Navigation Links
Cancer: 'Primitive' gene discovered
Date:2/11/2010

To find the causes for cancer, biochemists and developmental biologists at the University of Innsbruck, Austria, retraced the function of an important human cancer gene 600 million years back in time. For the first time, they have identified the oncogene myc in a fresh water polyp and they have shown that this oncogene has similar biochemical functions in ancestral metazoan and in humans. The scientists published their findings in PNAS.

The myc gene plays an important role in the growth of organisms. It produces a protein that acts as a gene regulator, which controls the expression of up to 15 % of all human genes. This means that it controls whether these genes are activated or deactivated. A deregulation of the myc gene leads to uncontrolled cell proliferation and to cancer; a deregulated myc gene occurs in about 30 % of all human cancers. "To get a better understanding of the deregulation process caused by the oncogene, we would have to know which genes are regulated by myc and which of these are important for cancers", says Klaus Bister from the Institute of Biochemistry at the University of Innsbruck. Due to the complexity of the human organism, researchers use simpler model systems for their experiments, whose results may then be translated to humans. The Innsbruck scientific teams of Klaus Bister, Markus Hartl and Bert Hobmayer have, for the first time, identified the oncogene in a fresh water polyp (Hydra) and they have shown that it has very similar functions when compared with humans.

Oncogene found in stem cells The two millimeter long Hydra were one of the first metazoans that developed on the earth about 600 million years ago and can still be found in many waters. "It is amazing that we have been able to find this oncogene in such a simple organism", says Hydra expert Hobmayer from the Institute of Zoology. "Because the gene has been conserved in evolution all the way from Hydra to humans, we are now able to a
'/>"/>

Contact: Klaus Bister
klaus.bister@uibk.ac.at
43-512-507-5270
University of Innsbruck
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cancer: The cost of being smarter than chimps?
2. From cars to cancer: UH professor employs auto industry tools for tumor therapy
3. Early detection of lung cancer: New data presented at multidisciplinary meeting
4. Cancer: Another step towards medication
5. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
6. Hispanic women and breast cancer: An understudied group
7. Stem cells and cancer: cancer pathways that also control the adult stem cell population
8. Scientists discover how cigarette smoke causes cancer: Study points to new treatments, safer tobacco
9. Prostate cancer: Watchful wait or vaccinate?
10. Primitive early relative of armadillos helps rewrite evolutionary family tree
11. How did chemical constituents essential to life arise on primitive Earth?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer: 'Primitive' gene discovered
(Date:7/25/2014)... WASHINGTON (July 24, 2014)The link between autism and ... the puzzle of the disease, and is largely ... Foundation Autism Research Initiative (SFARI), George Washington University ... to offer truly integrative and in-depth answers to ... research. , LaMantia, professor of pharmacology and ...
(Date:7/25/2014)... Prediabetes and Diabetes increasingly consume the healthcare ... immediate attention. , To address the ... impacting low-and middle-income countries, global leaders in ... research in diabetes prevention and development of ... important text. , This book on ...
(Date:7/25/2014)... After development of diffusion tensor tractography (DTT), which ... reconstruction and estimation for three motor tracts, such ... the corticoreticular pathway became possible. The corticospinal tract ... for motor function in the human brain. Several ... tract by transtentorial herniation. In addition, some studies ...
Breaking Biology News(10 mins):GW researcher receives grant to answer the how and why of autism during development 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... and lizards likely gave birth to live young, rather than ... forth in their preferred reproductive mode, according to research published ... "This is a very unusual and controversial finding, and a ... Pyron, Robert F. Griggs Assistant Professor of Biology in the ...
... of millions of Americans, there,s no such thing as the ... hear a constant ringing, buzzing, hissing, humming or other noise ... be debilitating and life-altering. Now, University of Michigan ... what is going on inside their unquiet brains. The ...
... research indicates that for loggerhead sea turtles in the Northwest ... and favorable climate conditions in the year or two prior ... of nests produced by these animals in a given year. ... loggerheads, nesting increases since 2008 may be a recovery response ...
Cached Biology News:Ancestor of snakes, lizards likely gave birth to live young 2U-M tinnitus discovery opens door to possible new treatment avenues 2U-M tinnitus discovery opens door to possible new treatment avenues 3Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 2Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 3Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 4
(Date:7/25/2014)... , July 25, 2014 ... the "Global Metabolomics Market 2014-2018" report ... http://photos.prnewswire.com/prnh/20130307/600769 Metabolomics or Metabonomics is ... Metabolomics has become a new experimental technique that ... the environmental sciences. Metabolites are small molecules that ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 WABC Radio show ... Pet with Lorry Young will be hosting California-based Vet-Stem, ... about stem cell therapy in pets. Dr. Harman first ... of stem cell therapy for pets suffering from osteoarthritis and ... Regenerative Veterinary Medicine industry forward. , Young has invited Dr. ...
(Date:7/25/2014)... Lawrence Livermore scientists Charles Westbrook and William ... " The World's Most Influential Scientific Minds ." , ... who were identified by analyzing citation data over the ... highest-impact work (2002-2012 and 2012-2013). The two were selected ... . , "This recognition is a great honor for ...
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, ... for global corporations operating in highly regulated industries, ... first annual Global User Group Conference, Xybion International ... Philadelphia, Pennsylvania at the Sheraton ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s conference ...
Breaking Biology Technology:Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3
... Pharmaceuticals, Inc. (NYSE Amex: ANX ) today ... ended December 31, 2008."2008 was a transition year for ... focused on lower-risk reformulations of previously-approved drugs. We achieved ... the difficult economic environment, we were unable to attract ...
... Insmed Inc. (Nasdaq: INSM ), a developer of ... March 23, 2009, NASDAQ issued a notice further extending the ... price and those rules requiring a minimum market value of ... effect through Friday, July 17, 2009, and the original rules ...
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ... patient enrolment in its U.K. clinical trial to ... REOLYSIN(R) in combination with gemcitabine (Gemzar(R)) in patients ... neck. The principal investigators are Dr. Johann de ...
Cached Biology Technology:ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 2ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 3ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 4ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 5ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 6ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 7Insmed Announces That NASDAQ Further Extends Temporary Suspension of Minimum Bid Closing Price Rule 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 3
alpha/beta-Tubulin Antibody Ship: Hot Store: -20 C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: