Navigation Links
Cancer: 'Primitive' gene discovered
Date:2/11/2010

To find the causes for cancer, biochemists and developmental biologists at the University of Innsbruck, Austria, retraced the function of an important human cancer gene 600 million years back in time. For the first time, they have identified the oncogene myc in a fresh water polyp and they have shown that this oncogene has similar biochemical functions in ancestral metazoan and in humans. The scientists published their findings in PNAS.

The myc gene plays an important role in the growth of organisms. It produces a protein that acts as a gene regulator, which controls the expression of up to 15 % of all human genes. This means that it controls whether these genes are activated or deactivated. A deregulation of the myc gene leads to uncontrolled cell proliferation and to cancer; a deregulated myc gene occurs in about 30 % of all human cancers. "To get a better understanding of the deregulation process caused by the oncogene, we would have to know which genes are regulated by myc and which of these are important for cancers", says Klaus Bister from the Institute of Biochemistry at the University of Innsbruck. Due to the complexity of the human organism, researchers use simpler model systems for their experiments, whose results may then be translated to humans. The Innsbruck scientific teams of Klaus Bister, Markus Hartl and Bert Hobmayer have, for the first time, identified the oncogene in a fresh water polyp (Hydra) and they have shown that it has very similar functions when compared with humans.

Oncogene found in stem cells The two millimeter long Hydra were one of the first metazoans that developed on the earth about 600 million years ago and can still be found in many waters. "It is amazing that we have been able to find this oncogene in such a simple organism", says Hydra expert Hobmayer from the Institute of Zoology. "Because the gene has been conserved in evolution all the way from Hydra to humans, we are now able to a
'/>"/>

Contact: Klaus Bister
klaus.bister@uibk.ac.at
43-512-507-5270
University of Innsbruck
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cancer: The cost of being smarter than chimps?
2. From cars to cancer: UH professor employs auto industry tools for tumor therapy
3. Early detection of lung cancer: New data presented at multidisciplinary meeting
4. Cancer: Another step towards medication
5. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
6. Hispanic women and breast cancer: An understudied group
7. Stem cells and cancer: cancer pathways that also control the adult stem cell population
8. Scientists discover how cigarette smoke causes cancer: Study points to new treatments, safer tobacco
9. Prostate cancer: Watchful wait or vaccinate?
10. Primitive early relative of armadillos helps rewrite evolutionary family tree
11. How did chemical constituents essential to life arise on primitive Earth?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer: 'Primitive' gene discovered
(Date:12/3/2014)... 2, 2014   Marvin Test Solutions , ... solutions for military, aerospace, and manufacturing organizations, today ... successful TS-900 PXI semiconductor test platform . ... high-end systems to customers at a fraction of ... traditional ATE. "Our semiconductor customers ...
(Date:11/21/2014)... -- According to a new market research ... Access Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), ... Geography - Global Forecasts to 2020", published by MarketsandMarkets, ... around $25 Billion in 2014 and is expected to ... of 8.69%. Browse 116 market data Tables ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws ... efficiency are piloting the North American and European automotive ... accidents growing, gesture recognition systems that are intuitive and ... mark in the industry. New analysis ... Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... air since the Industrial Revolution appears to have changed ... new analysis published this week in Nature . ... in rivers, estuaries and continental shelves suggests that collectively ... than it releases. The shift could impact global models ...
... data centers are actually more energy efficient than ... Traditionally, computers have been cooled down with mechanical ... maintenance systems associated with servers also require electricity. ... this extra electricity negatively impacts the data centers, ...
... years, cultivated silkworms have been spinning luxurious white silk ... current dyeing practices produce wastewater that contains potentially harmful ... dyeing method in which they coax already-colored fibers from ... are published in the journal ACS Sustainable Chemistry ...
Cached Biology News:Coastal sea change 2Coastal sea change 3Data centers can be cooled down in environmentally friendly, energy efficient ways 2
(Date:12/19/2014)... Dec. 18, 2014 Relmada Therapeutics, Inc. (OTCQB: ... treatment of chronic pain, announced the results of its ... "This was a transformational year in Relmada,s history and ... our company," said Sergio Traversa , chief executive ... executed on key financial, human resource and clinical development ...
(Date:12/17/2014)... 17, 2014 Ipsen Biopharmaceuticals, Inc., ... ADR: IPSEY), today announced that Somatuline® ... Somatuline®) was approved by the U.S. Food and ... neuroendocrine tumors (GEP-NETs) in adult patients with unresectable, ... disease to improve progression-free survival (PFS). , “The ...
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 Audacity, ... activation agency and member of the Huntsworth Health Group, ... to its executive team. In her role, Gonzales will ... , “We are incredibly honored to welcome a talent ... Chief and CEO, Gaëtan Fraikin. “She is a proven ...
(Date:12/17/2014)... Mass. , Dec. 17, 2014   Synageva ... biopharmaceutical company developing therapeutic products for rare disorders, announced ... Conference being held in San Francisco, CA. ... President and Chief Executive Officer, will present on Monday, ... EST).  The presentation will be webcast live and may ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2
... Jan. 25, 2011 Reportlinker.com announces ... is available in its catalogue: ... Chemistry and Immunodiagnostics Markets: US, Europe, ... Expansion Strategies for Instrumentand Reagent Suppliers ...
... Reportlinker.com announces that a new market research report ... Technologies and Global Markets http://www.reportlinker.com/p096550/Vaccine-Technologies-and-Global-Markets.html ... animal vaccines reached approximately $25.2 billion in 2009.  The ... growth rate (CAGR) of 17.9% to reach $64.2 billion ...
... An interdisciplinary team from Columbia University that includes ... from the University,s departments of Physics and Chemistry, has ... very short time scales using nanoscale transistors. In a ... Nature Nanotechnology , they show how, for the first ...
Cached Biology Technology:Reportlinker Adds The 2011 Clinical Chemistry and Immunodiagnostics Markets: US, Europe, Japan Product Development Opportunities and Business Expansion Strategies for Instrumentand Reagent Suppliers 2Reportlinker Adds Vaccine Technologies and Global Markets 2Reportlinker Adds Vaccine Technologies and Global Markets 3Reportlinker Adds Vaccine Technologies and Global Markets 4Reportlinker Adds Vaccine Technologies and Global Markets 5Columbia University researchers use nanoscale transistors to study single-molecule interactions 2
...
Packaging: 6 bottles for 1 l ready-to-use-solution ID clarifier: ready-to-use solution ...
... of a class of proteins who function to ... S plays an integral role in proofreading the ... excision repair and in preventing chromosomal recombination between ... DNA specifically at base pair mismatches and small ...
TGase3 (S-20)...
Biology Products: