Navigation Links
Cancer and arthritis therapy may be promising treatment for diabetes
Date:12/18/2007

New Haven, Conn.An antibody used to treat certain cancers and rheumatoid arthritis appears to greatly delay type 1 diabetes in mice, Yale School of Medicine researchers report in the Journal of Clinical Investigation.

Even better, the beneficial effects of the antibody continue to be observed long after the antibody is no longer administered, the researchers said.

The antibody, rituximab (anti-CD20), depletes B cells. Experimental evidence in mutant mice indicates that B cells play a role in autoimmune diseases by interacting with T cells of the immune system. It is T cells that destroy insulin-producing cells directly in the pancreas, leading to type 1 diabetes.

Our paper shows, for the first time, that after successful B cell depletion, regulatory cells emerge that can continue to suppress the inflammatory and autoimmune response even after the B cells return, said Li Wen, senior research scientist in the division of endocrinology. Even more strikingly, we found that these regulatory cells include both B and T cells.

To determine if B cell depletion would work as a therapy for type 1 diabetes, Wen and her colleague at Yale, Mark Shlomchik, M.D., professor of laboratory medicine and immunobiology, developed a mouse model. They engineered mice that were predisposed to diabetes and had the human version of CD20, the molecule rituximab targets, on the surface of their B cells.

The researchers tested a mouse version of the drug to deplete B cells in mice either before diabetes onset, or within days of diagnosis with diabetes. The drug treatment significantly delayed diabetes onset in pre-diabetic mice. This translated to a 10- to 15-week delay in developing diabetes compared to mice given a sham treatment. The equivalent period for humans would be approximately 10 to 15 years. Of the 14 mice that already had diabetes, five stopped needing insulin for two to five months while all the sham-treated mice remained dia
'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. Protein chatter linked to cancer activation
5. Newly created cancer stem cells could aid breast cancer research
6. Western diet linked to increased risk of colon cancer recurrence
7. Obesity and lack of exercise could enhance the risk of pancreatic cancer
8. Low levels of key protein may indicate pancreatic cancer risk
9. Birth records hold pancreatic cancer clue
10. Many parents at-risk for cancer disclose genetic test results to children
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Coral Gables, Fla. (April 21, 2014) -- There are ... out their feathers and spread their colorful tails; satin ... them with blue and shiny objects; and European bitterling ... Each species has evolved a unique method to communicate ... "Signaling can have profound fitness ...
(Date:4/22/2014)... FL, April 22, 2014 Scientists from the Florida ... a protein complex that plays a critical but previously ... The study, which showed a novel role for a ... in the journal eLife , a publisher supported ... Society and the Wellcome Trust. , "This is a ...
(Date:4/22/2014)... Ltd.,s nanotechnology expert will present a poster ... the 7th International Nanotoxicology Congress to be ... Dr. Monita Sharma will outline a strategy consistent with ... Sciences, " Toxicity Testing in the 21st Century: A ... non-animal methods involving human cells and cell lines for ...
Breaking Biology News(10 mins):Best practices in communication for the animal world 2Best practices in communication for the animal world 3Scientists identify critical new protein complex involved in learning and memory 2
... jerks its head uncontrollably for no apparent reason. There ... people, most notably trigeminal neuralgia, and headshaking in horses. ... and treating the condition in horses, the pathology of ... A recent study led by academics ...
... PARSIPPANY, NJ (November 14, 2012) Parents may have some ... study, funded by Pinnacle Foods, Birds Eye brand and published ... to the plate led to more positive evaluations of both ... vegetables with dinner, participants believed the main course would taste ...
... lung cancer research team reports that lung cancer stem ... offering a new avenue for investigating immunotherapy treatment options ... Morris, MD, and his colleagues report their findings in ... , a peer-reviewed online publication that features original research ...
Cached Biology News:Study investigates headshaking in horses 2New study reveals more inspiring reasons to serve veggies at dinner 2Stem cell finding could advance immunotherapy for lung cancer 2
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an ... products to serve the wound care market. , Free ... Alliqua was restructured with a seasoned management team and ...
(Date:1/14/2014)... In recent years, growing suspicion about ... product development and promotion has led to unprecedented levels ... by concerns about the insidious impact of commercialization of ... fines to the world’s biggest pharmas for illegal marketing ...
(Date:1/14/2014)... 13, 2014 Bob Hainsey, a semiconductor ... 20 years in the industry, has joined SPIE, ... will serve as the society’s Science and Technology Strategist. ... SPIE as our Technology Strategist, further strengthening the technical ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... Twelve-Week Maintenance DosingBEERSE, Belgium, Jan. 22 ... a new class of biologics, has been approved by ... approved indication of ustekinumab is for the treatment of ... to respond to, or who have a contraindication to, ...
... Cell Innovations, Inc., (SCLL.PK) announced today that it has filed a new ... cells. , ... Houston, TX (PRWEB) January 22, 2009 -- Stem Cell ... application for the production of pluripotent stem cells from primordial germ cells. ...
... for testing the quality of a sperm before it ... conception. , Researchers at the University of Edinburgh, funded ... have created a way of chemically ,fingerprinting, individual sperm ... consider whether the sperm is healthy enough to be ...
Cached Biology Technology:New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis 2New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis 3New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis 4Stem Cell Innovations, Inc., Files New Patent Application 2Stem Cell Innovations, Inc., Files New Patent Application 3New sperm shaker to improve IVF success 2
... Microplate Handler is a high-capacity, plug-and-play ... BioTeks washers, readers and liquid handling ... ultimate flexibility and intuitive and powerful ... to single devices or linking several ...
XPLAC (S-17)...
Request Info...
ZBP-89 (S-15)...
Biology Products: