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Cancer drug aids the regeneration of spinal cord injuries
Date:1/28/2011

After a spinal cord injury a number of factors impede the regeneration of nerve cells. Two of the most important of these factors are the destabilization of the cytoskeleton and the development of scar tissue. While the former prevents regrowth of cells, the latter creates a barrier for severed nerve cells. Scientists of the Max Planck Institute of Neurobiology in Martinsried and their colleagues from the Kennedy Krieger Institute and University of Miami in the United States, and the University of Utrecht in the Netherlands, have now shown that the cancer drug Taxol reduces both regeneration obstacles. (Science, January 27, 2011)

Paraplegia. This is often the long-lasting result, when nerve fibers have been crushed or cut in the spinal cord. In contrast, for example, to the nerves in a cut finger, the injured nerve cells in the central nervous system (CNS) won't regrow. Scientists have been working for decades to discover the reasons for this discrepancy in the regeneration abilities of nerve cells. They have found a variety of factors that prevent the regeneration of CNS nerve cells. One by one a number of substances that act like stop signs and halt the resumption of growth have been discovered. Other obstacles lie within the cells: The microtubules, small protein tubes which compose the cells' cytoskeleton, are completely jumbled in an injured CNS nerve cell. A structured growth becomes impossible. In addition to this, the lost tissue is progressively replaced by scar tissue creating a barrier for growing nerve cells.

Understanding regeneration

Frank Bradke and his team at the Max Planck Institute of Neurobiology in Martinsried study the mechanisms inside CNS nerve cells responsible for stopping their growth: "We try to provoke the cells to ignore the stop signs so that they regrow." For this task, the neurobiologists have focused on studying the role of microtubules. These protein tubes have a parallel arrangeme
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Contact: Stefanie Merker
merker@neuro.mpg.de
49-898-578-3514
Max-Planck-Gesellschaft
Source:Eurekalert  

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