Navigation Links
Canadian discoveries pivotal to the science of toxins and illness associated with E. coli
Date:10/29/2013

Many Canadian scientists and clinicians were unsung heroes during the early years (19771983) of research unfolding around verotoxigenic E. coli (VTEC). In an article published today in the Canadian Journal of Microbiology, Dr. Cimolai, a clinician and medical microbiologist, documents the history of this area of study, focusing on the key discoveries and major contributions made by Canadians to the science of what many people refer to as hamburger disease. This disease poses an ongoing and significant threat to the general population; examples of its impact are the Walkerton outbreak and recent meat tainting episodes affecting the beef production industry in Alberta, as well as food contamination in Europe.

Dr. Cimola writes As stories of microbiological and infectious disease discoveries are told, one of the most charming of these in Canadian history is the recognition of VTEC and associated disease. The considerable burden and impact of E. coli-associated infections is experienced worldwide. The contributions of our national scientists in this field must be seen as a vital part of medical and microbiological Canadiana.

Cimolai reports on key contributors, including Jack Konowalchuk, Joan Speirs and their collaborators in Ottawa, who defined the E. coli verotoxin; Mohamed Karmali, Martin Petric and colleagues at The Hospital for Sick Children in Toronto, who established the association of VTEC and hemolytic-uremic syndrome; Carlton Gyles, University of Guelph Veterinary School, and Peter Fleming, Hermy Lior and their scientific and medical peers. Many Canadian investigators, but especially those in the veterinary school at the University of Guelph, also contributed to the science of VTEC among animals. The interactions between clinical and veterinary researchers led to a then unprecedented exponential growth in the knowledge base of VTEC. The Toronto group led by Karmali stood front and centre during the most critical period of scientific progress, but certainly Konowalchuk et al.s findings were pivotal.

From a Canadian perspective, many sentinel and key observations emerged early in the general science of this topic, and as a Canadian, one can be proud of how quickly the essence of these contributions was disseminated across Canada and worldwide, explains Dr. Cimolai. While perhaps not as impactful as the Banting and Best story, perhaps it may be the next best thing in the realm of microbiology but with a Canadian flavour.

These toxin-producing E. coli are disease-causing bacteria and can cause episodes of diarrhea and bloody diarrhea. They can also lead to a complicated medical disorder known as hemolytic uremic syndrome, the most common acute form of serious kidney failure among children. It is also a major disease-causing germ among animals, but especially bovine and porcine; farm animals and their related food products can serve as a source for the bacterium to humans. Water can also be contaminated by these germs. The profound impact of disease from these toxigenic E. coli continues to be felt around the globe.


'/>"/>

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)
Source:Eurekalert

Related biology news :

1. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
2. Supplement use predicts folate status in Canadian women
3. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
4. Ducks Unlimited Canada and Canadian Light Source partnership to shed light on wetlands
5. 6th Annual Canadian Neuroscience Meeting, Vancouver, May 20-23, 2012
6. Advanced Photon Source and Canadian Light Source strengthen ties
7. Concern about plans to close unique Canadian environmental project
8. Canadian homes a kill zone for up to 22 million birds a year
9. Climate-smart strategies proposed for spectacular US-Canadian landscape
10. A European invader outcompetes Canadian plants even outside its usual temperature range
11. Canadians support interventions to reduce dietary salt
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
(Date:3/23/2017)... 2017 Research and Markets has announced the ... Trends - Industry Forecast to 2025" report to their offering. ... The Global ... of around 8.8% over the next decade to reach approximately $14.21 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... scaffold technology, today announced the election of Paul Hermes, Entrepreneur in Residence at ... , Biorez has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... pathology, and Huron Digital Pathology , a provider of whole slide imaging ... Pathology Visions conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy for ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... the most dangerous step of sample prep for metals digestion—the addition of acids ... at an affordable price. The system is ideal for any laboratory performing their ...
(Date:9/19/2017)... Washington, D.C. (PRWEB) , ... September 19, 2017 ... ... care during an biological outbreak is about to be eliminated, said Lyle Probst, ... makes ExcitePCR’s FireflyDX™ technologies different than other pathogen detection solutions, Probst ...
Breaking Biology Technology: