structures and processes that are possibly instrumental in propagating compulsive behaviors for example, the formation and proper functioning of glutamate receptors." Dodman added that "this finding is congruent with current evidence that N-methyl-D-aspartate (NMDA) blockers are effective in the treatment of OCD."

"The occurrence of repetitive behaviors and similarities in response to drug treatments in both canine CCD and human OCD suggest that common pathways are involved," said Ginns. "We are hopeful that these finding will lead to a better understanding of the biology of compulsive disorder and facilitate development of genetic tests, enabling earlier interventions and even treatment or prevention of compulsive disorders in at-risk canines and humans."


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2

Related biology news :

1. Canine compulsive disorder gene identified in dogs
2. NC State researchers find soy may aid in treating canine cancers
3. Iowa State researcher develops new treatment method for canine eye diseases
4. NC State first university in nation to offer canine bone marrow transplants
5. Computer savvy canines
6. Brain pattern associated with genetic risk of obsessive compulsive disorder
7. Uniform method to interpret autism spectrum disorders is defined at Ben-Gurion University
8. Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
9. Depression and anxiety disorders of adolescents are not the same thing
10. Are the monoamines involved in shaping conduct disorders?
11. Fighting the burden of mental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... FindBiometrics, the leading source of biometrics industry news, interviews and ... "When we launched FindBiometrics 12 years ago the ... founder and CEO of FindBiometrics. "Now it,s maturing very quickly. ... players on a very broad scale.  We are known for ...
(Date:1/22/2015)... Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and ... reports on the recent success of the Wocket™ smart wallet at CES ... smart wallet was named as one of the "11 Hot Products at ... Products Launched At CES So Far" by Newseveryday.com and "The top 10 ...
(Date:1/22/2015)... Inc. , a market leader of iris-based identity authentication solutions, ... the new role of Senior Vice President of Mobile and ... platforms and wearable solutions for EyeLock,s technologies. Gerber brings more ... industry to his role at EyeLock, with expertise in human ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... the John Innes Centre in Norwich have discovered how roots ... discovery, described in the forthcoming edition of Science, also explains ... as they burrow. The key is in the fuzzy ... Liam Dolan. We have identified a growth control mechanism that ...
... with respect to the mystery of handedness in biomolecules. Researchers ... University, found that some of the possible abiotic precursors to ... carry handedness in a larger number than previously thought. , ... of the Proceedings of the National Academy of Sciences (PNAS). ...
... 28, 2008 Utilizing a technique that combines low ... scientists and others have revealed for the first time ... The knowledge of the electronic properties of DNA is ... to nanotechnology -- for example in the study of ...
Cached Biology News:ASU researcher may have discovered key to life before its origin on Earth 2Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers 2
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... software package designed to minimize the potential risks of ... now available to the gene synthesis industry and synthetic ... has licensed GenoTHREAT, a software tool that helps detect ... as an open-source project by a team led by ...
... chemical detectors that require an external power source, ... relies on semiconductor nanowires, rather than traditional batteries. ... traditional sensors and is simple, highly sensitive and ... be the first step in making an easily ...
... a microscope by removing the lens to create a system ... a hand but powerful enough to create three-dimensional tomographic images ... week in the early online edition of the journal ... first demonstration of lens-free optical tomographic imaging on a chip, ...
Cached Biology Technology:Open-source software designed to minimize synthetic biology risks 2Livermore researchers develop battery-less chemical detector 2Optical microscope without lenses produces high-resolution 3-D images on a chip 2Optical microscope without lenses produces high-resolution 3-D images on a chip 3
... CE 4100 high pressure dual piston pump and ... for added flexibility. The system is ... unit, CE 4901., The CE 4901 PowerStream software ... with Windows 98 and 2000, offers the same ...
Anti 4-hydroxy-2-hexenal (4-HHE) Monoclonal Antibody (HNEJ-2)...
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
... The new Vivaspin 2 bridges the gap ... centrifugal concentrators. This device combines the speed ... internal surface and membrane area for superior ... with a choice of PES, Cellulose Triacetate ...
Biology Products: