Navigation Links
Cancer drug protects against diabetes
Date:1/9/2014

Very low doses of a drug used to treat certain types of cancer protect the insulin-producing cells in the pancreas and prevent the development of diabetes mellitus type 1 in mice. The medicine works by lowering the level of so-called sterile inflammation. The findings have been made by researchers from the University of Copenhagen, the Technical University of Denmark and the University of Southern Denmark working with researchers in Belgium, Italy, Canada, Netherlands and the USA.

"Diabetes is a growing problem worldwide. Our research shows that very low doses of anticancer drugs used to treat lymphoma so-called lysine deacetylase inhibitors can reset the immune response to not attack the insulin-producing cells. We find fewer immune cells in the pancreas, and more insulin is produced when we give the medicine in the drinking water to mice that would otherwise develop type 1 diabetes," says postdoc Dan Ploug Christensen, who is the first author on the article and responsible for the part of the experimental work carried out in Professor Thomas Mandrup-Poulsen's laboratory at the Department of Biomedical Sciences, University of Copenhagen.

The ground-breaking findings have just been published in the scientific journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

From mice to men

"This type of medicine is already being used against certain cancers, but we used doses which are 100 times lower than those used in cancer treatment and which have been shown to be safe in children with certain rheumatic diseases," says Thomas Mandrup-Poulsen.

"Our results are a step towards developing a preventive treatment for type 1 diabetes," says Dan Ploug Christensen. "It works by blocking the molecules that send the harmful inflammation signals into the insulin-producing cells. In doing so, it prevents the cells from producing a number of factors which contribute to des
'/>"/>

Contact: Dan Ploug Christensen
dploug@sund.ku.dk
45-25-34-55-44
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
2. Novel noninvasive therapy prevents breast cancer formation in mice
3. UTSW study identifies potential therapeutic target for incurable, rare type of soft-tissue cancer
4. International team completes systematic, genomic study of cervical cancer
5. Breast cancer patients experience fewer side effects from anticancer drug when receiving acupuncture
6. A new role for milk: Delivering polyphenols with anti-cancer activity
7. The first cancer operation room with a navigator is created
8. New compound could reverse loss of muscle mass in cancer and other diseases
9. Role for sugar uptake in breast cancer revealed
10. Muscle-invasive and non-muscle invasive bladder cancers arise from different stem cells
11. Spontaneous fusion with macrophages empowers cancer cells to spread
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... JOSE, Calif. , June 17, 2015 /PRNewswire/ ... in human interface solutions, today announced that Xiaomi, ... adopted the Synaptics ® ClearPad ® ... of display driver integrated circuits (DDICs) for its ... Pro. By leveraging ClearPad for full in-cell display ...
(Date:6/16/2015)... June 16, 2015 Fingerprint Cards has ... sensors in the company,s portfolio from one of its module ... to mainly take place during the third quarter 2015. The ... Asia . Jörgen Lantto, CEO of FPC, ... the   growing interest from smartphone OEMs in integrating touch ...
(Date:6/15/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") a ... announces that its leading payment security technology, the Wocket® smart ... NYC June 18th. Digital Experience! @ NYC is ... to over 300 of the top media covering the sector. ... New York City from 6:00 to ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... University of Minnesota Medical School and Masonic Cancer ... to discover how some proteins may cause the development ... part of R-spondin family normally help activate cell ... have discovered that when two types of R-spondins ...
... This press release is available in French , ... . STOCKHOLM (24 AUGUST 2012) As food ... and the "super drought" in the US, a new study finds ... insecurity and climate risks in sub-Saharan Africa and South Asia. The ...
... might have unraveled some lingering evolutionary questions about group ... that took a unique approach to observing interactions between ... in the journal Science some of the ... such as schools of fish can evolve as a ...
Cached Biology News:U of M researchers: Newly discovered genetic markers could signal colon cancer development 2Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 2Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 3Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 4Video-gaming fish play out the advantages of groups 2Video-gaming fish play out the advantages of groups 3Video-gaming fish play out the advantages of groups 4
(Date:7/3/2015)... 3, 2015 ... osoitteessa  http://www.openinnovationinscience.at Wienissä pidettävään ... Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... tekemän, kansainvälisiä tutkijoita ja tiedemiehiä ... suurinta haastetta ovat kannustimien puute ...
(Date:7/3/2015)... 2015 Forskere kan ... in Science", som finner sted i ... nett, på  http://www.openinnovationinscience.at , og søknadsperioden varer ... De to største utfordringene innen helsevitenskapen er ... forskningsspørsmål og kompleksiteten av nåværende forskningsresultater, i ...
(Date:7/2/2015)... College of DuPage students Sam Liesman ... real-world experiences while serving biophysics internships at the prestigious ... students will be working as a part of IIT ... IIT. The internship came about from a discussion between ... Kathy Finan , Biology; and Dr. Wereszczynski regarding ...
(Date:7/2/2015)... ... July 02, 2015 , ... In’Tech Medical ... instruments in Orthopedics, announced today the acquisition of Turner Medical, Inc ., ... of surgical instruments to the Spine Industry. The acquisition of Turner Medical ideally ...
Breaking Biology Technology:Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3COD Students Participate in Prestigious Summer Internships 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3
... Nfocus device development team.PALO ALTO, Calif., April 30 ... today the appointment of accomplished regulatory executive Robert O,Holla ... President of Regulatory Affairs. "Bob O,Holla brings an unmatched ... , having served 18 of his last 30 years ...
... April 30 Idenix Pharmaceuticals, Inc. (Nasdaq: IDIX ... of drugs for the treatment of human viral diseases, today ... 31, 2009. At March 31, 2009, Idenix,s cash, cash equivalents ... , , ...
... Resonant Medical, an innovator in 3D ultrasound image-guided ... Stephen Whisenhunt to the position of Vice President ... the Company,s growing global sales team and manage ... years of radiation oncology industry experience to the ...
Cached Biology Technology:Nfocus Neuromedical Appoints Robert O'Holla to Head Regulatory 2Idenix Pharmaceuticals Reports First Quarter Financial Results 2Idenix Pharmaceuticals Reports First Quarter Financial Results 3Idenix Pharmaceuticals Reports First Quarter Financial Results 4Idenix Pharmaceuticals Reports First Quarter Financial Results 5Idenix Pharmaceuticals Reports First Quarter Financial Results 6Resonant Medical Expands Sales Organization with Appointment of Vice President of Global Sales and Marketing 2
Human peripheral blood CD14+ monocytes, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Yeast tRNA 50 l...
...
...
Biology Products: