Navigation Links
Cancer breakthrough to prevent heart failure and increase survival rates
Date:2/9/2011

A breakthrough by scientists at Queen's University Belfast could help reduce heart failure in cancer patients around the world, and ultimately increase survival rates.

Scientists at Queen's Centre for Vision and Vascular Science have discovered the role of an enzyme which, when a patient receives chemotherapy, can cause life-threatening damage to the heart. This has, until now, restricted the amount of chemotherapy doses a patient can receive; but while protecting the heart, this dilutes the chemotherapy's effectiveness in destroying cancerous tumours.

By identifying the role of the enzyme - NADPH oxidase - work can now go ahead into making chemotherapy treatments more effective and reduce the toxic effects of cancer treatment on the heart.

Dr David Grieve, jointly leading on the research at Queen's School of Medicine, Dentistry and Biomedical Sciences said: "While chemotherapy drugs are highly effective in treating a wide range of tumours, they can also cause irreversible damage to the heart. This means that doctors are restricted in the doses they can administer to patients. In recent years, scientists have been searching for new drugs to prevent these side-effects.

"Although we have known about the NADPH oxidase enzyme for many years, until now, we were not aware of its crucial role in causing heart damage associated with chemotherapy. Our research findings hold clear potential for the creation of new drugs to block the action of the enzyme, which could significantly reduce heart damage in cancer patients.

"Ultimately, this could allow for the safer use of higher doses of chemotherapy drugs and make the treatment more effective against tumours. Despite improved treatments, cancer is currently responsible for 25 per cent of all mortality in the western world. By reducing the risk of heart failure associated with chemotherapy, patient survival rates could be significantly increased."

Scientists at Queen's are now concentrating their efforts on further studies to define the precise role of NADPH oxidase in the development of heart failure associated with cancer therapies. It is hoped that these may lead to the development of a drug which would have the potential to save lives among cancer patients.


'/>"/>

Contact: Anne-Marie Clarke
anne-marie.clarke@qub.ac.uk
44-028-909-75320
Queen's University Belfast
Source:Eurekalert

Related biology news :

1. Photodynamic therapy against cancer
2. Sweeping view of prostate cancer genome yields deep insights
3. Research team honored for innovative science to advance cancer research
4. Blood-clotting protein linked to cancer and septicemia
5. Discovery may lead to turning back the clock on ovarian cancer
6. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
7. Early tests find nanoshell therapy effective against brain cancer
8. Scientists synthesize long-sought-after anticancer agent
9. Cornell Dots that light up cancer cells go into clinical trials
10. Antibiotic offers potential for anti-cancer activity
11. Cancer drug aids the regeneration of spinal cord injuries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/17/2016)... announces that it has just released a new white paper authored by Zettar that ... speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system can be a ...
(Date:11/15/2016)... Nov 15, 2016 Research and Markets has ... to 2021" report to their offering. ... ... Billion by 2021 from USD 6.21 Billion in 2016, growing at ... Growth of the bioinformatics market is driven by the growing demand ...
(Date:6/27/2016)... Research and Markets has announced the addition of the ... The report forecasts the biometrics ... a CAGR of 12.28% during the period 2016-2020. ... with inputs from industry experts. The report covers the market landscape ... includes a discussion of the key vendors operating in this market. ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... DrugDev believes ... standardization and a beautiful technology experience. All three tenets were on display at the ... trial leaders from over 40 sponsor, CRO and site organizations to discuss innovation and ...
(Date:12/2/2016)... The immunohistochemistry (IHC) market is projected to reach ... during the forecast period of 2016 to 2021 dominated by immunohistochemistry ... the largest share of immunohistochemistry (IHC) market, by end user.   ... , , ... across 225 pages, profiling 10 companies and supported with 181 tables ...
(Date:11/30/2016)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company") ... to announce the formation of EyGen, Ltd. a ... assets through proof of concept. EyGen,s lead asset ... Pharmaceuticals Limited and being developed for topical ophthalmic ... segment diseases. This agent has the potential to ...
(Date:11/30/2016)... and BEIJING , Nov. 30, ... commercial provider of genomic services and solutions with cutting ... that it has completed a USD $75 Million [515 ... Co., Ltd.,s CMB International Capital Management ( Shenzhen ... Management Co., Ltd. ("SDIC Innovation") and Shanghai Sigma Square ...
Breaking Biology Technology: