Navigation Links
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Date:11/22/2009

y called cancer metabolism, which focuses on studying profound changes in metabolic activity in cancer cells. Through a mix of large-scale profiling of hundreds of cellular metabolites, x-ray crystallography, and innovative enzymology, the Agios team demonstrated that a single amino-acid substitution in the IDH1 active site allows the enzyme to acquire an entirely new activity to produce the metabolite 2HG. Analysis of tumor samples of brain cancer patients with the IDH1 mutation revealed up to hundred-fold elevations in concentrations of 2HG, a metabolite that has been previously linked to the formation of brain cancer.

"Agios' founding principles included the belief that targeting important metabolic pathways of cancers could make a fundamental difference in the treatment of the disease. Our IDH1 discovery is a great example of the power of the team and of our approach in targeting cancer metabolic pathways. In just four months, scientists at Agios unraveled very complex biology to advance a new understanding of gliomas and the role of IDH1 and corresponding biomarkers," said David Schenkein, M.D., Chief Executive Officer, Agios. "We are able to do this by utilizing a unique approach of integrating deep biology and leveraging our proprietary platform for cancer metabolism research.

"We are looking forward to developing potential therapeutics specifically targeting IDH1 for patients with these devastating diseases, and to leveraging our unique cross functional approach to cancer metabolism research in order to discover insights into other targets and pathways," added Schenkein.

About the metabolic enzyme IDH1 and its role in cancer

Recent research has linked mutations in the metabolic enzyme IDH1 to glioma and other cancers.[2] Approximately 70 percent of gliomas are known to have the IDH1 mutation. Recently, the IDH1 mutation was also shown to be present in a significant percentage of patients with Acute Myeloid Leuke
'/>"/>

Contact: Kathryn Morris
kathryn@kmorrispr.com
845-635-9828
Yates Public Relations
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. Protein chatter linked to cancer activation
5. Newly created cancer stem cells could aid breast cancer research
6. Western diet linked to increased risk of colon cancer recurrence
7. Obesity and lack of exercise could enhance the risk of pancreatic cancer
8. Low levels of key protein may indicate pancreatic cancer risk
9. Birth records hold pancreatic cancer clue
10. Many parents at-risk for cancer disclose genetic test results to children
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the ... Phase 3 study of Zerenex (ferric citrate), the Company,s ... of hyperphosphatemia in patients with end-stage renal disease (ESRD) ... delivery with FErric CiTrate in EsrD) was published online ... of Nephrology ( JASN ). , ...
(Date:7/24/2014)... has different effects on different species of fish, ... of Bristol and Exeter which tested fish anti-predator ... a flying seagull predator model when exposed to ... European minnows. , Lead author Dr Irene ... "Noise levels in many aquatic environments have increased ...
(Date:7/24/2014)... own microbial terroir, meaning the microbial populations found on ... product, creating the final flavor according to research published ... Environmental Microbiology . This is the first time investigators ... , Many sake makers inoculate with both bacteria ... the University of California, Davis, but he and his ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4The microbes make the sake brewery 2
... is pleased to announce the winners of its 2009 ... Plenary Session of the ESA Annual Meeting in Indianapolis, ... be presented on Tuesday, December 15, 7:00-8:00 p.m. ... with full biographies and photos available at http://www.entsoc.org/resources/press_releases/2009-awards.htm ...
... recently completed a comparative analysis of marine ecosystems in ... factors support fisheries production, leading to new insights that ... Known as MENU, for Marine Ecosystems of Norway and ... NOAA Fisheries Service,s Northeast Fisheries Science Center and Alaska ...
... The University of North Carolina at Chapel Hill is ... part of an unprecedented large-scale, collaborative effort by the National ... (NHGRI) to systematically characterize the genomic changes that occur in ... a five-year award, expected to bring $13 to $20 million ...
Cached Biology News:Entomological Society of America names 2009 award winners 2Joint US-Norwegian study provides new insights into marine ecosystems and fisheries production 2Joint US-Norwegian study provides new insights into marine ecosystems and fisheries production 3UNC awarded Cancer Genome Atlas grant 2
(Date:7/24/2014)... to settle into equilibriuma state of unchanging balance ... of non-equilibrium conditions where new possibilities lie. Non-equilibrium ... such as temperature fluctuations, freezing and melting, or ... body temperature, airplanes to fly, and the Earth ... even though these conditions exist naturally and are ...
(Date:7/24/2014)... Research and Markets has announced ... Analytical Instruments Market 2014-2018" report to their offering. ... Genomics is the study of the gene and its ... and functions of proteomes or sets of proteins by ... involves the mapping of genes and DNA sequencing to ...
(Date:7/24/2014)... 2014 SRI International has been awarded a ... of Allergy and Infectious Diseases (NIAID), part of the ... potential therapies for HIV infection and AIDS. The contract ... AIDS and the complications and opportunistic infections associated with ... transmission of HIV. According to the ...
(Date:7/24/2014)... 2014 Three companies from the angelMD ... Big C Competition. Out of 700 competition entrants, Chiron ... the semi-final round. In this round twenty teams are ... complete with mentoring from thought-leaders and medical entrepreneurs from ... the angelMD commitment to the Livestrong vision around the ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 33 angelMD Startups Make Livestrong Big C Semi-finals 2
... - Ranked Number 7 out of top 20 Employers ... 9 EMD Serono, Inc., an affiliate,of Merck KGaA, ... Science magazine as a top employer in the biotechnology ... 20 employers,across the life sciences., "We are honored ...
... (Nasdaq: ERES ), a leading provider of ... to the pharmaceutical,biotechnology, medical device, and related industries, ... quarter results for the period ended,September 30, 2008 ... closes.,After the release, the Company will host a ...
... Million RMB Commercial Bank Loan With Interest Payment ... Biotech Ltd. (Amex:,SVA), a vaccine-focused biotech company in ... Promotion Association at the,Zhongguancun Science and Technology Park ... of that program, Sinovac Biotech Co. Ltd.,s,("the Company") ...
Cached Biology Technology:EMD Serono Named as a Top Employer by Science Magazine 2eResearchTechnology, Inc. to Announce 2008 Third Quarter Results on October 30, 2008 2Sinovac's Credit Rating Upgraded to AAZ, Second Highest Rating 2Sinovac's Credit Rating Upgraded to AAZ, Second Highest Rating 3
... 2000 instrument can be used as a ... Data Manager Software provides the means to ... the instrument. These data can then be ... such as Microsoft Excel or Lotus 123, ...
... designed for the study of protein:protein interactions ... Proteins that interact with GST•Tag™, S•Tag™, ... copurified using affinity resins for the tags, ... spin filter. The complexes are eluted with ...
... (V2), 22K is useful for investigating plant organ ... contains content derived from the ATH1 v. 3 ... and represents 21,500 genes. ... glass slides each containing an identical 22K oligonucleotide ...
... Using multicolor analysis in a modern ... of cells that are differentially labeled with ... the dyes typically used for cell labeling ... generated by a flow cytometers filters. Thus, ...
Biology Products: