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Canadian researchers lead groundbreaking discovery in deadly childhood cancer
Date:12/11/2013

This news release is available in French.

MONTREAL, December 11th, 2013 A new study by Canadian researchers may pave the way for more effective treatment of an aggressive and deadly type of brain tumour, known as ETMR/ETANTR. The tumour, which is seen only in children under four, is almost always fatal, despite aggressive treatment. The study proposes a new model for how this brain tumour develops and suggests possible targets to investigate for novel therapies. These findings, recently published in Nature Genetics, also shed new light on the complex process of early brain development. The study was led by the Research Institute of the McGill University Health Centre (RI-MUHC), the McGill University and Genome Quebec Innovation Centre, and The Hospital for Sick Children (SickKids), and funded by the Cancer Research Society.

"We undertook this study because we wanted to learn what was driving the growth of these tumours and how best to treat them," says the study's co-principal investigator, Dr. Nada Jabado, hemato-oncologist at the Montreal Children's Hospital of the MUHC and an associate professor in the Department of Pediatrics at McGill University. "This is a very aggressive disease with poor outcomes for patients; we urgently need better treatments for these kids, and this study, which helps us better understand what happens in this tumour, moves us a little closer to that target."

"Our recent collaborations with Dr. Jabado's and Dr. Majewski's labs and other colleagues have provided opportunities to take our initial discovery of this entity closer to finding innovative treatments for this disease, which we believe is an important, yet under-recognized, infantile brain tumour, " says co-principal investigator Dr. Annie Huang, a brain tumour sp
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Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-934-1934 x71381
McGill University Health Centre
Source:Eurekalert

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