Navigation Links
Cancer-related pathways reveal potential treatment target for congenital heart disease
Date:2/21/2011

Cross-disciplinary teams of scientists studying genetic pathways that are mutated in many forms of cancer, but which also cause certain forms of congenital heart disease including hypertrophic cardiomyopathy (HCM), a thickening of the heart muscle that is the leading cause of sudden death in children and young adults , have introduced these mutations into mice and successfully treated HCM in the lab.

In two separate but related studies at University Health Network (UHN), Toronto, and Beth Israel Deaconess Medical Centre (BIDMC), Boston, the scientists proved that two drugs one already approved as an immunosuppressant, the other being tested as an anti- cancer agent could prevent and reverse HCM in mouse models of congenital heart disease.

The research findings are published online today ahead of the March issue of the Journal of Clinical Investigation (manuscript # 44929). Both studies were co-led by UHN's Dr. Benjamin Neel, Director, Ontario Cancer Institute, which includes The Campbell Family Cancer Research Institute. Dr. Neel is also a Professor, Department of Medical Biophysics, University of Toronto, and holds a Canada Research Chair in Cell Signaling.

"By studying two of the most commonly mutated pathways in cancer, discerning the mechanism by which they cause congenital disease, and treating two of these disorders with different drugs, we have identified potential therapeutic targets for human disease," says Dr. Neel. "This is what personalized medicine is all about: understanding in detail how different mutations cause disease, and then targeting these mutations appropriately to tailor individualized treatment."

He adds: "These findings exemplify the importance of basic biological research and collaboration across areas of specialization. In this instance, collaboration showed how understanding cancer can lead to unexpected insights into congenital heart disease, and vice versa."

The scientists
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New clues to how cancer-related proteins plasmin, thrombin lose inhibition
2. Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability
3. Bipolar disorder genes, pathways identified by Indiana University neuroscientists
4. Nicotine activates more than just the brains pleasure pathways
5. Computational model examines the pathways of Alzheimers that strikes at the young
6. Computational model examines the pathways of Alzheimers that strikes at the young
7. Trans fats hinder multiple steps in blood flow regulation pathways
8. UCSF researchers identify 2 key pathways in adaptive response
9. Scientific pathways into the nanoworld
10. Mapping out pathways to better soybeans
11. AgriLife scientist: Functional amino acids regulate key metabolic pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... -- High crime rate, increasing government ... control systems market in Saudi Arabia ... report by TechSci Research " Saudi Arabia Access Control Systems Market ... market in Saudi Arabia is ... systems market in the Kingdom is growing at a ...
(Date:4/14/2015)... 14, 2015  HYPR Corp. today announced it ... ) Alliance tm , an industry consortium transforming ... to share technology and collaborate to deliver open ... more secure and private, and easier to use. ... that protects sensitive user information and eliminates the ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2
... PITTSBURGH , July 8 Geisinger Health System,s pharmacy ... the use of Aethon,s MedEx system, the first advanced automated tracking ... , , ... robots, automatic robotic delivery devices that move equipment and supplies throughout ...
... WORCESTER, Mass. The ability to combat some age-related ... scientists unlocking clues about the molecular and cellular processes ... healthy portion of an individual,s life span can be ... diseases. In the search to understand these molecular processes, ...
... at Barrow Neurological Institute is leading the global discussion and ... insula. A.D. "Bud" Craig, PhD, who began studying ... and edited a special edition of the journal Brain ... scientific interest in the insula. This special edition contains ...
Cached Biology News:Geisinger Implements MedEx System to Enhance Medication Delivery, Tracking 2Geisinger Implements MedEx System to Enhance Medication Delivery, Tracking 3Biologists identify a new clue into cellular aging 2Barrow scientist leads insula research 2
(Date:5/26/2015)... Regenestem Network has announced the grand opening ... Argentina. The clinic will be lead by Silvina Pastrana, ... a multidisciplinary team of medical professionals who specialize in ... office. , The new Regenestem Network members plan ... in cellular therapies, and establish Regenestem protocols to isolate ...
(Date:5/26/2015)... 26, 2015  Sangamo BioSciences, Inc. (NASDAQ: SGMO ) ... CEO, will provide an update on the progress of Sangamo,s ... the company,s business strategy at 1:30pm ET on Monday, June ... conference is being held in New York, NY ... and may be accessed via a link on the Sangamo ...
(Date:5/26/2015)... 2015 OHAUS Corporation, a leading manufacturer ... set to release a new line of Water Analysis ... For over a century, the OHAUS brand has been ... the world. Now in North America, OHAUS is ... to include water quality measurement. The OHAUS Starter Series ...
(Date:5/26/2015)... 26. mája 2015 Kevin Xu ... rodiny prezidentom Barackovi Obamovi a Billovi Clintonovi za ... stratou Dr. Rongxiang Xu , otca Kevina. ... Dr. Xu bol pionier, inovátor, humanitárny ... odhodlanie v oblasti vedy a príkladné vedenie svojej ...
Breaking Biology Technology:Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 2Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 3Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2OHAUS Corporation to Release New Water Analysis Meters in 2015 2OHAUS Corporation to Release New Water Analysis Meters in 2015 3Dr. Rongxiang Xu, O legende 2
... income tax cuts are among the proposals introduced as part ... of lawmakers headed by State Sen. Ted Kanavas , ... initiative, nanotechnology tax credits, and other proposals to stimulate investment, ... the 2007 tax year. Under the measure, all income tax ...
... Wis. - The Midwest is emerging as a ... nearly all of their investments on the coasts, according ... Cleveland-based non-profit organization. , ,The report said the Midwest ... care-related investments. In total, 135 companies raised $792 million ...
... Madison, Wis. - In a visit to one of Dane ... will ask lawmakers to provide $30 million in funding to help ... level of commitment be enough? , ,Doyle, speaking at the east ... announcement in advance of his State of the State address. In ...
Cached Biology Technology:Kanavas outlines new Invest Wisconsin agenda 2Kanavas outlines new Invest Wisconsin agenda 3Midwest hotter for healthcare investments 2Midwest hotter for healthcare investments 3Doyle seeks $30M for e-medical record adoption 2Doyle seeks $30M for e-medical record adoption 3
Extra Large bottle for hybridization 300 x 70mm...
Request Info...
... is TWO ROTORS in ONE! Now, you ... can spin both 1.5 - 2.0 ml ... design provides excellent chemical resistance and can ... fully compatible with common decontamination methods, including ...
... compatible with hood installations. ... system for 384-well plates, ... prepares large quantities of ... Wellpro also performs plate ...
Biology Products: