Navigation Links
Cancer biomarker -- detectable by blood test -- could improve prostate cancer detection
Date:8/8/2011

CINCINNATIA new study supports the use of a DNA-based "biomarker" blood test as a complement to the prostate-specific antigen (PSA) test currently offered to screen men for prostate cancer. University of Cincinnati (UC) researchers report their findings online ahead of print in the British Journal of Cancer.

Researchers conducted a meta-analysis of existing published data related to DNA methylation in bodily fluids. The goal was to evaluate a specific cancer biomarkerknown as GSTP1as a screening tool for prostate cancer.

The study was a cross-disciplinary collaborative effort of UC molecular epidemiologist Tianying Wu, MD, PhD, epigenetic expert and UC environmental health chair Shuk-Mei Ho, PhD, former UC environmental health post-doc Wang-Yee Tang, PhD, UC statistician Jeff Welge and Harvard cancer epidemiologist Edward Giovannucci, MD. Wu's postdoctoral fellow Palash Mallick, PhD, also contributed to the study.

Wu merged epidemiologic and molecular data from 22 studies conducted in the United States and Europe between 2000 and 2009. More than 2000 human biologic samples (1,635 prostate cancer cases and 573 controls) were analyzed for the current study, including whole blood, plasma, urine, ejaculates and other secretions.

Wu determined that GSTP1 was a statistically significant biomarker for prostate cancer and could increase the specificity of prostate cancer diagnosis by up to 70 percent as compared to using the PSA test alone.

"The PSA test is highly sensitive, but it cannot differentiate between prostate cancer and benign prostatic conditions such as benign prostatic hyperplasia, leading many men to have unnecessary biopsies," says Wu, lead author of the study and assistant professor of environmental health at UC.

"It is unlikely that we would find a marker that has the same sensitivity as PSA," she adds, "but finding a highly specific circulating biomarker like GSTP1 that complements
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breast cancer treatment resistance linked to signaling pathway
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. The dietary supplement genistein can undermine breast cancer treatment
4. Saliva proteins could help detection of oral cancer
5. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
6. Breakthrough optical technology to assess colon cancer risk, accuracy
7. Breast cancer cells recycle to escape death by hormonal therapy
8. Nanodiamond drug device could transform cancer treatment
9. Second lumpectomy for breast cancer reduces survival rates
10. Study looks at psychological impact of gene test for breast cancer
11. SNM releases new fact sheet on breast cancer and molecular imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on ... Pereira was interviewed on July 1 st on ... . Mr. Pereira discusses the company,s next generation smart ... how the Wocket™ aims to replace a traditional wallet with ... Harris tells Gino he has never heard of the ...
(Date:7/10/2014)... Sweden , July 8, 2014 ... has won a new design win (DW). An Asian OEM ... date for mass production start in August 2014.   ... Asian smartphone OEM, which has a planned date for start ... an initial ramp order of SEK 5M, for delivery in ...
(Date:7/10/2014)... An international team ... step of photosynthesis in action for the first time. The ... used the world,s most powerful X-ray flashlight at the US ... molecular complex called photosystem II as it splits water into ... earth,s atmosphere. The researchers report their results in the scientific ...
Breaking Biology News(10 mins):Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Scientists watch photosynthesis in action 2Scientists watch photosynthesis in action 3
... Calif.) The National Institutes of Health (NIH) has ... chemistry, and biology researchers to develop a highly efficient ... technology provides an entirely new method of discovering and ... of applications, including next-generation disease diagnosis at the point ...
... ongoing destruction of specific neurons within the brain. It affects ... to involuntary movement and loss of muscle co-ordination. New ... Neurodegeneration shows that the RyanR inhibitor Dantrolene is able ... a mouse model of HD. Progressive damage to ...
... the final weeks before delivery is tough for any pregnant ... extreme physical changes that accompany the later stages of pregnancy. ... gait change such as a change in stride length ... Intrigued by the ways that newborn dolphins learn to swim ...
Cached Biology News:Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology 2Researchers awarded $3.2 million from NIH to pioneer advanced biomolecule discovery technology 3Pregnancy is a drag for bottlenose dolphins 2
(Date:7/10/2014)... can sit upside down forever. Nanophysics makes sure of that. ... article just published in Physical Review E . Knowledge ... spiders that seem to be able to sit still forever, ... many years. We will soon be able to buy smart ... foot. But the fact is, sooner or later the grip ...
(Date:7/10/2014)... the University of Illinois at Urbana-Champaign provides new ... of spin and heat at the nanoscale, and ... for data storage and information processing. , ... momentum. In a typical charge current, electrons, spin-angular-momentum ... explained David Cahill, a professor of materials science ...
(Date:1/15/2014)... an approach akin to assembling a club sandwich ... Technology (NIST) researchers have succeeded in crafting a ... flammability of foam commonly used in upholstered furniture ... the nanotube-coated polyurethane foam was reduced 35 percent ...
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
Breaking Biology Technology:Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... 8, 2011 Quest Diagnostics joined the American Cancer ... the American Cancer Society,s historic Cancer Prevention Study - ... longitudinal study is between November 8 and 19, 2011. ... and genetic factors that influence cancer risk by following ...
... 2011 Accuray Incorporated (Nasdaq: ARAY), the ... results for the first quarter of fiscal 2012 that ... 2011, Accuray completed the acquisition of TomoTherapy. As a ... consolidation of both Accuray and TomoTherapy.  Non-GAAP results are ...
... YORK, Nov. 8, 2011 Reportlinker.com announces ... available in its catalogue: ... Suppliers http://www.reportlinker.com/p0681961/Genomic-Technologies-Market-Insights-for-Life-Science-Suppliers.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics ... Genomic Technologies: Market Insights for Life Science ...
Cached Biology Technology:Quest Diagnostics Encourages Denver Area Residents to Enroll in Historic American Cancer Society Prevention Study November 8th - 19th 2Quest Diagnostics Encourages Denver Area Residents to Enroll in Historic American Cancer Society Prevention Study November 8th - 19th 3Accuray Announces Results for First Quarter Fiscal 2012 2Accuray Announces Results for First Quarter Fiscal 2012 3Accuray Announces Results for First Quarter Fiscal 2012 4Accuray Announces Results for First Quarter Fiscal 2012 5Accuray Announces Results for First Quarter Fiscal 2012 6Accuray Announces Results for First Quarter Fiscal 2012 7Accuray Announces Results for First Quarter Fiscal 2012 8Accuray Announces Results for First Quarter Fiscal 2012 9Accuray Announces Results for First Quarter Fiscal 2012 10Accuray Announces Results for First Quarter Fiscal 2012 11Genomic Technologies: Market Insights for Life Science Suppliers 2Genomic Technologies: Market Insights for Life Science Suppliers 3
Rad51, N-terminal...
DDO Immunogen: DDO (NP_003640, 270 a.a. ~ 370 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
... Immobilized] Goat Immunogen: Goats ... (MASMTGGQQMG). Antibody was isolated by affinity ... support. Goat anti- human T7 affinity purified ... cyanogens bromide method. Specificity: ...
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Biology Products: