Navigation Links
Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds
Date:7/18/2011

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have found that a type of normal stem cell fuels ovarian cancer by encouraging cancer stem cells to grow.

Cancer stem cells are the small number of cells in a tumor that drive its growth and spread. Traditional cancer treatments do not kill these cells, which is why cancer treatments often fail.

In a study published online in the Journal of Clinical Investigation, researchers looked in ovarian tissue at the mesenchymal stem cells, which are normal cells found throughout the body. These cells can form different specialized cells such as fat, bone or cartilage.

Mesenchymal stem cells are known to be helpful with wound healing, which has many scientists conjecturing that they may help combat cancer. In this study, the researchers observed that mesenchymal stem cells in ovarian tumors were different than mesenchymal stem cells from healthy ovaries. And in fact, the mesenchymal stem cells in the ovarian tumors were fueling the cancer.

"Cancer is very good at tricking the mesenchymal stem cells into doing what the cancer likes. The cancer takes the cells hostage and uses them to promote the cancer's growth," says study author Ronald Buckanovich, M.D., Ph.D., assistant professor of internal medicine and of obstetrics and gynecology at the U-M Medical School.

The researchers used mouse models and human tissue samples of both normal ovaries and ovarian cancer, to look at what happened to the mesenchymal stem cells. They also noticed the cancer-associated mesenchymal stem cells increased tumor size, primarily by increasing the number of cancer stem cells.

At the same time, the researchers saw that a type of protein called BMP2 was prevalent in the cancer-associated mesenchymal stem cells. BMP2 is a so-called master regulatory protein, and is carefully regulated in normal cell function. The researchers found more than thre
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Trastuzumab and chemotherapy improved survival in HER2-postive breast and brain cancer patients
2. UT Southwestern research reveals that significantly more genetic mutations lead to colon cancer
3. Cancer gene therapy from camels
4. Cancer data not readily available for future research
5. UT faculty improving surgical outcomes for children, cancer patients
6. Study explains why men are at higher risk for stomach cancer
7. Stem cells restore cognitive abilities impaired by brain cancer treatment
8. PSA test for men could get a second life for breast cancer in women
9. Low dose naltrexone (LDN): Harnessing the bodys own chemistry to treat human ovarian cancer
10. GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients
11. AACR hosts Frontiers in Basic Cancer Research Conference in San Francisco
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds 
(Date:12/24/2014)... its launch in December 2014, the 1U™ app ... trying to remember their usernames and passwords through replacing the ... To assist people who have struggled to remember usernames and ... and focuses on redefining identity, announced today that it is ...
(Date:12/22/2014)... Dec. 22, 2014  The 2014 Holiday Season may be ... Market Intelligence reports that the long anticipated floodgates for ... intensifying demand for smart phones, tablets, and wearable mobile ... of 2.5 billion users with nearly 4.8 billion biometric ...
(Date:12/19/2014)... 2014  23andMe, Inc., the leading personal genetics company, today announced ... genetic ancestry of individuals from across the United ... than four hundred years ago, the United States ... from different continents. This study illuminates how American history and ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Contributions to the systematics of New World macro-,moths " series ... important role in publishing taxonomic changes and new discoveries concerning ... publications by 38 authors, this well-established series is among the ... coverage in Zookeys has previously focused primarily on ...
... have designed a set of biomarkers that can be used ... West Nile virus, two infectious diseases transmitted by the bite ... these viral diseases, which affect millions of people worldwide. ... company composed of professionals from the private sector and from ...
... be reprogrammed to pluripotency and thus regain the ability ... these so-called induced pluripotent stem cells (iPS cells) represent ... biochemical processes that underlie reprogramming are still not understood. ... Planck Institute for Molecular Biomedicine in Mnster, Germany now ...
Cached Biology News:ZooKeys opens the gates to America's moth diversity 2Learning from the linker 2
(Date:1/22/2015)... Jan. 22. 2015  Varian Medical Systems (NYSE: VAR ... honored for its commitment to sustainability with inclusion on a ... the highest ranked healthcare equipment company among the Corporate Knights ... World Economic Forum at Davos, Switzerland . ...
(Date:1/22/2015)... N.J. , Jan. 22, 2015  Derma Sciences, ... regeneration company focused on advanced wound care, announces ... placental tissues, have been added to the Premier, ... increases the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... (NYSE: MDT ) has submitted a pre-market ... (FDA) for the use of Medtronic,s SynchroMed ® ... catheter) for use with United Therapeutics, Remodulin ® ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
Breaking Biology Technology:Varian Honored Among World's 100 Most Sustainable Corporations 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... and memory functions of future electronic devices could shrink dramatically ... instead of the many tens of nanometers that characterize today,s ... to control domain walls, the ultrathin transition zones that separate ... properties. , In a material called bismuth ferrite, ...
... Sciences award in this inaugural edition of the BBVA ... physicists Peter Zoller (Austria, 1952) and Ignacio Cirac (Manresa, ... in the words of the jury chaired by Theodor ... research is opening up vital new avenues for the ...
... Cardica, Inc.,(Nasdaq: CRDC ) today reported financial ... and six months ended December 31, 2008. , ... Anastomosis System by,cardiothoracic surgeons for use in coronary artery ... been encouraging," said,Bernard A. Hausen, M.D., Ph.D., president and ...
Cached Biology Technology:Domain walls that conduct electricity 2Domain walls that conduct electricity 3Domain walls that conduct electricity 4Domain walls that conduct electricity 5Peter Zoller and Ignacio Cirac, awarded by the BBVA Foundation 2Cardica Announces Fiscal 2009 Second Quarter Financial Results 2Cardica Announces Fiscal 2009 Second Quarter Financial Results 3Cardica Announces Fiscal 2009 Second Quarter Financial Results 4Cardica Announces Fiscal 2009 Second Quarter Financial Results 5Cardica Announces Fiscal 2009 Second Quarter Financial Results 6Cardica Announces Fiscal 2009 Second Quarter Financial Results 7
Recombinant Human PTP1B (aa 2-321), CF...
Rat CXCL7/Thymus Chemokine-1 DuoSet Economy Pack, 45 Plate...
X-Gal, 1 g. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzymes...
Recombinant Rat Fas Ligand/TNFSF6...
Biology Products: