Navigation Links
Cancer from fetal exposure to carcinogens depends on dose, timing
Date:12/15/2011

CORVALLIS, Ore. The cancer-causing potential of fetal exposure to carcinogens can vary substantially, a recent study suggests, causing different types of problems much later in life depending on the stage of pregnancy when the fetus is exposed.

The research sheds further light on the way in which toxic damage early in life can later manifest itself as cancer, due to "epigenetic" changes in cells. It was done by scientists in the Linus Pauling Institute at Oregon State University, and other institutions, in laboratory studies with mice.

In this study, published in the journal Cancer Letters, mice received four separate doses of a carcinogen commonly found in air pollutants or other combustion products. As a result, they had triple the level of ovarian cancer at the rodent equivalent of middle age. About 80 percent of them also got lung cancer, and many of the male mice had abnormally small testes a phenomenon not seen before.

In previous research, by contrast, the same amount of this carcinogen given in a single dose had caused a much higher rate of T-cell lymphoma, a type of blood cancer, which this study found to almost disappear when the carcinogen exposure was spread out over time. Liver cancer also was largely absent.

"There's still a lot of uncertainty about how the fetus responds to carcinogens and at what points in time it is most vulnerable," said David Williams, a professor of environmental and molecular toxicology at OSU.

"We know it's far more sensitive than adults for several reasons, including faster cell division and the lack of protective detoxifying enzymes," he said. "But it's interesting that the timing of fetal exposure makes such a difference in which organs are targeted. These results were somewhat surprising."

The mice in these experiments were exposed to one type of polycyclic aromatic hydrocarbon, a group of compounds commonly produced by everything from coal combustion to a
'/>"/>

Contact: David Williams
david.williams@oregonstate.edu
541-737-3277
Oregon State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breast cancer treatment resistance linked to signaling pathway
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. The dietary supplement genistein can undermine breast cancer treatment
4. Saliva proteins could help detection of oral cancer
5. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
6. Breakthrough optical technology to assess colon cancer risk, accuracy
7. Breast cancer cells recycle to escape death by hormonal therapy
8. Nanodiamond drug device could transform cancer treatment
9. Second lumpectomy for breast cancer reduces survival rates
10. Study looks at psychological impact of gene test for breast cancer
11. SNM releases new fact sheet on breast cancer and molecular imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich have identified the structural ... discriminate between viral and endogenous RNAs in living ... control of cellular metabolism and hijack cellular resources ... is dependent on viral RNA molecules that are ... viruses) and/or newly synthesized in the host cell, ...
(Date:4/24/2014)... State University and the University of North Carolina at ... could help identify arterial plaque that is at high ... stroke. , At issue is the plaque that builds ... plaque are deemed "vulnerable," meaning that they are more ... heart attack or stroke. , "Existing state-of-the-art technologies are ...
(Date:4/24/2014)... river turtle in North America, weighing in at up ... researchers from Florida and the University of Vermont have ... three. , Examining museum specimens and wild turtles, the ... , Once heavily hunted for turtle meat alligator ... in the 1960s the riverine populations have been ...
Breaking Biology News(10 mins):Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3New ultrasound device may add in detecting risk for heart attack, stroke 2Two new US turtle species described 2Two new US turtle species described 3
... greater role in the disparity between the numbers of ... with the disease. A study by researchers at the ... the disparity was substantially reduced when comparing groups of ... environments. The results are published in the November 2008 ...
... RELEASE LEDs ... Chemical Society Researchers in Germany are describing a ... facial wrinkles. Their study, scheduled for the November 5 ... a bi-monthly journal, reports that high intensity visible light ...
... amyloid-b (Ab), builds up into fibrous plaques in the ... membrane microdomain to another to be cleaved, report Sakurai ... that Ab plaques are the direct cause of Alzheimer,s ... And working on this hypothesis, scientists are investigating just ...
Cached Biology News:Hypertension disparity linked to environment 2American Chemical Society Weekly PressPac Oct. 15, 2008 2American Chemical Society Weekly PressPac Oct. 15, 2008 3American Chemical Society Weekly PressPac Oct. 15, 2008 4American Chemical Society Weekly PressPac Oct. 15, 2008 5American Chemical Society Weekly PressPac Oct. 15, 2008 6American Chemical Society Weekly PressPac Oct. 15, 2008 7American Chemical Society Weekly PressPac Oct. 15, 2008 8
(Date:1/15/2014)... TAIPEI , Jan. 15, 2014 TaiGen Biotechnology ... an exclusive agreement with R-Pharm, a leading Russian pharmaceutical ... in the Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic for ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up ... many of them wrote: "Take better care of my furry companion." ... designer clothes and top-brand carrying cases to take the little canine ... might also feel compelled to buy some pricey toys at the ...
(Date:1/14/2014)... Toronto, Canada (PRWEB) January 14, 2014 ... and its motives and methods in product development and ... of the industry. This mistrust, fueled by concerns about ... further fed by reports of spectacular fines to the ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Kerr Corporation, a ... video and additional how-to information about dual arch impressions on ... with Dual Arch Impressions,” the blog entry serves up a ... and houses a step-by-step demonstration by Dr. David Little as ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Md., Jan. 26 Novavax, Inc. (Nasdaq:, NVAX ... Good Manufacturing,Practice ("GMP") Pilot Plant to manufacture pandemic and ... 1,000 liter scale are,installed and ready for operations supporting ... project was initiated in December 2007. The facility ...
... Inc., a leading provider of enterprise-wide software and ... announced it has entered into a partner referral ... Alcoholism and Substance Abuse Providers (ASAP) for Netsmart ... learning management solution. ASAP is a not-for-profit membership ...
... Battelle for submission of proposals to U.S. Government ... Medical Corporation (OTC Bulletin Board: CONX), a worldwide ... announced a collaboration with Battelle, a Columbus, Ohio-based ... includes national security. Under the collaboration, Corgenix will ...
Cached Biology Technology:Novavax Announces Operational Status of Its Vaccine Pilot Plant and Commercial Launch Facility 2Novavax Announces Operational Status of Its Vaccine Pilot Plant and Commercial Launch Facility 3Novavax Announces Operational Status of Its Vaccine Pilot Plant and Commercial Launch Facility 4Netsmart University Announces Partner Referral Agreement With New York Association of Alcohol and Substance Abuse Providers 2Netsmart University Announces Partner Referral Agreement With New York Association of Alcohol and Substance Abuse Providers 3Corgenix Signs Collaboration With Battelle 2Corgenix Signs Collaboration With Battelle 3
... state-of-the-art separation system using the asymmetric flow ... integrates easily with Wyatts multi-angle light scattering ... as the Optilab DSP. The combined system ... of the particles/molecules separated by the AFFF ...
Monoclonal antibodies conjugated with rhodamine...
... compact and lightweight, the Moticam 2300 camera ... the eyepiece, eyetube, or trinocular port. Included ... use Plug-and-Play Images 2.0ML software offers quick ... tools to maximize resolution for examination or ...
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
Biology Products: