Navigation Links
Canadian scientist mines drugs database for new diabetes treatment
Date:2/23/2009

A Canadian scientist, now based in the UK and funded by the UK Biotechnology and Biological Sciences Research Council, has harnessed a new drug discovery tool to identify a new player in the body's insulin secretion process. This finding could spark a completely new class of drugs to treat type 2 diabetes.

In work published this week in Nature Chemical Biology researchers at the University of Oxford, led by University of Saskatchewan graduate Dr Grant Churchill, explain how they have exploited new technology to create a cheap and efficient method of drug discovery that will allow small academic labs to search a large database of drugs to find treatments for diabetes and many other diseases. They have used this new method to identify a small molecule which they are using to understand how insulin is secreted in response to increases in blood sugar.

Dr Churchill said: "A lot of diseases are caused by problems with important proteins within cells. We need to find small molecules that change the function of these proteins both to discover how they work and in addition because these small molecules may also work as treatments for disease. The approach we have developed allows us to do this much more quickly and cheaply than many of the current methods. Ultimately this will speed up the process of getting better treatments into the clinic for patients."

Starting with a natural chemical and systematically modifying its chemical structure is a proven technique and common drugs such as beta-blockers and anti-histamines were discovered this way. However, these discoveries involved lengthy chemical syntheses starting with the natural chemical (adrenalin and histamine respectively).

"Our method also begins with the natural chemical but rather than modifying it with a time-consuming and expensive chemical syntheses conducted by a team of chemists, ours uses computers to identify corresponding small molecules for research and medicine. The major difference is that we have linked the computational methods commonly used by pharmaceutical companies to a freely available database of 5 million existing compounds the ZINC database. This means we cut out a hugely time consuming and financially intensive part of the process, which is difficult for small academic labs to do," Churchill said.

The team has tested their method by successfully identifying a small molecule called Ned-19. This molecule was found after information about the natural chemical NAADP was entered into the computer system and cross referenced with the ZINC database. In collaboration with scientists at the University of Southampton, led by A.Ganesan, Ned-19 was prepared on a larger scale and separated. Further experiments were carried out with these compounds to confirm the activity of Ned-19. Using Ned-19 in experiments they have discovered that NAADP plays a crucial role in insulin secretion and therefore represents a brand new target for diabetes drugs.

Churchill continued: "Unfortunately, asking someone to take Ned-19 would actually give them diabetes! But now that we know how important NAADP is we can start to look for drugs that work with NAADP to increase insulin secretion rather than decrease it. In fact, we have colleagues who are already working on this using our tool."

Professor Douglas Kell, BBSRC Chief Executive said: "This is great news for our community of researchers and will provide a powerful tool for research in the future. This discovery about insulin secretion shows how important it is to have centrally held data repositories that are free to access. Such sharing of data and information can have really significant impact, right across the board."


'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related biology news :

1. First images from medical beamline at Canadian Light Source
2. Massive Canadian oilfield could be exploited using new UK system
3. Canadian Society of Exercise Physiology Annual Scientific Conference
4. Ancient organisms discovered in Canadian gold mine
5. Scientists mine drugs database for new diabetes treatment
6. Atmospheric scientists trace the human role in Indonesian forest fires
7. Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses
8. Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses
9. Life secret exposed: Scientists unlock mystery of molecular machine
10. Scientists find black gold amidst overlooked data
11. Marine scientists to assess environment before offshore drilling begins in US arctic waters
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Research and Markets has announced the addition of the ... The report forecasts the biometrics ... a CAGR of 12.28% during the period 2016-2020. ... with inputs from industry experts. The report covers the market landscape ... includes a discussion of the key vendors operating in this market. ...
(Date:6/22/2016)... June 22, 2016  The American College of Medical Genetics ... Executive Magazine as one of the fastest-growing trade shows ... at the Bellagio in Las Vegas . ... percentage of growth in each of the following categories: net ... and number of attendees. The 2015 ACMG Annual Meeting was ...
(Date:6/22/2016)... , June 22, 2016   ... management and verification solutions, has partnered with ... software solutions for Visitor Management, Self-Service Kiosks ... provides products that add functional enhancements to ... provides corporations and venues with an automated ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), ... free webinar on Performing Quality Investigations: Getting to Root Cause. ... no charge. , Incomplete investigations are still a major concern to the Regulatory ...
(Date:6/22/2016)... June 22, 2016 Cell Applications, Inc. ... them to produce up to one billion human ... within one week. These high-quality, consistent stem cells ... cells and spend more time doing meaningful, relevant ... proprietary, high-volume manufacturing process that produces affordable, reliable ...
Breaking Biology Technology: