Navigation Links
Cancer-resistant mouse discovered
Date:11/26/2007

LEXINGTON, Ky. (November 27, 2007) − A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate.

The researchers discovered that the Par-4 gene kills cancer cells, but not normal cells. There are very few molecules that specifically fight against cancer cells, giving it a potentially therapeutic application.

Funded by several grants from the National Institutes of Health, Rangnekar's study is unique in that mice born with this gene are not developing tumors. The mice grow normally and have no defects. In fact, the mice possessing Par-4 actually live a few months longer than the control animals, indicating that they have no toxic side effects.

"We originally discovered Par-4 in the prostate, but it's not limited to the prostate. The gene is expressed in every cell type that we've looked at and it induces the death of a broad range of cancer cells, including of course, cancer cells in the prostate," said Rangnekar. "The interesting part of this study is that this killer gene is selective for killing cancer cells. It will not kill normal cells and there are very, very few selective molecules out there like this."

To further investigate the potential therapeutic benefits of this gene, Rangnekar's team introduced it into the egg of a mouse. That egg was then planted into a surrogate mother.

"The mouse itself does not express a large number of copies of this gene, but the pups do and then their pups start expressing the gene," Rangnekar said. "So, we've been able to transfer this activity to generations in the mouse."

The implications for humans could be that through bone marrow transplantation, the Par-4 molecule could potentially be used to fight cancer cells in pati
'/>"/>

Contact: Amy Ratliff
amy.ratliff@uky.edu
859-323-6363
University of Kentucky
Source:Eurekalert

Page: 1 2

Related biology news :

1. A computer for your mouse!
2. Immune cells promote blood vessel formation in mouse endometriosis
3. New, more direct pathways from outside the cell-to-cell nuclei discovered
4. New continent and species discovered in Atlantic study
5. Ancient organisms discovered in Canadian gold mine
6. New golden frog discovered in remote region of Colombia
7. Antioxidant to retard wrinkles discovered by Hebrew University researcher
8. One species entire genome discovered inside anothers
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
11. How schizophrenia develops: Major clues discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... -- Fingerprint Cards (FPC) has received an ... distributor World Peace Industrial Group (WPI), part of WPG ... major part of the shipments will take place during ... manufacturers in China . The order ... revenue guidance of + 1 000 MSEK for 2015.  ...
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... PALM BEACH GARDENS, Fla. , March 24, ... of biometric identity management solutions, today announced that ... enabling premium clothing accessory retailer Goorin Bros ... login. The Crossmatch biometrics-based solution secures access to ... customers from the increased risk of data breaches. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... at high latitudes grow better than their counterparts closer ... The study, published in the February issue of The ... Bergmann,s Rule, the observation that animals tend to be ... Bergmann made his observation about latitude and size in ...
... Centers for Disease Control and Prevention, the U.S. Food and ... and Inspection Service are investigating a multistate outbreak of Salmonella ... University of Iowa confirmed on Monday, Jan. 25, that this ... sickened 187 people in 39 states (one case in Iowa) ...
... Professor of Philosophy at Stevens Institute of Technology, was recently ... 2009 in History of Science by the History of Science ... Letters at Stevens, was co-author of the paper, "After the ... wrote the paper with Angela N. H. Creager, a Professor ...
Cached Biology News:Better food makes high-latitude animals bigger 2Hygienic Lab at U. Iowa first to confirm salmonella in nationwide outbreak 2
(Date:4/29/2015)... BRM) ("Biorem" or "the Company") today announced its results for the three ... financial statements and MD&A have been filed on SEDAR ( www.sedar.com ). ... 2014 , 2013 Revenue 3,968 , 5,121 ... 1,703 , 2,231 , 5,866 Operating  expenses ... , 4,562 Ebitda* 92 , 418 , ...
(Date:4/29/2015)... 29, 2015 Cambrex Corporation (NYSE: CBM ) ... on Friday, May 1, 2015 before the market opens. ... will host a conference call to discuss the financial results. ... , Friday, May 1, 2015 at 8:30 a.m. ... for U.S.1-719-325-2454 for International  Passcode:  7993632 Dial-in Replay: ...
(Date:4/29/2015)... The leading Regenerative Veterinary Medicine Company, VetStem ... cell therapy has processed more than 11,000 samples. ... successful treatment for horses with potentially fatal injuries to ... worldwide exclusive license for adipose-derived (fat derived) stem cell ... treated in January 2004. Shortly after, the first dogs ...
(Date:4/29/2015)... 2015 /CNW/ - Northern Biologics Inc., a privately held ... an exclusive, strategic collaboration with Celgene Corporation.  As ... US$30 million upfront cash payment. It will use ... antibodies, and will have the right to receive ... its portfolio. Under the agreement, ...
Breaking Biology Technology:Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 2Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 3Biorem Reports Results for Fourth Quarter 2014 and Year Ended December 31, 2014 4VetStem Biopharma -Regenerative Cell Therapy has processed over 11,000 samples 2Northern Biologics and Celgene Enter Strategic Collaboration 2
... Nektar Therapeutics,(Nasdaq: NKTR ) announced today that ... NKTR-102 in platinum-resistant ovarian cancer. Regulatory approvals,have also ... additional,trials: a randomized Phase 2 study to evaluate NKTR-102 ... gene mutation, and a,Phase 2 study in metastatic breast ...
... - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ... has been granted its 31st U.S. Patent, # ... The patent includes claims to pharmaceutical compositions containing ... our proprietary position for REOLYSIN(R)," said Mary Ann ...
... Support Development of Micromet,s EpCAM-specific Antibody Therapeutics BETHESDA, ... (Nasdaq: MITI ), a biopharmaceutical company ... cancer, inflammation and autoimmune diseases today announced the ... Nature Cell Biology (1) revealing a novel ...
Cached Biology Technology:First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer 2First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer 3First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer 4Oncolytics Biotech Inc. Announces Issuance of 31st U.S. Patent 2Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling 2Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling 3Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling 4
KNP-1 (HES1) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 35, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
... E978 GenBank Accession ... Immunogen : NY-ESO-1 full-length ... ascites with 0.05% sodium ... evaluated by immunoblot on ...
NATIVE RAT OSTEOCALCIN...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
Biology Products: