Navigation Links
Cancer-causing bacterium targets tumor-suppressor protein
Date:8/2/2010

tes different kinds of genes controlling cell growth and death," Chen said. "The first thing we wanted to see was whether H. pylori has any effect on the transcription activity of RUNX3."

Two graduate students in Chen's lab, Ying-Hung Nicole Tsang and Acacia Lamb, began the study by examining RUNX3 transcription activity in H. pylori-infected gastric epithelial cells. They found that infection with CagA-positive H. pylori inhibited the transcription activity of RUNX3 and reduced levels of the RUNX3 protein in cells. CagA-negative H. pylori had no effect on RUNX3 levels or activity.

"In fact, CagA alone is sufficient to down-regulate the RUNX3 transcription activity and reduce the expression of RUNX3, further supporting the importance of this bacterial protein in the genesis of gastric disease," Chen said.

Further tests revealed that CagA and RUNX3 physically interact with each other in human epithelial cells. The researchers found that a newly identified domain within CagA, the WW domain, recognizes a sequence in the RUNX3 protein known as the "PY motif." They further showed that this interaction leads to the "tagging" of RUNX3 for degradation via a process called ubiquitination.

Previous studies found that there are several unique sequences within the carboxyl-terminal region of CagA that are vital to the protein's ability to interact with host proteins and disrupt normal cellular processes.

"This is the first time anybody has identified a unique domain within the amino-terminal region of the CagA protein, and it will help us to better understand how this oncogenic protein functions," Chen said. "This study has uncovered a new step in the initiation of H. pylori-induced gastric cancer."

The accumulation of many deleterious changes in cells leads to the development of cancer. RUNX3 helps cells react when cellular processes go awry, so H. pylori-induced degradation of
'/>"/>

Contact: Diana Yates, Life Sciences Editor
diya@illinois.edu
217-333-5802
University of Illinois at Urbana-Champaign
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Cancer-causing gene discovery suggests new therapies
2. Link between unexploded munitions in oceans and cancer-causing toxins determined
3. Cancer-causing protein can also help fight the tumors it causes
4. IU researchers target vascular disease linked to cancer-causing gene mutation
5. TB bacterium uses its sugar coat to sweeten its chances of living in lungs
6. Scientists sequence genome of the N2-fixing, soil-living bacterium Azotobacter vinelandii
7. UTSA biology researchers demystify elusive war zone bacterium
8. Bacterium helps formation of gold
9. Brand new species of bacterium found in the Gullmarsfjord north of Gothenburg
10. Student research team sequences genome of bacterium discovered in Virginia Tech garden
11. Overcoming anthrax bacteriums natural defenses could hold key to new treatments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-causing bacterium targets tumor-suppressor protein
(Date:12/10/2014)...     Jifflenow ...   Jifflenow, a leading provider ... business-to-business (B2B) events, today announced a partnership with ... communication (NFC), Bluetooth low energy (BLE), and cloud-based ... Jifflenow will integrate its meeting scheduling ...
(Date:12/3/2014)... Dec. 2, 2014   Marvin Test Solutions ... test solutions for military, aerospace, and manufacturing organizations, ... its successful TS-900 PXI semiconductor test platform ... of high-end systems to customers at a fraction ... to traditional ATE. "Our semiconductor ...
(Date:11/21/2014)... MOUNTAIN VIEW, Calif. , Nov. 20, 2014 /PRNewswire/ ... for higher driver efficiency are piloting the North American ... the number of accidents growing, gesture recognition systems that ... will make a mark in the industry. ... of the Automotive Gesture Recognition Market in ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... International Human Frontier Science Program Organization (HFSPO) is pleased ... international postdoctoral fellowships for 2013 following a rigorous selection ... applications were received in this round from applicants originating ... given to young scientists within 3 years of the ...
... detailed study, Tecnalia has calculated the carbon footprint of the ... the field work right up to the end of the ... piece of information that allows one to know the quantity ... enabled the Grupo Faustino to be the first winery to ...
... CA----Ever find yourself racking your brain on a Monday morning ... you do find those keys, you can thank the hippocampus, ... different environments-such as that room where your keys were hiding ... Salk Institute for Biological Studies have helped explain how the ...
Cached Biology News:The 2013 HFSP postdoctoral fellowship awards 2Tecnalia has calculated the carbon footprint of some wines 2The neuroscience of finding your lost keys 2The neuroscience of finding your lost keys 3
(Date:12/22/2014)... , Dec. 22, 2014  ( www.competitivehealth.com ) ... an online medical bill review and advocacy service, has ... the FREE WellCard Savings discount health services marketplace. ... that was more than they expected to pay. As ... health care costs, WellCard Savings is pleased to offer ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a new ... network of more than 20 contributing fertility practices ... access to a national pool of frozen donor ... of Memphis is the only fertility clinic in the ... Dr. William Kutteh , director of Fertility Associates of ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the nation’s ... Pharm.D. to the newly created position of Vice President ... Dr. Maroulis will continue to manage the entire specialty ... pharmacies as the company expands. Dr. Maroulis has been ... has served in many different capacities in the pharmacy, ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. ... announced today that they have been acquired by Roche ... is a privately held company that provides a big ... generation sequencing (NGS) data for the academic and translational ... Sequencing Unit, and will continue to focus on development ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... ,, The first precast gels for automated sequencing ... Jensen Harry Osterman Mark,Vanek ,LI-COR Biotechnology Division ... precast,gels for automated DNA sequencing and genetic analysis. Stratagenes ... provided polymerized and are,ready to load in less than ...
... Gold cells reduce the time and effort needed for,transformationswithout ... Amy Duncan Bruce,Jerpseth Alan Greener ,Stratagene , ... , strain* in an easy-to-use, single-reaction format that,yield ... transformants/g of,supercoiled DNA or the competent efficiency of ...
... pathways , , Li Xu Tim ... Enhancer elements are the convergent points for many ... assessment of the in,vivo activation of these pathways, ... signal transduction pathway cis-reporting systems. Each of the ...
Cached Biology Technology:CastAway Precast Gels for Rapid Automated DNA Sequence Analysis 2CastAway Precast Gels for Rapid Automated DNA Sequence Analysis 3CastAway Precast Gels for Rapid Automated DNA Sequence Analysis 4CastAway Precast Gels for Rapid Automated DNA Sequence Analysis 5XL10-Gold Cells Supplied in New Single-Reaction Format 2XL10-Gold Cells Supplied in New Single-Reaction Format 3XL10-Gold Cells Supplied in New Single-Reaction Format 4Signal Transduction Reporting Systems Using Cis-Acting Enhancer,Elements 2Signal Transduction Reporting Systems Using Cis-Acting Enhancer,Elements 3Signal Transduction Reporting Systems Using Cis-Acting Enhancer,Elements 4
...
... gun system, 220-240 V, is used for ... This handheld device employs an adjustable helium ... biomaterial-coated gold microcarriers from the inner wall ... target cells. This system has a 2 ...
Mouse monoclonal antibody raised against a full length recombinant YARS. NCBI Entrez Gene ID = YARS...
Mouse monoclonal antibody raised against a partial recombinant NR4A2. NCBI Entrez Gene ID = NR4A2...
Biology Products: