Navigation Links
Cancer-resistant mouse discovered
Date:11/26/2007

LEXINGTON, Ky. (November 27, 2007) − A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the prostate.

The researchers discovered that the Par-4 gene kills cancer cells, but not normal cells. There are very few molecules that specifically fight against cancer cells, giving it a potentially therapeutic application.

Funded by several grants from the National Institutes of Health, Rangnekar's study is unique in that mice born with this gene are not developing tumors. The mice grow normally and have no defects. In fact, the mice possessing Par-4 actually live a few months longer than the control animals, indicating that they have no toxic side effects.

"We originally discovered Par-4 in the prostate, but it's not limited to the prostate. The gene is expressed in every cell type that we've looked at and it induces the death of a broad range of cancer cells, including of course, cancer cells in the prostate," said Rangnekar. "The interesting part of this study is that this killer gene is selective for killing cancer cells. It will not kill normal cells and there are very, very few selective molecules out there like this."

To further investigate the potential therapeutic benefits of this gene, Rangnekar's team introduced it into the egg of a mouse. That egg was then planted into a surrogate mother.

"The mouse itself does not express a large number of copies of this gene, but the pups do and then their pups start expressing the gene," Rangnekar said. "So, we've been able to transfer this activity to generations in the mouse."

The implications for humans could be that through bone marrow transplantation, the Par-4 molecule could potentially be used to fight cancer cells in pati
'/>"/>

Contact: Amy Ratliff
amy.ratliff@uky.edu
859-323-6363
University of Kentucky
Source:Eurekalert

Page: 1 2

Related biology news :

1. A computer for your mouse!
2. Immune cells promote blood vessel formation in mouse endometriosis
3. New, more direct pathways from outside the cell-to-cell nuclei discovered
4. New continent and species discovered in Atlantic study
5. Ancient organisms discovered in Canadian gold mine
6. New golden frog discovered in remote region of Colombia
7. Antioxidant to retard wrinkles discovered by Hebrew University researcher
8. One species entire genome discovered inside anothers
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues
11. How schizophrenia develops: Major clues discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... food, but they also need protection from its harmful rays, ... molecules in plants that shields them from sun damage. Now, ... Chemical Society , one team reports on the mechanics of ... colleagues at Purdue University note that the harsh ultraviolet radiation ... plant DNA and, as a result, hinder plant growth. ...
(Date:10/29/2014)... nanoparticles is all the rage. Thousands of scientists worldwide ... of whether titanium dioxide nanoparticles from sun creams can ... carbon nanotubes from electronic products are as hazardous for ... nanoparticles in food can get into the blood via ... research funds are flowing – and the number of ...
(Date:10/29/2014)... – As bodies decompose, their types and numbers ... they provide could mean the difference between a ... State University is using a more than $866,000 ... death-scene investigators examine these changing populations. The microbial ... location of death, gender, race, socioeconomic relations and ...
Breaking Biology News(10 mins):Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3MSU partners with Detroit to investigate death scenes 2
... 2010 - Novocure reported today that patients with advanced ... in survival time when tumor treating fields (TTF) therapy ... outcomes for patients receiving chemotherapy alone. Dr. Miklos Pless, ... center in Switzerland, presented the data at the European ...
... have reported direct evidence that taking up smoking results in ... results were reported at the 35th Congress of the European ... link between smoking and cancer has been established for decades, ... Institute of Cancer Studies, Birmingham, who presented the results. Smoking ...
... at Chicago College of Medicine have found how gene expression ... unusual types of breast tumors. Their findings may offer new ... 8 issue of the Journal of Biological Chemistry, ... Approximately 70 percent of breast cancers express the estrogen receptor. ...
Cached Biology News:Novocure reports data showing TTF therapy in combination with chemotherapy has the potential to increase overall survival for patients with advanced non-small cell lung cancer 2Study reveals cancer-linked epigenetic effects of smoking 2Clue to unusual drug-resistant breast cancers found 2
(Date:10/30/2014)... 30, 2014 Spartan Bioscience announced today ... CYP2C19 System . It detects CYP2C19 genetic mutations in ... , The Spartan RX CYP2C19 System is the first ... approved in Canada. Due to the system’s ease of ... used by healthcare professionals such as doctors, nurses, pharmacists, ...
(Date:10/30/2014)... Avure Technologies celebrates a year of success and ... its fleet of high volume High Pressure Processing (HPP) systems. ... return to PackExpo this year, which is where we first ... Jeff Williams, CEO at Avure. “Sales of the new Avure ... meeting the challenges of market demand for higher throughput. We ...
(Date:10/30/2014)... 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ... will present a company overview at the Nomura Biotechnology Conference ... Boston, MA. A live ... & Media" section of the Company,s website, www.isispharm.com .  ... 48 hours and will be archived for a limited time. ...
(Date:10/30/2014)...  Regado Biosciences, Inc. (Nasdaq: RGDO ), ... and live audio webcast on Thursday, November 6, 2014, ... 2014 financial results. Interested participants and investors ... for domestic callers or (412) 902-4276 for international callers. ... investor relations section of the Regado website at ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2
... siRNA expression construct into a variety of mammalian cells ... , ... Modified CMV promoter efficiently expresses hairpin siRNAs , ... , Efficient delivery of siRNA or an siRNA , ...
... In the past few years, interest in the , ... small RNA molecules has , ... interrelated lines of research. In one, small double-stranded , ... (siRNAs) have been , ...
... Dicer and Escherichia coli RNase III can be used ... cleave long dsRNA, producing siRNA cocktails that are , ... endoribonuclease that contains RNase III domains and is the , ... of long dsRNAs to siRNA in the , ...
Cached Biology Technology:Delivering siRNA Using Adenoviral Vectors 2Delivering siRNA Using Adenoviral Vectors 3Delivering siRNA Using Adenoviral Vectors 4Detecting miRNA & siRNA 2Detecting miRNA & siRNA 3Detecting miRNA & siRNA 4Detecting miRNA & siRNA 5Detecting miRNA & siRNA 6Detecting miRNA & siRNA 7Detecting miRNA & siRNA 8Detecting miRNA & siRNA 9Dicer vs. RNase III for Preparation of siRNA Cocktails 2Dicer vs. RNase III for Preparation of siRNA Cocktails 3
... Signet offers the most comprehensive, cost-effective ... We have incorporated unprecedented quality into ... This includes proven detection chemistries and ... the TechMate protocol. It also includes ...
... Detection System combines the indirect labeling ... and Signets unique formulation of ultra ... reliablility. Signet reagents will achieve excellent ... automated protocols. ,Signets USA Detection reagents ...
... Level 2 Detection System combines the ... bonding principle and Signets unique formulation ... specificity and reliablility. Signet reagents will ... manual and automated protocols. ,Signets ...
Each bottle contains: Bromophenol Blue 0.25% w/v , Xylene Cyanol FF 0.25%, Glycerol solution 30% w/v...
Biology Products: