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Cancer-resistant mouse discovered
Date:11/26/2007

ents without the toxic and damaging side effects of chemotherapy and radiation therapy.

"When a cancer patient goes to the clinic, they undergo chemotherapy or radiation and there are potential side effects associated with these treatments," Rangnekar said. "We got interested in looking for a molecule which will kill cancer cells and not kill normal cells, but also would not be toxic with regard to the production of side effects to the entire organism. We are thinking of this in a holistic approach that not only would get rid of the tumor, but also not harm the organism as a whole. Before this animal study, we published a lot of work indicating that in cell culture, there's no killing of normal cells. This is the proof that it doesnt kill normal cells because the mouse is alive and healthy."

Rangnekar admits there is much more work to be done before this research can be applied to humans, but agrees that is the most logical next step.

"I look at this research from the standpoint of how it can be developed to the benefit of the cancer patient and that's really what keeps us focused all this time," said Rangnekar. "If you look at the pain that cancer patients go through, not just from the disease, but also from the treatment it's excruciating. If you have someone in your family, like I did, who has gone through that, you know you can see that pain. If you can not only treat the cancer, but also not harm the patient, that's a major breakthrough. That's happening with these animals and I think that's wonderful."


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Contact: Amy Ratliff
amy.ratliff@uky.edu
859-323-6363
University of Kentucky
Source:Eurekalert

Page: 1 2

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