Navigation Links
Canine compulsive disorder gene identified
Date:1/7/2010

WORCESTER, Mass. A collaboration between the University of Massachusetts Medical School, the Cummings School of Veterinary Medicine at Tufts University and the Broad Institute at the Massachusetts Institute of Technology has identified a genetic locus on canine chromosome 7 which coincides with an increased risk of obsessive compulsive disorder (OCD) susceptibility. The findings, published in the January 2010 edition of Molecular Psychiatry, suggest that particular genetic proteins may possibly influence central nervous system development and increase the risk of OCD.

Characterized by time-consuming, repetitive behaviors, OCD affects roughly 2 percent of humans. Meanwhile, the equally distressing canine equivalent, canine compulsive disorder (CCD), is more prevalent in certain dog breeds, especially Dobermans and Bull Terriers.

For more than a decade, animal behaviorists Nicholas Dodman, BVMS, MRCVS, professor of clinical sciences, and Alice Moon-Fanelli, PhD, clinical assistant professor, at the Cummings School of Veterinary Medicine at Tufts, collected blood samples from carefully characterized Doberman patients exhibiting flank- and/or blanket-sucking compulsive behaviors, as well as healthy, unaffected Dobermans. In 2001, Edward Ginns, MD, PhD, director of the Program in Medical Genetics at UMass Medical School, joined the effort, enabling genetic studies that culminated in the genome wide association study that began in 2007 using the canine Affymetrix genotyping array at the Broad Institute.

The chromosome 7 location most significantly associated with CCD is located within the neural cadherin-2 gene, CDH2. CDH2 is widely expressed, mediating synaptic activity-calcium flux related neuronal adhesion. Dogs showing multiple compulsive behaviors had a higher frequency of the "risk" associated DNA sequence than dogs with a less severe phenotype (60 and 43 percent, respectively, compared with 22 percent in unaffected dogs). This association of CCD with the CDH2 gene region on chromosome 7 is the first genetic locus identified for any animal compulsive disorder. The neural cadherin-2 gene, CDH2, is an especially attractive candidate disease gene as it is involved in mediating presynaptic to postsynaptic neuronal junction adhesion, neuronal axon outgrowth and guidance in the central nervous system during development when critical brain nerve networks are established. Discovery of this locus raises the intriguing possibility that CDH2, and other neuronal adhesion proteins, are involved in human compulsive behaviors, including those observed in autism spectrum disorder.

"The CDH2 gene is expressed in the hippocampus, a brain region suspected to be involved in OCD," said Dodman, the study's lead author. "Additionally, this gene oversees structures and processes that are possibly instrumental in propagating compulsive behaviors for example, the formation and proper functioning of glutamate receptors." Dodman added that "this finding is congruent with current evidence that N-methyl-D-aspartate (NMDA) blockers are effective in the treatment of OCD."

"The occurrence of repetitive behaviors and similarities in response to drug treatments in both canine CCD and human OCD suggest that common pathways are involved," said Ginns. "We are hopeful that these finding will lead to a better understanding of the biology of compulsive disorder and facilitate development of genetic tests, enabling earlier interventions and even treatment or prevention of compulsive disorders in at-risk canines and humans."


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Related biology news :

1. Canine compulsive disorder gene identified in dogs
2. NC State researchers find soy may aid in treating canine cancers
3. Iowa State researcher develops new treatment method for canine eye diseases
4. NC State first university in nation to offer canine bone marrow transplants
5. Computer savvy canines
6. Brain pattern associated with genetic risk of obsessive compulsive disorder
7. Uniform method to interpret autism spectrum disorders is defined at Ben-Gurion University
8. Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
9. Depression and anxiety disorders of adolescents are not the same thing
10. Are the monoamines involved in shaping conduct disorders?
11. Fighting the burden of mental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... HONG KONG , March 30, 2017 ... developed a system for three-dimensional (3D) fingerprint identification by adopting ground ... technology into a new realm of speed and accuracy for use ... applications at an affordable cost. ... ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health ... and Management Systems Society (HIMSS) Analytics for achieving ... Adoption Model sm . In addition, CHS previously ... U.S. hospitals using an electronic medical record (EMR). ... its high level of EMR usage in an ...
(Date:3/23/2017)... Mar. 23, 2017 Research and Markets has ... Analysis & Trends - Industry Forecast to 2025" report to ... ... a CAGR of around 8.8% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... July 20, 2017   KCNQ2 Cure Alliance ... evaluations company, today announced that they have completed ... genetic mutation implicated in KCNQ2 epileptic encephalopathy. They ... a second case involving an additional KCNQ2 genetic ... Alliance and Pairnomix entered into a collaboration to ...
(Date:7/20/2017)... , ... July 20, 2017 , ... ... to make clinical trial sites and study participants truly unified. TrialKit, a native ... (FDA 21 CFR Part 11) research studies entirely on mobile devices. With TrialKit, ...
(Date:7/18/2017)... ... July 18, 2017 , ... Sourcing custom glass or quartz parts can be ... capabilities to properly execute your job can take many hours of emails, phone calls ... portal designed to showcase the company’s capabilities and core custom categories, and enables you ...
(Date:7/18/2017)... ... , ... G-CON today announced that it has received Notices ... Applications 14/858,857 and 13/669,785 both entitled Modular, Self-Contained, Mobile Clean Room. The U.S. ... of G-CON’s R&D investments and validate the G-CON platform as a novel way ...
Breaking Biology Technology: