Navigation Links
Cancer: The cost of being smarter than chimps?

Are the cognitively superior brains of humans, in part, responsible for our higher rates of cancer? That's a question that has nagged at John McDonald, chair of Georgia Tech's School of Biology and chief research scientist at the Ovarian Cancer Institute, for a while. Now, after an initial study, it seems that McDonald is on to something. The new study is available online in the journal Medical Hypothesis and will appear in the forthcoming issue of the journal.

"I was always intrigued by the fact that chimpanzees appear to have lower rates of cancer than humans," said McDonald. "So we went back and reanalyzed some previously reported gene expression studies including data that were not used in the original analyses."

McDonald and his graduate students, Gaurav Arora and Nalini Polivarapu, compared chimp-human gene expression patterns in five tissues: brain, testes, liver, kidneys and heart. They found distinct differences in the way apoptosis or programmed cell death operates, suggesting that humans do not "self-destroy" cells as effectively as chimpanzees do. Apoptosis is one of the primary mechanisms by which our bodies destroy cancer cells.

"The results from our analysis suggest that humans aren't as efficient as chimpanzees in carrying out programmed cell death. We believe this difference may have evolved as a way to increase brain size and associated cognitive ability in humans, but the cost could be an increased propensity for cancer," said McDonald.

Like all evolutionary hypotheses, this can't be proven absolutely, according to McDonald. However, his lab has recently obtained additional direct experimental evidence consistent with the hypothesis that apoptotic function is more efficient in chimps than in humans.


Contact: David Terraso
Georgia Institute of Technology

Page: 1

Related biology news :

1. From cars to cancer: UH professor employs auto industry tools for tumor therapy
2. Early detection of lung cancer: New data presented at multidisciplinary meeting
3. Cancer: Another step towards medication
4. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
5. Hispanic women and breast cancer: An understudied group
6. Stem cells and cancer: cancer pathways that also control the adult stem cell population
7. Scientists discover how cigarette smoke causes cancer: Study points to new treatments, safer tobacco
8. Prostate cancer: Watchful wait or vaccinate?
9. DNA-Prokids: Genetic identification against traffic in human beings
10. The importance of being helpful -- Cooperative cichlids boost their own reproductive success
11. Promising new drug being evaluated as possible treatment option for fragile X syndrome
Post Your Comments:
Related Image:
Cancer: The cost of being smarter than chimps?
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/9/2016)...  Perkotek an innovation leader in attendance control systems is proud to announce the ... employers to make sure the right employees are actually signing in, and to even ... ... ... ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, ... after being treated for breast cancer benefitted from an injection of stem cells derived ... debilitating, frequent side effect of cancer treatment. , Lymphedema refers to the ...
Breaking Biology Technology: