Navigation Links
Canadian researchers first worldwide to generate pluripotent stem cells from horses
Date:2/27/2011

This release is available in French.

In a world first, pluripotent stem cells have been generated from horses by a team of researchers led by Dr. Andras Nagy at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Dr. Lawrence Smith at the University of Montreal's Faculty of Veterinary Science. The findings will help enable new stem-cell based regenerative therapies in veterinary medicine, and because horses' muscle and tendon systems are similar to our own, aid the development of preclinical models leading to human applications. The study was published in the February 28 issue of the leading journal Stem Cell Reviews and Reports.

These induced pluripotent stem (iPS) cells can develop into most other cell types and are a source of great hope for use in regenerative medicine and the development of new drugs to prevent and treat various illnesses. One aspect of regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to damage or disease. "To date, iPS cells have been established from several species, but our study is the first to report the derivation of these changeable cells from horses," Dr. Smith explained.

The research represents a breakthrough for both human and animal health alike. "Equine iPS cells bring new therapeutic potential to the veterinary field, and open up the opportunity to validate stem-cell based therapies before clinical studies in humans," Dr. Nagy said. "As well, stem-cell based studies using the horse as a model more closely replicate human illnesses, when compared with studies in mice."

After two months of reprogramming equine somatic cells, the resulting iPS cell lines expressed hallmark markers of pluripotency, contained a correct set of horse chromosomes, and were able to form a full spectrum of cell types and tissues fulfilling the criteria of pluripotency. The term pluripotency refers to the ability of a stem cell to become any of the vast number of different cell types found in the body. "This means that the cell lines passed all the tests available to us for determining if they truly are what we think they are: pluripotent and a good source for future regenerative applications," said Kristina Nagy, research associate in the Nagy laboratory and lead author of the study.

"The horse is an excellent model for a range of human degenerative diseases, especially those involving joints, bones, tendons and ligaments, such as arthritis," said Dr. Sheila Laverty, a professor in the Faculty of Veterinary Medicine at the University of Montreal. "Bone fracture, as well as damaged cartilage, tendons and ligaments heal poorly in horses. Therefore, the use of iPS cells in these animals may help enhance long-term tissue repair." Further research will be required to develop clinical treatments.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology news :

1. First images from medical beamline at Canadian Light Source
2. Canadian scientist mines drugs database for new diabetes treatment
3. Fossil evidence of missing link in the origin of seals, sea lions, walruses found in Canadian Arctic
4. Canadian biomedical engineering pioneer receives international award
5. Canadian-based UN coral reef expert honored at world meeting in Australia
6. University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease
7. Canadian synchrotron conference sheds light on new biomedical research
8. Canadian excellence strengthened by extensive adoption of open access
9. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
10. Canadian scientists identify gene that makes water striders glide across water
11. Canadian research breakthrough holds promise for development of effective cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/1/2016)... , June 1, 2016 ... in Election Administration and Criminal Identification to Boost Global ... a recently released TechSci Research report, " Global Biometrics ... Region, Competition Forecast and Opportunities, 2011 - 2021", the ... billion by 2021, on account of growing security concerns ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Houston Methodist Willowbrook Hospital has ... Association to serve as their official health care ... Willowbrook will provide sponsorship support, athletic training services, ... coaches, volunteers, athletes and families. "We ... Association and to bring Houston Methodist quality services ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology: