Navigation Links
Cancer vaccines self-sabotage, channel immune attack to injection site
Date:3/3/2013

cells in the mouse model to see where they went.

  • Mice without IFA had the bulk of T cells light up in their tumors with minimal presence at the vaccination site.
  • T cells built up at the injection site in mice that received IFA-based vaccine, with a tiny showing in the tumor.

Response duration was tested in gp100/IFA and control IFA vaccines. The antigen/IFA combination gathered and persisted at the vaccination site, where it could still stimulate the proliferation of injected T cells 96 days after vaccination.

A separate set of experiments showed the antigen/IFA-driven T cells were forced to kill themselves at the vaccination site by a variety of cell suicide-inducing proteins.

Reducing vaccine depots at injection site

Overwijk and colleagues inferred that a possible answer to the problem was to reduce the size and persistence of vaccine "depots" at the injection site.

They tested a vaccine based on a saline solution instead of IFA and found that antigens cleared more quickly but did not spark the desired T cell response. A combination of three stimulatory molecules (covax) was added to the saline/peptide vaccine, producing a strong T cell response. IFA/peptide vaccine produced a strong T cell response but also stronger post-peak T cell suicide.

A comparison of saline/peptide/covax vs. IFA/peptide/covax showed the saline version caused T cells to home to the tumor and destroy them, while the IFA version focused T cells at the vaccination site, killing normal tissue and inducing chemokines that damaged and killed T cells.

"IFA-based vaccination sites essentially outcompete tumor sites for T cell recognition and accumulation, chemokine production and tissue damage," Overwijk said. "It's an engineering flaw in those vaccines that we didn't appreciate until now. Fortunately, our results also directly instruct us how to design new, more powerful vaccine formulas for tr
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Embryonic development protein active in cancer growth
3. BRG1 mutations confer resistance to hormones in lung cancer
4. Genetic variation in East Asians found to explain resistance to cancer drugs
5. Beyond the microscope: Identifying specific cancers using molecular analysis
6. Marshall University study may lead to new treatments for prostate cancer
7. Salk scientists open new window into how cancers override cellular growth controls
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Genetic abnormality offers diagnostic hope for childrens cancer
10. Protein jailbreak helps breast cancer cells live
11. Breast cancer risk gene discovery fast tracked by new technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... 22, 2015 According to a ... (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, Databases), by ... Utilities, Consumer and Home) - Global Forecast to 2020", ... $2.77 Billion in 2015 to $6.19 Billion by 2020, ... 79 market data Tables and   43 Figures spread ...
(Date:5/20/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... subsidiary, 3D-ID LLC, a company engaged in biometric identification ... biometrics technology portion of the recently awarded TIES (Technical ... of the Army. 3D-ID LLC has a ... law enforcement and security agencies. Gino ...
(Date:5/18/2015)... Fingerprint Cards (FPC) has received an ... and FPC1035 from one if its module partners. Deliveries are ... 2015 and the sensors will be used by smartphone manufacturers ... 2015 hereby amount to 740 MSEK to date. In addition ... and a number of smaller orders not separately communicated amounting ...
Breaking Biology News(10 mins):Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... for their future needs just as we humans can ... and Helena Osvath,s research, from Lunds University Cognitive Science ... of advanced planning capacities in non-human species. Their findings ... Animal Cognition . The complex skill of future ...
... The world,s only known hairy-nosed otter in captivity, one of the ... and a Buddhist blessing today. ... killed by a fisherman, was released into a large new enclosure ... located near Phnom Penh. The release was celebrated with a ...
... be the early targets of new trans-Pacific research using ... of Queensland (UQ) and the University of Washington (UW) ... Anna Bligh announced $650,000 from the National and International ... of the pathogens of two debilitating mosquito-borne diseases, malaria ...
Cached Biology News:Great apes think ahead 2World's only captive hairy-nosed otter gets new home 2World's only captive hairy-nosed otter gets new home 3
(Date:6/2/2015)... June 2, 2015 TapImmune, Inc. (OTCQB: TPIV), ... investors have reached an agreement whereby the institutional investors ... warrants to provide the Company up to $4.93M in ... S-1 registration statement. Under the restructured terms and subject ... additional warrants which could result in a larger influx ...
(Date:6/2/2015)... 2015 Global Stem Cells Group ... Bioquark, Inc.’s biologic products for the regeneration and repair of ... Global Stem Cells Group’s ambitious expansion plans in Latin America, ... access to regenerative medicine and stem cell therapies. , ... biologics that have the ability to alter the regulatory state ...
(Date:6/2/2015)... , June 02, 2015 Research and ... "Molecular Diagnostics - Global Market Size, Strategy and ... offering. "Molecular Diagnostics - Global Market Size, ... that analysts and planners can use. Hundreds of pages ... United States Medicare Fee Payment Schedules to help understand ...
(Date:6/2/2015)... DUBLIN , June 02, 2015 Research ... the "Genotyping Market by Technology, Application & by ... their offering. The global genotyping market is ... Billion in 2015, at a CAGR of 22.3% during ... Market growth will be attributed to the availability of ...
Breaking Biology Technology:TapImmune Announces Agreement To Facilitate Near Term Capital Infusion; Expediting Path Toward Phase II Trial Initiation 2TapImmune Announces Agreement To Facilitate Near Term Capital Infusion; Expediting Path Toward Phase II Trial Initiation 3Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 2Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 3Global Molecular Diagnostics Report 2015-2019 - Market Size, Strategy and Forecasts 2Global Molecular Diagnostics Report 2015-2019 - Market Size, Strategy and Forecasts 3Genotyping Market Report 2015 by Technology, Application & by Products - Global Forecast to 2020 for the $17 Billion Market 2
... Bill of Rights are right about one thing: Wisconsin needs ... and local government. Our tax system hampers economic growth and ... ,But the opponents of TABOR are right about one thing, ... put at risk our economic growth and threaten our quality ...
... with the product managers at Palm and got a peek at ... be an entry-level digital organizer for the masses of people who ... simple product that delivered real value. After listening to the briefing ... close to the product marketing manager and said, "You're going to ...
... MobilePro Corp. announced today the company has ... , a Janesville-based Internet services provider. The deal is ... in annualized revenue and to be accretive to MobilePros ... of definitive agreements and customary closing conditions, is expected ...
Cached Biology Technology:Tax consumption over production to reform Wisconsins tax system 2Tax consumption over production to reform Wisconsins tax system 3The Palm to "de-Zire" 2The Palm to "de-Zire" 3
... provides complete components including positive and ... of DNA fragmentation in cultured cells ... BrdU in the procedure provides greater ... Results can be analyzed by fluorescence ...
The LAS-3000 imaging system combines new CCD camera technology with a simplified user interface to provide significantly improved system sensitivity with a wide range of modularities. This system is...
This kit is designed to select cells labeled with biotinylated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
This pump accomodates StemSep ; pump feed columns of the following sizes : 0.3in., 0.5in., 0.6in., and 1.0in.....
Biology Products: