Navigation Links
Cancer immunotherapy shows long-term promise in lung cancer
Date:4/24/2008

New, long-term results from a clinical trial presented today at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association of the Study of Lung Cancer (IASLC) show that MAGE-A3 ASCI (Antigen-Specific Cancer Immunotherapeutic), an immune-boosting treatment for lung cancer patients, reduces the risk of relapse after surgery -- to the same extent as chemotherapy but without the side-effects of chemotherapy.

Prof. Johan Vansteenkiste from University Hospital Gasthuisberg in Belgium described the results after 44-months follow-up from a double-blind, placebo-controlled trial in 182 patients with non-small-cell lung cancer -- the most common form of the disease.

After complete surgical resection of the tumor, patients were randomly assigned to receive either placebo injections or injections of MAGE-A3 ASCI administered over 27 months (five given at three-week intervals followed by eight given once every three months). MAGE-A3 is a tumor-specific antigen, expressed in 35-50% of non-small-cell lung cancer, but not on normal cells.

"The aim is to help the body immune system to recognize the MAGE-A3 antigen and therefore eliminate the cancer cells that express MAGE-A3," explains Prof. Vansteenkiste. "In other words, it is a kind of treatment method that makes the body immune system specifically attack the lung cancer cells."

After 44 months, 69 of 182 patients had experienced a recurrence of their cancer, including 57 deaths. Those given the MAGE-A3 injections had longer on average before their cancer recurred, were less likely to have any recurrence, and were less likely to die.

"Surgical resection is the standard treatment for patients with early stage lung cancer, but after complete resection about 50% will relapse and die from their cancer," says Prof. Vansteenkiste. "Postoperative chemotherapy is able to improve cure rates, but is someti
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
41-919-731-907
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers reveal structure of protein that repairs damage to cancer cells
2. Pregnancy is possible after cancer treatment
3. Effective cancer immune therapy through order in the blood vessels
4. Fox Chase researchers discover a method for clamping down on a cancer-promoting enzyme
5. Breast cancers behave differently before and after the age of 70
6. Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer
7. Ovarian cancer stem cells identified, characterized
8. Inherited cancer mutation is widespread in America
9. New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks
10. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
11. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... The "brush border" a densely packed array of ... the cells that line our intestines., Vanderbilt University researchers ... structure, which is critical for absorbing nutrients and defending ... journal Cell , reveal a role for adhesion ...
(Date:4/16/2014)... thoughts and feelings are the result of neurons talking ... of the conversations might not be all that private. Brain ... even participating in, some of those discussions. But a new ... part of the time specifically, when the neurons get ...
(Date:4/16/2014)... to conquer the world? Surprisingly, bacteria also face this ... now shown how these organisms should decide how best ... subtilis is quite adaptable. It moves about in ... Alternatively, it can stick to an underlying substrate. Actually, ...
Breaking Biology News(10 mins):Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 3Eavesdropping on brain cell chatter 2Eavesdropping on brain cell chatter 3Theoretical biophysics: Adventurous bacteria 2
... German . , Tobias Brgmann and his colleagues from the ... for their experiments, which is a type of light sensor. At ... the cell membrane. When stimulated with blue light, this channel opens, ... in the cell membrane,s pressure, which stimulates cardiac muscle cells to ...
... towards the poles almost everywhere in the world, except ... and snails Steffen Kiel and Sven Nielsen at the ... pattern originated at the end of the last ice ... created a mosaic landscape of countless islands, bays and ...
... rich in walnuts and walnut oil may prepare the body ... Penn State researchers who looked at how these foods, which ... stress., Previous studies have shown that omega-3 fatty acids -- ... seeds -- can reduce low density lipoproteins (LDL) -- bad ...
Cached Biology News:Bonn researchers use light to make the heart stumble 2Disappearing glaciers enhanced biodiversity 2Walnuts, walnut oil, improve reaction to stress 2Walnuts, walnut oil, improve reaction to stress 3
(Date:1/15/2014)... , January 15, 2014 A study has ... on the Formula 1 track could help to tackle the ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) and ... provider Simplyhealth. Telemetry technology, which is inspired by ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... Highlighted by Cinryze(TM) [C1 Inhibitor (human)] Commercial Launch --EXTON, Pa., ... reported today its financial results for the fourth quarter and ... include:Operational: , , , ... Inc. (Lev) in October 2008; , ...
... Feb. 24 Mach One Corporation (Pink Sheets: MNCN), ... purchase of Ceres Organic Harvest, Inc. an organic grain ... feed and dairy industries. Ceres Organic Harvest had 2008 ... the stock of Ceres for $8 million in a ...
... (USA) Inc ("MINDSET") a company privately held by MPM ... received a Notice of Allowance in Europe related to ... for the prevention and treatment of memory loss. Drugs ... been approved for the treatment of type II diabetes ...
Cached Biology Technology:ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 2ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 3ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 4ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 5ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 6ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 7ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 8ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 9ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 10ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 11ViroPharma Incorporated Reports Fourth Quarter and Full Year 2008 Financial Results 12Mach One Corporation Completes Acquisition of Ceres Organic Harvest, Inc. 2Mindset BioPharmaceuticals (USA) Inc Obtains Notice of Allowance for European Patent Related to Use of Insulin Sensitizers in Senile Dementia, Dementia and Memory Loss 2Mindset BioPharmaceuticals (USA) Inc Obtains Notice of Allowance for European Patent Related to Use of Insulin Sensitizers in Senile Dementia, Dementia and Memory Loss 3
Request Info...
... Source: E. coli containing a clone of ... Description: Topoisomerase II alters the topological state ... helix through a transient break which generates a ... of its double-stranded DNA passage mechanism, the enzyme ...
Request Info...
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
Biology Products: