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Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
Date:7/4/2012

ool and reduce mature blood cells in the bone marrow. The resulting condition creates a situation with similarities to myelodysplastic syndrome one of the precursors to this type of leukemia.

"This is one of the most common mutations in AML," says Dr. Mak. "We also found that it is the common mutation in about 40% of a specific type of lymphoma." The mutation is also known to be involved in about 70-90% of low-grade brain cancers (glioblastomas gliomas) and a variety of other cancers.

Dr. Mak's interest in the blood system began as a young researcher three decades ago with Drs. Ernest McCulloch and James Till, the acclaimed "fathers of stem cell science" at Ontario Cancer Institute, the research arm of Princess Margaret Hospital, whose 1961 discovery of stem cells launched the new field.


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Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2

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