Navigation Links
Cancerous tumors deliver pro-metastatic information in secreted vesicles
Date:5/29/2012

tential.

The researchers were interested to see if the exosomes budding off of melanoma actually participated in the course of the cancer -- and they found that they do, and to a great extent.

"Upon their release from the primary tumor, exosomes derived from melanoma cells fuse with cells in distant metastatic organs and lymph nodes, mediating vascular leakiness and inflammation, thereby promoting the formation of pre-metastatic niches that enhance future metastatic growth," Dr. Lyden says.

According to Dr. Peinado, a number of exosomal proteins are transferred by the exosomes to BMDCs where they can reprogram or "educate" the cells to participate in the metastatic cascade. "We found an oncogenic protein, called MET, that is produced by highly metastatic tumors and packaged into pro-metastatic exosomes. The tumor exosomes circulate, fuse and transfer their information, including the MET oncoprotein, to many cells, such as bone marrow cells, which in turn promote a pro-metastatic phenotype," he says.

They also discovered that the education of BMDCs by exosomes is long-lasting, and this may explain how a tumor dormant for decades suddenly develops metastatic disease. These findings are crucial, says Dr. Bromberg, because "educated bone marrow is the key in disease recurrence and may even foster a future secondary cancer."

Examining human blood samples, the scientists found a distinct signature of exosomal proteins (including MET) in patients with stage IV, widely metastatic melanoma that was not found in blood exosomes from patients with non-metastatic melanoma.

They say this protein signature could be used to predict which patients with stage III disease and local lymph node metastasis would then go on to develop distant metastatic disease. "Treatment modalities could be initiated earlier in these high-risk patients to prevent disease progression," Dr. Lyden says. "Our results demonstrated that MET oncoprotein
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Light can detect pre-cancerous colon cells
2. Strawberries may slow precancerous growth in esophagus
3. Estrogen may help precancerous cells spread in oral cavity
4. Scripps Research scientists find new way to attack cancerous cells
5. Zebrafish provide a model for cancerous melanoma in humans
6. A single stem cell mutation triggers fibroid tumors
7. TGen leads new National Institutes of Health study of brain tumors
8. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
9. Team finds new way to image brain tumors and predict recurrence
10. MU researchers photoacoustic device finds cancer cells before they become tumors
11. University Hospitals Seidman Cancer Center tests novel drug that makes brain tumors glow hot pink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... . X-ray ... of X-rays through a specimen instead of attenuation resulting ... often of much higher quality than those based on ... Pfeiffer are particularly interested in developing new approaches for ... imaging. One main goal is to make this method ...
(Date:7/11/2014)... 2014, Shenzhen, China Researchers from Salk Institute for ... first time evaluated the safety and reliability of ... developed a new method, TALEN-HDAdV, which could significantly ... cell (hiPSC). This study published online in ... foundation for stem cell-based gene therapy. , The ...
(Date:7/11/2014)... 11, 2014 Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... Cold Spring Harbor, NY Every gardener knows the look ... earthy smell, and the sweet juicy flavor are hard to ... from the backyard garden variety, which can grow endlessly under ... will be canned for sauces and juice are harvested from ...
... Various medications have been developed to treat neurodegenerative ... gaining widespread interest such disorders. Brain Research Institute ... Crneci, found that the protein p300, which is ... during specific learning tasks, is at the same ...
... the Boston area, Mexico, and Norway have completed a ... populations. The study identified recurrent genetic mutations not previously ... which targeted treatments have been approved for other forms ... role human papillomavirus (HPV) plays in the development of ...
Cached Biology News:Genetic discovery points the way to much bigger yields in tomato, other flowering food plants 2International team completes systematic, genomic study of cervical cancer 2International team completes systematic, genomic study of cervical cancer 3International team completes systematic, genomic study of cervical cancer 4International team completes systematic, genomic study of cervical cancer 5
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its new ... GLOBAL MARKETS , the global market for digital polymerase ... 2013. This is estimated to grow to $490 billion ... (CAGR) of 28.6%. , New digital PCR technology has ... the broader PCR field. The opportunities presented by this ...
(Date:7/11/2014)... AZ (PRWEB) July 11, 2014 ... device company specializing in the soft tissue reconstruction ... All-Suture Anchor System for surgeries involving the shoulder ... fixation through a novel, inserter-controlled deployment method. The ... to partial deployment, anchor pull-out, or anchor displacement ...
(Date:7/10/2014)... Understanding the need for better quality and higher ... that currently exists in this area, ChanTest has recently ... validated ion channel and GPCR cell lines. ChanTest’s ... channels control many critical physiological functions throughout the body. ... to treat a variety of human diseases. , ...
(Date:7/10/2014)... Angeles, CA (PRWEB) July 10, 2014 ... and Bioanalytical techniques during 18-20 August, 2014 at Double ... critically review the recent developments in Analytical & Bioanalytical ... the globe. , Speaking on this occasion, Dr. Srinubabu ... Analytica Acta conference is a remarkable one in ...
Breaking Biology Technology:Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4
... Access to ZFN Technology To Potentially Improve ... ... SGMO ) today announced that it has entered into a,second ... to include additional targets for potential improvement,of production cell lines using ...
... and Marburg viruses using virus-like particles (VLPs) ... Researchers from the U.S. Army Medical Research Institute ... (Feb. 26) at the 2008 ASM Biodefense and ... VLPs are one of the most promising candidates ...
... revenue growth ... 2007 Highlights: * Product revenues ... pulse oximeter units increase 20% to 116,300 units, IRVINE, Calif., Feb. 26 ... & Low Perfusion pulse oximetry, today announced its financial,results for both the quarter ...
Cached Biology Technology:Sangamo BioSciences Announces Expansion of Research and License Agreement With Genentech for ZFP Technology for Protein Pharmaceutical Production 2Sangamo BioSciences Announces Expansion of Research and License Agreement With Genentech for ZFP Technology for Protein Pharmaceutical Production 3Combination vaccine protects monkeys from ebola and Marburg viruses 2Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 2Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 3Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 4Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 5Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 6Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 7Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 8Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 9Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 10Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 11Masimo Reports Fourth Quarter 2007 and Full Year 2007 Financial Results 12
... The new Adept CE 4100 high ... superb flow precision, with software drive compensation, ... from 0.001-10mL/min are selectable in 0.001mL steps. ... are inert and bio-compatible., Pumps may be ...
... angle system, 220-240 V, is used to resolve ... fragments by pulsed field gel electrophoresis (PFGE). The ... pump, 14 x 13 cm casting stand with ... thick comb, screened cap, disposable plug molds, 12 ...
... Immuno-Blot PVDF membrane and filter paper ... PVDF membrane and two sheets of thick ... blotting membrane and filter paper sandwich. These ... high binding capacity immunoblotting fit Ready Gel-sized ...
... fromStreptomyces griseolusthat inhibits protein synthesis. Acts ... eukaryote ribosomes. Reported to induce apoptosis ... promyelocytic leukemia cells, Jurkat cells, ventricular ... intracellular signals and immediate early gene ...
Biology Products: