Navigation Links
Cancer protein's surprising role as memory regulator

BOSTON--Scientists at Dana-Farber Cancer Institute and Harvard Medical School have found that a common cancer protein leads a second, totally different life in normal adult brain cells: It helps regulates memory formation and may be implicated in Alzheimer's disease.

Cyclin E is a well-known culprit that drives many types of solid tumors and blood cancers. The report, published online in Developmental Cell, is the first revelation that cyclin E has a crucial role in the formation of nerve connections, or synapses, in the brain. Synapses are tiny connections between brain cells where memories are stored.

"This protein has a double life," said Peter Sicinski, PhD, a cancer biologist at Dana-Farber and senior author of the publication. "It is overexpressed in many different cancers, but it also is expressed in high levels in the human brain. We have found that cyclin E is needed for memory formation and is a very important player."

The researchers found potential evidence linking cyclin E to Alzheimer's disease, because it binds to an enzyme called Cdk5 that is involved in memory.

"There is good evidence that hyperactivity of Cdk5 contributes to Alzheimer's disease and inhibiting this enzyme can ameliorate symptoms in animals," said Sicinski, who is also a professor of Genetics at Harvard Medical School. "Manipulating cyclin E levels might be another way to accomplish this."

The scientists didn't test cyclin E in Alzheimer's mice, but they did show that when cyclin E binds to Cdk5 molecules, it locks them away in an unusable form. Moreover, when the researchers reduced cyclin E levels in mouse brain cells, fewer nerve connections formed and the animals' memories suffered.

Cyclins are a family of related proteins found in dividing cells. They serve as biological switches, controlling a cell's progression from one phase of its life cycle to the next. The actual signals to exit one phase and enter the nex

Contact: Bill Schaller
Dana-Farber Cancer Institute

Page: 1 2

Related biology news :

1. UCLA researchers develop system that finds prostate cancer spread earlier than conventional imaging
2. Another step toward resisting breast cancer
3. SuviCa Inc. of Boulder to commercialize CU-Boulder cancer screening technology
4. Soy peptide + chemo drug block colon cancers spread to liver
5. Oncologists recognized by ESMO for outstanding contributions to cancer research and treatment
6. Purdue technology used in first fluorescence-guided ovarian cancer surgery
7. AACR to host conference on the science of cancer health disparities
8. MU researchers unveil new method for detecting lung cancer in Nature article
9. Protein found in heart may be target for colon cancer therapies
10. Plant compound reduces breast cancer mortality
11. Primary component in turmeric kicks off cancer-killing mechanisms in human saliva
Post Your Comments:
Related Image:
Cancer protein's surprising role as memory regulator
(Date:10/2/2015)... , Oct. 02 2015 ... the "Enforcing the Law Using Biometrics" ... ) has announced the addition of the ... their offering. --> Research and Markets ... the "Enforcing the Law Using Biometrics" ...
(Date:9/30/2015)... , Sept. 30, 2015  The U.S. Court of ... another key ruling in favor of Crossmatch ™, ... fingerprint scanner company Suprema and its U.S. partner Mentalix ... a trade provision that declares it unlawful to engage ... infringing two of Crossmatch,s patents, the 5,900,993 patent and ...
(Date:9/29/2015)... is excited to be named one of the first 100 ... announcement was recently made at an invite-only IBM Watson: ... Francisco , where iDAvatars presented a demo of its ... "It is both an honor and a privilege to be ... the cognitive power of IBM Watson in our product, which ...
Breaking Biology News(10 mins):
... Energy (DOE),s Joint BioEnergy Institute (JBEI) have identified a potential ... diesel engines but would be clean, green, renewable and produced ... a JBEI research team engineered strains of two microbes, a ... a member of the terpene class of chemical compounds that ...
... Clemson University researchers recently reported finding a new class ... how cells repair damaged DNA. The finding from Cao,s ... with computational chemist Brian Dominy appeared in the Sept. ... "A new family of deamination repair enzymes in ...
... Five new research projects announced today (27 September) by ... to overcome some of the fundamental limitations of photosynthesis ... the sun. This research could lead to major increases ... of renewable chemicals. Just over 2M has been ...
Cached Biology News:
(Date:10/8/2015)... Oct. 8, 2015  ATCC, the premier global biological ... has been selected by The Michael J. Fox Foundation ... to academic, pharmaceutical, and biotechnology organizations committed to speed ... the United States , and more than 5 ... the United States , and more than 5 ...
(Date:10/8/2015)... Maryland , October 8, 2015 ... .   --> Goldman Small ... in the small cap and microcap sectors, announced ... research report on PharmaCyte Biotech, Inc. (OTCQB - ... focused on developing and preparing treatments for cancer ...
(Date:10/8/2015)... WILMINGTON, Del. , Oct. 8, 2015 /PRNewswire/ ... of CRISPR-Cas technologies for genome editing, jointly announced ... DuPont and Caribou have cross-licensed their respective patent portfolios, ... CRISPR-Cas technology applications in major row crops, and ... applications. --> ...
(Date:10/8/2015)... , Oct. 8, 2015  Today the Wyss Institute ... launch of its start-up company Opsonix Inc. ... Harvard,s Office of Technology Development (OTD) and ... sepsis therapy for clinical use. ... least a million people every year in the U.S. ...
Breaking Biology Technology:
... Corp.,(Nasdaq: GENZ ) today announced that the ... for Renvela(TM) (sevelamer carbonate) for,the control of serum ... Renvela is a next-generation version of Renagel(R) (sevelamer,hydrochloride), ... "Since its approval in 1998, Renagel has ...
... Capital Holdings Asia and,its co-investors today announced that ... Corporation, the world,s largest privately held,crop- protection and ... 250 billion (US$2.2 billion). The sale will culminate ... market private,equity firm with investment teams in Japan, ...
... Oct. 22 AMDL, Inc. (Amex:,ADL), headquartered ... and Jilin, China, through its wholly owned ... biopharma company that,engages in the development, manufacture ... AMDL announced today that its,management will present ...
Cached Biology Technology: