Navigation Links
Cancer-causing gut bacteria exposed
Date:9/21/2008

Normal gut bacteria are thought to be involved in colon cancer but the exact mechanisms have remained unknown. Now, scientists from the USA have discovered that a molecule produced by a common gut bacterium activates signalling pathways that are associated with cancer cells. The research, published in the October issue of the Journal of Medical Microbiology, sheds light on the way gut bacteria can cause colon cancer.

There are more bacteria in our bodies than there ever have been people on the Earth. In fact, there are more bacteria in the colon than there are human cells in our bodies. Most of the bacteria in our guts are harmless and many are beneficial to our health. However, for several decades scientists have thought that some microbes living in the gut may play a role in the formation of sporadic colorectal cancer.

Enterococcus faecalis is a normal gut bacterium. Unlike most gut bacteria, it can survive using two different types of metabolism: respiration and fermentation. When the bacteria use fermentation they release by-products. One of these is a kind of oxygen molecule called superoxide, which can damage DNA and may play a role in the formation of colon tumours.

"We wanted to investigate how colon cells respond to normal gut bacteria that can damage DNA, like E. faecalis," said Professor Mark Huycke from the Department of Veterans Affairs Medical Center in Olklahoma City, USA. "We found that superoxide from E. faecalis led to strong signalling in immune cells called macrophages. It also altered the way some cells in the gut grew and divided and even increased the productivity of genes that are associated with cancer."

The team found that 42 genes in epithelial cells in the gut are involved in the regulation of the cell cycle, cell death and signalling based on the unique metabolism of E. faecalis. This suggests that cells of the lining of the colon are rapidly affected when E. faecalis switches to fermentation. It also indicates that E. faecalis may have developed novel mechanisms to encourage colon cells to turn cancerous.

Intestinal cancers occur almost exclusively in the colon where billions of bacteria are in contact with the gut surface. For years scientists have tried to identify links between gut bacteria and people who are at risk of colon cancer. This has been made difficult by the enormous complexity of the microbial communities in the intestine.

"Our findings are among the first to explore mechanisms by which normal gut bacteria damage DNA and alter gene regulation in the colon that might lead to cancer," said Professor Huycke. "This research puts n to perspective the complexity of the effects normal gut bacteria can have on the health of an individual."


'/>"/>

Contact: Lucy Goodchild
l.goodchild@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Rare cancer-causing syndrome found, for the first time, in Singapore
2. Researchers identify cancer-causing gene in many colon cancers
3. Shuttle brings space-grown strep bacteria back for study
4. The worlds oldest bacteria
5. Bacteria from sponges make new pharmaceuticals
6. Boston University biomedical engineers find chink in bacterias armor
7. University of Leicester scientists discover technique to help friendly bacteria
8. Spaceflight shown to alter ability of bacteria to cause disease
9. A tiny pinch from a z-ring helps bacteria cells divide
10. Legionnaires bacterial proteins work together to survive
11. Scripps research team blocks bacterial communication system to prevent deadly staph infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") announces ... Clean Technology Fund I, LP and Clean Technology Fund ... venture capital funds which together hold approximately 59% of ... as converted basis), that they have entered into an ... in Biorem to TUS Holdings Co. Ltd. ("TUS") (en.tusholdings.com) ...
(Date:6/27/2016)... N.C. (PRWEB) , ... June 27, 2016 , ... ... commercial operations for Amgen, will join the faculty of the University of ... as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: