Navigation Links
Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds
Date:7/18/2011

ANN ARBOR, Mich. Researchers at the University of Michigan Comprehensive Cancer Center have found that a type of normal stem cell fuels ovarian cancer by encouraging cancer stem cells to grow.

Cancer stem cells are the small number of cells in a tumor that drive its growth and spread. Traditional cancer treatments do not kill these cells, which is why cancer treatments often fail.

In a study published online in the Journal of Clinical Investigation, researchers looked in ovarian tissue at the mesenchymal stem cells, which are normal cells found throughout the body. These cells can form different specialized cells such as fat, bone or cartilage.

Mesenchymal stem cells are known to be helpful with wound healing, which has many scientists conjecturing that they may help combat cancer. In this study, the researchers observed that mesenchymal stem cells in ovarian tumors were different than mesenchymal stem cells from healthy ovaries. And in fact, the mesenchymal stem cells in the ovarian tumors were fueling the cancer.

"Cancer is very good at tricking the mesenchymal stem cells into doing what the cancer likes. The cancer takes the cells hostage and uses them to promote the cancer's growth," says study author Ronald Buckanovich, M.D., Ph.D., assistant professor of internal medicine and of obstetrics and gynecology at the U-M Medical School.

The researchers used mouse models and human tissue samples of both normal ovaries and ovarian cancer, to look at what happened to the mesenchymal stem cells. They also noticed the cancer-associated mesenchymal stem cells increased tumor size, primarily by increasing the number of cancer stem cells.

At the same time, the researchers saw that a type of protein called BMP2 was prevalent in the cancer-associated mesenchymal stem cells. BMP2 is a so-called master regulatory protein, and is carefully regulated in normal cell function. The researchers found more than thre
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Trastuzumab and chemotherapy improved survival in HER2-postive breast and brain cancer patients
2. UT Southwestern research reveals that significantly more genetic mutations lead to colon cancer
3. Cancer gene therapy from camels
4. Cancer data not readily available for future research
5. UT faculty improving surgical outcomes for children, cancer patients
6. Study explains why men are at higher risk for stomach cancer
7. Stem cells restore cognitive abilities impaired by brain cancer treatment
8. PSA test for men could get a second life for breast cancer in women
9. Low dose naltrexone (LDN): Harnessing the bodys own chemistry to treat human ovarian cancer
10. GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients
11. AACR hosts Frontiers in Basic Cancer Research Conference in San Francisco
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer stem cells recruit normal stem cells to fuel ovarian cancer, U-M study finds 
(Date:7/11/2014)... "mouse TRAP" to capture the early signs of kidney ... the Journal of Clinical Investigation . Their new ... extract cellular and genetic information from a variety of ... Institute for Medical Research in 2008, TRAP involves attaching ... of the cell type of interest. Scientists can then ...
(Date:7/11/2014)... from the Max Planck Institute for Medical Research in ... understanding photosynthesis, the process by which the Earth first ... and which is therefore crucial for all higher forms ... the first direct visualization of a crucial event in ... specific protein complex, photosystem II, splits water into hydrogen ...
(Date:7/11/2014)... division of the striatum is also involved in ... of substance P in the striatal marginal division ... his team, College of Biophotonics, South China Normal ... P receptor, neurokinin 1 was highly expressed in ... rats. Unilateral or bilateral injection of an antisense ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... disease that can lead to life-threatening heart and digestive ... thought, according to research from The University of Texas ... years now, and this year the number of disease-causing ... integrative biology and philosophy at The University of Texas ...
... the most stressful thing that can happen to anybody. But ... of traumatic experiences. Most humans come to terms with it ... How weaning takes place, however, can have a dramatic effect on ... this is so, at least for horses, comes from the latest ...
... Over the next decade, the population of cancer survivors over ... "We can expect a dramatic increase in the ... a history of cancer," said Julia Rowland, Ph.D., director of ... Control and Population Sciences at the National Cancer Institute (NCI). ...
Cached Biology News:Chagas disease may be a threat in South Texas, says researcher 2The short goodbye: Weaning foals 2The short goodbye: Weaning foals 3Older cancer survivor population to increase substantially 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 OMICS Group’s ... techniques during 18-20 August, 2014 at Double Tree by ... the recent developments in Analytical & Bioanalytical research methods ... , Speaking on this occasion, Dr. Srinubabu Gedela, MD ... Acta conference is a remarkable one in bringing a ...
(Date:7/10/2014)... Capital, a firm specializing in acquiring and managing food ... the Slim-Fast brand from Unilever. Unilever will retain a ... were not disclosed. Slim-Fast is a branded ... shakes, powders, bars and snacks to retail customers throughout ... United Kingdom and Ireland.  The ...
(Date:7/10/2014)... the fight against terrorism with the creation of a ... the use of light and special glass fibres. , ... Chemical , the researchers describe a novel optical fibre ... as 6.3 ppm (parts per million). It requires an ... explosives detection has involved looking for metals that encase ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... few as 1 cell , Karen Dolter ... RNA microprep kit provides a,convenient method for isolating total ... is bound to a solid support, which eliminates the,need ... high quality, with no detectable DNA contamination and is ...
... higher transformation efficiency of ligated DNA , ... ,Stratagene Cloning Systems, Inc. , Stratagenes new, high-efficiency ... efficiency of ligated DNA. Epicurian,Coli ... for ligated DNA that were up to 25-fold ...
... Mycoplasma PCR Primer Set for fast and easy ... Arrington ,Yale University , D. R. Staggs ,Genetic Applications ... mammalian cell cultures can substantially,reduce the potency of transfection ... before the optimal amounts of LipoTAXI ...
Cached Biology Technology:Fast Isolation of Total RNA from Small Numbers of Cells 2Fast Isolation of Total RNA from Small Numbers of Cells 3Fast Isolation of Total RNA from Small Numbers of Cells 4Fast Isolation of Total RNA from Small Numbers of Cells 5Fast Isolation of Total RNA from Small Numbers of Cells 6New Competent Cells for Highest Transformation Efficiencies 2New Competent Cells for Highest Transformation Efficiencies 3New Competent Cells for Highest Transformation Efficiencies 4New Competent Cells for Highest Transformation Efficiencies 5New Competent Cells for Highest Transformation Efficiencies 6New Competent Cells for Highest Transformation Efficiencies 7New Competent Cells for Highest Transformation Efficiencies 8Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 2Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 3
... receptors constitute the principal excitatory ... classes of glutamate receptors exist: ... Ionotropic glutamate receptors are oligomeric ... NMDA1-3, KAI-2) which comprise ligand-gated ...
... Block Moto Alpha unit with motorized heated lid ... that is useful for microarrays and chips. The ... blocks. The sealing force of the motorized lid ... to give repeatable results. This interchangeable Moto Alpha ...
Caspr2 Antigen: Fusion protein amino acids 96-1265 (extracellular domain) of human Caspr2 Accession Number: NP_054860...
... N,N- bis- (3-D-Gluconamidopropyl)deoxycholamide ... of CHAPS and CHAPSO. Has reduced electrostatic ... exchange chromatography on DEAE-cellulose. Aggregation number: 8-16. ... in H 2 O. Aggregation number 8 ...
Biology Products: