Navigation Links
Can you be born a couch potato?
Date:7/16/2008

at, up until recently, research has ignored the possibility that activity is regulated by biological as much as by environmental factors. What's interesting is that there is a disconnect between the animal and the human literature in this researchers haven't been paying attention to the animal studies which, for example, have shown that that hormones affect activity."

Lightfoot's interest in the issue drew him to work with strains of mice that had markedly different behaviors when given an exercise wheel. A "high-active" strain scored notably higher than other strains in speed, duration and distance achieved in running than other strains, including one that was labeled as "aggressively sedentary" because of its consistent avoidance of activity.

At first, Lightfoot suspected that the difference was due to genetic factors affecting the way energy is used by muscle tissue because early genetic studies of the strains indicated that variation was present in genes known to affect metabolism. However, studies the team conducted on muscle tissue in the different mice failed to show a genetic effect that could cause a difference in muscle performance.

"We have done some gene chips on muscle tissue and we don't see any differential expression between high-active and low-active animals in peripheral (muscle) tissue," Lightfoot said. "So the suggestion that by over-expressing a glucose transporter we can increase activity doesn't seem to be the explanatory factor."

Subsequent studies have led the team to suspect that genetic differences are having a profound affect on mouse activity levels by causing significant differences in their brains.

"More and more what we are seeing is differences in brain chemistry. We are really convinced now that the difference is in the brain," Lightfoot said. "There is a drive to be more active."

The current studies interbred active and inactive strains of mice to re-sort the genes. The resear
'/>"/>

Contact: James Hathaway
jbhathaw@uncc.edu
704-687-6675
University of North Carolina at Charlotte
Source:Eurekalert

2

GOOD

Page: 1 2 3

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... "place" is increasingly being considered in the management ... new resource that can help them recognize and ... places in their lives. , Place-Based Conservation: ... co-edited by the Pacific Northwest Research Station,s Linda ... to conservation. The book is published by Springer ...
(Date:5/21/2013)... found that a class of pharmaceuticals can both prevent ... drugs, known as "TSPO ligands," are currently used for ... effects of TSPO ligand in young adult mice when ... mice when pathology was quite severe," said lead researcher ... "TSPO ligand reduced measures of pathology and improved behavior ...
(Date:5/21/2013)... of Michigan Water Center today awarded 12 research ... restoration and protection efforts. , The two-year grants ... including efforts to track the remediation of harmful ... control non-native weedy plant invasions; study chromosomal damage ... to restoration activities. , The grants were awarded ...
Breaking Biology News(10 mins):Drugs found to both prevent and treat Alzheimer's disease in mice 2U-M Water Center awards $570K in Great Lakes restoration grants 2U-M Water Center awards $570K in Great Lakes restoration grants 3U-M Water Center awards $570K in Great Lakes restoration grants 4
... dawn of the biological sciences, mankind has struggled to ... animals the arthropods. Now, a team of researchers, ... the Natural History Museum of Los Angeles County (NHM), ... relationships among the arthropods, answering many questions that defied ...
... engineer at the University of WisconsinMilwaukee (UWM) can not ... cell will produce, but also foresee the outcome before ... by Andrew Cohen, an assistant professor of electrical engineering, ... will allow scientists to search for mechanisms that control ...
... Benjamin Franklin,s advice that "an ounce of prevention ... applied to today,s most pressing health issue: obesity. Because ... preventing the progression of weight gain throughout life, especially ... area of great interest is the possibility that being ...
Cached Biology News:Where did insects come from? 2Where did insects come from? 3UWM researcher predicts stem cell fate with software 2UWM researcher predicts stem cell fate with software 3Later introduction of baby foods related to lower risk of obesity later in life 2
(Date:5/22/2013)... Alton Housing Authority was hit by bed bugs. A ... their presence has already caused the company $35,000 for treatment. ... spending, My Cleaning Products shared a way how to ... the report that to clear the infestation , the ... employees also attended a mandatory training on bed bugs, it ...
(Date:5/22/2013)... -- Moderna Therapeutics, the pioneering company developing messenger RNA therapeutics™, ... in vivo production of therapeutic proteins, announced today ... Moderna in early July as its first Chief Information ... in the design and implementation of information systems underlying ... clinical operations and commercial preparedness. John has also been ...
(Date:5/21/2013)... May 21, 2013 Custom Learning ... reporting eLearning solution using Tin Can API combined ... tool. CLD is a leading developer of training ... device companies worldwide. , Tin Can API ... helps learners and trainers more accurately measure the ...
(Date:5/21/2013)... May 21, 2013 The congress ... Transplant Association) is the biggest congress in ... Nearly 10,000 participants are in Istanbul ... research findings. New pioneering studies have been presented: ... PYROPHOSPHATE (SFP) ADMINISTERED VIA HEMODIALYSATE REDUCES ESA USE" ...
Breaking Biology Technology:Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 2Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer 3CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 2CLD Integrates Tin CAN API with its eLearning Solutions and Launches its Excelerometer Tracking Statement Dashboard 3ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3
... Stratagenes GeneConnection cDNA gene clusters are novel and more ... , Jason Goncalves Jean-Michel Lelias Joe Sorge ... YY ,goes beyond normal cDNA collections. Stratagene ... identified thousands of cDNAs that are not found ,in ...
... One column purification of protein with native amino ... Wyborski * John C. Bauer * Barbara McGowan ... Systems, Inc. , Stratagene has improved the Affinity ... the pCAL-n-EK vector. This E. coli,cloning and expression ...
... system provides quality images from,nanogram quantities of RNA , ... ,Stratagene , The SYBR Gold ... II still,video system, allows the integrity of only ... , In Stratagenes Custom Library Department, we often construct cDNA,libraries ...
Cached Biology Technology:The GeneZoo or the GeneJungle? 2The GeneZoo or the GeneJungle? 3The GeneZoo or the GeneJungle? 4The GeneZoo or the GeneJungle? 5The GeneZoo or the GeneJungle? 6The GeneZoo or the GeneJungle? 7The GeneZoo or the GeneJungle? 8The GeneZoo or the GeneJungle? 9The GeneZoo or the GeneJungle? 10Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 2Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 3Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 4Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 5Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 6Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 7Expression and Purification of Recombinant Proteins That Have Native Amino,Acid Sequence 8Improved Sensitivity for Staining RNA with SYBR Gold Stain 2Improved Sensitivity for Staining RNA with SYBR Gold Stain 3
Mouse Serpin F1/PEDF MAb (Clone 199315)...
Mouse Nodal Affinity Purified Polyclonal Ab...
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine Protease Regulators...
Biology Products: