Navigation Links
Canadian discoveries pivotal to the science of toxins and illness associated with E. coli
Date:10/29/2013

Many Canadian scientists and clinicians were unsung heroes during the early years (19771983) of research unfolding around verotoxigenic E. coli (VTEC). In an article published today in the Canadian Journal of Microbiology, Dr. Cimolai, a clinician and medical microbiologist, documents the history of this area of study, focusing on the key discoveries and major contributions made by Canadians to the science of what many people refer to as hamburger disease. This disease poses an ongoing and significant threat to the general population; examples of its impact are the Walkerton outbreak and recent meat tainting episodes affecting the beef production industry in Alberta, as well as food contamination in Europe.

Dr. Cimola writes As stories of microbiological and infectious disease discoveries are told, one of the most charming of these in Canadian history is the recognition of VTEC and associated disease. The considerable burden and impact of E. coli-associated infections is experienced worldwide. The contributions of our national scientists in this field must be seen as a vital part of medical and microbiological Canadiana.

Cimolai reports on key contributors, including Jack Konowalchuk, Joan Speirs and their collaborators in Ottawa, who defined the E. coli verotoxin; Mohamed Karmali, Martin Petric and colleagues at The Hospital for Sick Children in Toronto, who established the association of VTEC and hemolytic-uremic syndrome; Carlton Gyles, University of Guelph Veterinary School, and Peter Fleming, Hermy Lior and their scientific and medical peers. Many Canadian investigators, but especially those in the veterinary school at the University of Guelph, also contributed to the science of VTEC among animals. The interactions between clinical and veterinary researchers led to a then unprecedented exponential growth in the knowledge base of VTEC. The Toronto group led by Karmali stood front and centre during the most critical period of scientific progress, but certainly Konowalchuk et al.s findings were pivotal.

From a Canadian perspective, many sentinel and key observations emerged early in the general science of this topic, and as a Canadian, one can be proud of how quickly the essence of these contributions was disseminated across Canada and worldwide, explains Dr. Cimolai. While perhaps not as impactful as the Banting and Best story, perhaps it may be the next best thing in the realm of microbiology but with a Canadian flavour.

These toxin-producing E. coli are disease-causing bacteria and can cause episodes of diarrhea and bloody diarrhea. They can also lead to a complicated medical disorder known as hemolytic uremic syndrome, the most common acute form of serious kidney failure among children. It is also a major disease-causing germ among animals, but especially bovine and porcine; farm animals and their related food products can serve as a source for the bacterium to humans. Water can also be contaminated by these germs. The profound impact of disease from these toxigenic E. coli continues to be felt around the globe.


'/>"/>

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)
Source:Eurekalert

Related biology news :

1. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
2. Supplement use predicts folate status in Canadian women
3. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
4. Ducks Unlimited Canada and Canadian Light Source partnership to shed light on wetlands
5. 6th Annual Canadian Neuroscience Meeting, Vancouver, May 20-23, 2012
6. Advanced Photon Source and Canadian Light Source strengthen ties
7. Concern about plans to close unique Canadian environmental project
8. Canadian homes a kill zone for up to 22 million birds a year
9. Climate-smart strategies proposed for spectacular US-Canadian landscape
10. A European invader outcompetes Canadian plants even outside its usual temperature range
11. Canadians support interventions to reduce dietary salt
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... 2016 Yissum Research Development Company of ... of the Hebrew University, announced today the formation of ... of various human biological indicators. Neteera Technologies has completed ... private investors. ... of electromagnetic emissions from sweat ducts, enables reliable and ...
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
(Date:3/11/2016)... --> --> ... Recognition Market by Technology (Pattern Recognition), by Component (Hardware, ... Type (On-Premises and Cloud), by Industry Vertical and by ... the global market is expected to grow from USD ... 2020, at a CAGR of 19.1%. , ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... READING, England , May 26, ... ), a leading global provider of clinical, commercial ... healthcare organisations and TranScrip ( http://www.transcrip-partners.com ), a ... the product lifecycle, today announced the extension of ...      (Logo: http://photos.prnewswire.com/prnh/20141208/720248 ) ...
(Date:5/26/2016)... ... 26, 2016 , ... Kinder Scientific (KinderScientific.com), a leading animal ... the Company for the future. Kinder Scientific announces restructured ownership and additional ... appointed Chairman of the Board, Curtis D. Kinghorn has been appointed CEO/President and ...
(Date:5/25/2016)... ... May 25, 2016 , ... The ... fracture-specific plating options designed to address fractures of the distal tibia and fibula. ... The Acumed Ankle Plating System 3 is composed of seven plate families that ...
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading authority on the use ... W. Stellar has been named by the WEDI Board of Directors as WEDI’s president ... executive leader with more than 35 years of experience in healthcare, association management and ...
Breaking Biology Technology: