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Cancer scientists discover new way breast cancer cells adapt to environmental stress
Date:5/14/2011

ood in order to flourish where healthy cells would not survive."

"Our discovery that deprivation of either sugar or oxygen spurs CPT1C expression in tumour cells marks this protein as a potential target for new drug development," says Dr. Mak.

"We also demonstrated that cells that were prevented from using CPT1C to cope with a disruption in sugar metabolism became more sensitive to environmental stress. These findings represent an important stepping stone to developing targeted therapies that can block cancer cells from adapting to environmental challenges and surviving efforts to kill them."

This most recent discovery builds on Dr. Mak's impressive body of work, which has led to important breakthroughs in immunology and our understanding of cancer at the molecular level. Dr. Mak is internationally renowned for his 1984 landmark scientific paper on the cloning of the genes for the T cell receptor, a key component of the human immune system.


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Contact: Geoff Koehler
geoff.koehler@uhn.on.ca
416-340-4800
University Health Network
Source:Eurekalert

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