Navigation Links
Cancer therapy may be too targeted
Date:3/16/2014

Researchers have identified two novel cancer genes that are associated with the development of a rare, highly aggressive, cancer of blood vessels. These genes may now act as markers for future treatments and explain why narrowly targeted therapies that are directed at just one target fail.

Angiosarcoma is a rare cancer of blood vessels. It occurs either spontaneously or can appear after radiotherapy treatment. Although quite rare, with approximately 100 people diagnosed with the cancer in the UK each year, the survival outcomes for the cancer are poorer than many other cancer types.

Scientists have previously developed drugs against angiosarcoma that target specific cellular pathways involved in the formation of blood vessels. However, these drugs have had little or no success.

In this study, the team found that 40 per cent of angiosarcomas carry mutations in genes that control blood vessel growth, including two novel cancer genes, PTPRB and PLCG1.

"Because this cancer doesn't respond well to traditional chemotherapy and radiotherapy, it makes sense to develop drugs that target pathways that control blood vessel formation," says Dr Peter Campbell, co-lead author from the Wellcome Trust Sanger Institute "We found two novel cancer genes that control blood vessel formation which are mutated in this cancer and which could be targeted for treatment of this highly aggressive cancer."

However, in some patients, the team found multiple mutations in the pathway that controls blood vessel growth. These multiple mutations may make drugs developed for a single target ineffective in some patients. This study emphasises the need to take into account the effects multiple, co-operating mutations can have when designing targeted treatments for patients.

"This indicates that we may need to think more broadly to find a suitable treatment," adds Dr Campbell.

"This study really highlights the power that a limited number of samples can have to influence the clinical and biological understanding of a rare disease, in this case angiosarcoma," says Professor Adrian Harris, co-lead author from the University of Oxford. "Not only does our study change the way people view the biology of this tumour, it acts as a guide for future drug trials in angiosarcoma patients."

Because so few people are affected by angiosarcoma, clinical trials can be very difficult to conduct. With this new information researchers now need to determine if existing drugs could be effective against this detrimental cancer.

"It's extremely important to that we continue to study rare cancers such as angiosarcomas," says Dr Sam Behjati, first author from the Wellcome Trust Sanger Institute. "Not only will this help the many patients with these cancers and improve treatment strategies, but it will help us understand the full landscape of cancer-causing mutations and the underlying biology."


'/>"/>

Contact: Mary Clarke
press.office@sanger.ac.uk
44-012-234-95328
Wellcome Trust Sanger Institute
Source:Eurekalert

Related biology news :

1. A gene family that suppresses prostate cancer
2. CNIO researcher awarded by the Prostate Cancer Foundation
3. Protein key to cell motility has implications for stopping cancer metastasis
4. Breast cancer gene could play critical role in obesity and diabetes
5. Vitamin D increases breast cancer patient survival
6. UT Arlington study links BPA and breast cancer tumor growth
7. New therapies targeting cancer, Alzheimers goal of UH physicist
8. Researchers capture most complete picture of gene expression in cancer cell cycle
9. Applying math to cancer, climate, crime and cameras
10. Cholesterol study suggests new diagnostic, treatment approach for prostate cancer
11. Researchers develop antibody-targeted treatment for recurrent small-cell lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
(Date:11/22/2016)... According to the new market research report "Biometric ... Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), Application, ... is expected to grow from USD 10.74 Billion in 2015 to reach ... and 2022. Continue Reading ... ...
(Date:11/19/2016)... , Nov. 18, 2016 Securus Technologies, ... solutions for public safety, investigation, corrections and monitoring, announced ... smaller competitor, ICSolutions, to have an independent technology judge ... the most modern high tech/sophisticated telephone calling platform, and ... customers that they do most of what we do ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... , ... December 01, 2016 , ... ... long-term client Nanowear on their recent FDA Class II 510(k) clearance for their ... significant hurdle in commercializing remote cardiac monitoring devices that rely on cloth-based nanosensors. ...
(Date:12/2/2016)... a world leader in rapid infectious disease tests, introduced the Company,s newest product, the ... (Photo: http://photos.prnewswire.com/prnh/20161201/444905 ) Continue Reading ... ... , , bioLytical was invited by the ... INSTI HIV Self Test to 350 pharmacy representatives in Nairobi ...
(Date:11/30/2016)... Biotest Pharmaceuticals Corporation (BPC), a leading manufacturer ... addition of its newest plasma collection center located at ... The 15,200 square foot state-of-the-art facility officially opened its ... the total number of BPC,s plasma collection centers to ... Chief Executive Officer said "We are pleased to become ...
(Date:11/30/2016)... November 2016   Merck , ein ... Unterzeichnung einer Reihe von Vereinbarungen mit Evotec ... AG Screeningleistungen für Mercks Palette genetischer Reagenzien ... auf diese Bibliotheken in Kombination mit Evotecs ... Weg zur Ermittlung und Erforschung neuer Arzneimitteltargets.    ...
Breaking Biology Technology: