Navigation Links
Cancer drug delivery research at Case Western Reserve University cuts time from days to hours
Date:7/22/2008

ted with polyethylene glycol (PEG) ligands, giving it the appearance of a hairy ball, said Burda. These PEG molecules offer several advantages over other materials: they are soluble in fats and water, don't interact with proteins in the bloodstream and help protect the drug, keeping it safe and stable until delivery to the cancer site.

Between each PEG ligand, molecules of a photodynamic chemotherapy drug (Pc 4) are attached to the Au NP. The Pc 4 drug (a phthalocyanine compound) was developed at Case Western Reserve by Malcolm Kenney, professor of chemistry.

When the nanoparticle reaches the cancerous tissue the drug molecules are released and uploaded to the diseased area. Focused red light is used to energize the drug in the patient once it has been delivered to the tumor.

Burda says that a potential future research project would look at providing a time-release administration of the drug rather than a more all-at-once release. In the long term, Burda hopes to make the Au NP delivery system applicable to a broad range of diseases.

The Au NP has a diameter of 5 nm. The addition of PEG ligands expands the total diameter to 32 nm, larger than some other nanoparticles currently in use, but still small enough to pass unencumbered through the bloodstream.

A single 1/4-mL injection holds approximately 100 million Au NPs, each carrying approximately 100 drug molecules.

Tail to Tumor in Two Minutes

In the laboratory of Baowei Fei, assistant professor of radiology and biomedical engineering at Case Western Reserve, these Au NPs have been used to treat mice with cancerous tumors. Once the Au NPs have been injected into the tail, the Pc 4 is uploading into the diseased area within minutes. The accelerated speed of drug administration in mice is due in part to the much more efficient dispersion of the NP delivered drug.

When tested on human cells called HeLa a line of laboratory-grown human cells used in testing most of the dru
'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gene panel predicts lung cancer survival, study finds
2. Researchers discover link between organ transplantation and increased cancer risk
3. Vitamin A pushes breast cancer to form blood vessel cells
4. Smothered genes combine with mutations to yield poor outcome in cancer patients
5. TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer
6. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
7. Colorectal cancer screening rates still too low
8. UCLA researchers locate and image prostate cancer as it spreads to lymph nodes
9. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
10. Control switches found for immune cells that fight cancer, viral infection
11. Prostate cancer vaccines more effective with hormone therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2015)... --  The Sync Project™ today announced the ... harness music to improve health. The platform maps ... of physiology, enabling the study of the therapeutic ... It is designed for medical and health research, ... and accelerate the discovery of the clinical applications ...
(Date:3/10/2015)... 10, 2015   Tute Genomics , pioneer in ... by next-generation sequencing company PrimBio Research Institute ... targeted gene panel interpretation. PrimBio, a certified ... most current technologies to support the work of experts ... offers two types of exome sequencing services: 1) Targeted ...
(Date:3/4/2015)... 04, 2015 Research and Markets ... the "Global Biometrics Market Forecast and Opportunities, ... The market for biometric authentication systems is projected ... till 2020 The driving forces for ... needs, government projects and constant development in technology. ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 2PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 3Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3
... Athens, Ga. Most convenience stores have a wide variety ... While shoppers can buy calorie-heavy foods wrapped in pretty packages ... fresh produce, whole grains and low-fat dairy products necessary for ... nearby food source for millions of Americans living in what ...
... Calif.) Magnetic resonance imaging (MRI) on the nanoscale and ... toward the realm of possibility, and a new study co-authored ... extra nudge. The findings appear today in Science ... Ania Bleszynski Jayich, an assistant professor of physics who ...
... in their brain cells a survival secret that might lead ... Illinois at Chicago biologist Thomas Park and colleagues at UIC ... Antonio think the subterranean lifestyle of the pasty-looking rodents may ... when oxygen is scarce. The key may lie in how ...
Cached Biology News:Healthy foods missing from stores in low-income black neighborhoods, UGA study finds 2Healthy foods missing from stores in low-income black neighborhoods, UGA study finds 3Healthy foods missing from stores in low-income black neighborhoods, UGA study finds 4UC Santa Barbara researcher's new study may lead to MRIs on a nanoscale 2Naked mole-rats bear lifesaving clues 2
(Date:3/30/2015)...  NuGene International, Inc. ("NuGene") (OTCQB: NUGN), announced ... has added another internationally recognized researcher to its ... internationally recognized researcher in bio-inspired materials and bio-materials ... University, China , Professor Guan ... North Carolina, Chapel Hill. Following a postdoctoral training ...
(Date:3/30/2015)... GERMANTOWN, Md. , March 30, 2015  /PRNewswire/ ... a leader in synthetic biology, and Merck Serono, ... Germany , today announced an exclusive ... commercialize Chimeric Antigen Receptor T-cell (CAR-T) cancer therapies. ... to develop innovative therapies that modulate the immune ...
(Date:3/30/2015)... -- Richmond Pharmacology nimmt weltweit den ... das erste Zentrum weltweit, das in Zusammenarbeit mit ... London in einer weltweiten ... einem Patienten begonnen hat. Das Therapeutikum wurde für ... einer seltenen Herz- und Nervenkrankheit. ...
(Date:3/29/2015)... Whitehouse, NJ (PRWEB) March 29, 2015 ... strict deadlines often required by our pharmaceutical manufacturing clients, ... renewed its sponsorship of the Berkenstock Race Team for ... track requires not only speed, but a strong sense ... same principles that lead to success in the quality ...
Breaking Biology Technology:UCI Professor Zhibin Guan Joins NuGene Advisory Board 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 3Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 2Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 3Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 4Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2
... CHARLOTTESVILLE, Va., Dec. 21 Diffusion Pharmaceuticals,LLC, ... utilizing a novel mechanism of action that ... its key advisors, Mr. Thomas,Byrne, was recently ... of Amgen,s blockbuster drug Aranesp(R) (darbepoietin alpha), ...
... to serve Pacific Northwest, SEATTLE, Dec. 21 ... the western Washington state congressional delegation has,resulted in ... development,of a state-of-the-art proton-beam therapy center by the ... in the 2008 Omnibus Appropriations,bill signed by President ...
... 21 Abbott (NYSE: ABT ),will present at ... 7, 2008. Thomas C. Freyman, executive vice president, finance ... the company at,11:00 a.m. Central time., A live ... Investor Relations Web site at http://www.abbottinvestor.com . An,archived ...
Cached Biology Technology:Co-Inventor of Amgen's Aranesp(R) Technology Directs Worldwide Patent Strategy for Diffusion Pharmaceuticals' First-in-Class Oxygen Enhancing Therapeutics 2Murray Leads Delegation in Securing $2.1 Million for Proton Therapy Center 2Murray Leads Delegation in Securing $2.1 Million for Proton Therapy Center 3