Nanobodies produced from camel blood have unique properties, which can be used in future drug development. New research published in Journal of Controlled Release confirms that camel blood can help scientists in the fight against cancer.
Members of the camelid family have particular heavy-chain antibodies. These antibodies can be used to clone nanobodies, which are antibody-derived therapeutic proteins. One of the most powerful advantages of nanobodies is that they can be easily attached to other proteins and nanoparticles by simple chemical procedures.
Scientists at the Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, have designed nanoparticle systems of smaller than 150nm that are decorated with nanobodies expressing high specificity for the cancer marker Mucin-1, which is connected to breast and colon cancer.
Research supports aim for safer nanomedicines
"This is a very effective and a highly promising approach in experimental cancer gene therapy, while minimising adverse-related reactions to cancer nanomedicines. Futhermore the research supports our aim for rational design and engineering of effective and safer nanomedicines for the future. We have taken the first step, but of course more work is needed to support the efficacy of this system for cancer treatment," says Professor Moein Moghimi.
Professor Moghimi works at the Department of Pharmaceutics and Analytical Chemistry at the Faculty of Pharmaceutical Sciences where he heads the Centre for Pharmaceutical Nanotechnology and Nanotoxicology, which is supported by the Danish Ministry of Science, Technology and Innovation.
The procedures for camel immunisation, generation and purification of the Mucin-1 nanobody were done by Dr. Fatemeh Rahbarizadeh's team at the Medical Biotechnology Department of the Tarbiat Modares University in Tehran. Dr. Rahbarizadeh is currently visiting scientist at the Univers
|Contact: Moein Moghimi|
University of Copenhagen