Navigation Links
Can traumatic memories be erased?
Date:4/27/2011

Could veterans of war, rape victims and other people who have seen horrific crimes someday have the traumatic memories that haunt them weakened in their brains? In a new study, UCLA life scientists report a discovery that may make the reduction of such memories a reality.

"I think we will be able to alter memories someday to reduce the trauma from our brains," said the study's senior author, David Glanzman, a UCLA professor of integrative biology and physiology and of neurobiology.

The study appears in the April 27 issue of the Journal of Neuroscience, a premier neuroscience journal.

Glanzman, a cellular neuroscientist, and his colleagues report that they have eliminated, or at least substantially weakened, a long-term memory in both the marine snail known as Aplysia and neurons in a Petri dish. The researchers say they gaining important insights into the cell biology of long-term memory.

They discovered that the long-term memory for sensitization in the marine snail can be erased by inhibiting the activity of a specific protein kinase a class of molecules that modifies proteins by chemically adding to them a phosphate (an inorganic chemical), which changes the proteins' structure and activity. The protein kinase is called PKM (protein kinase M), a member of the class known as protein kinase C (PKC), which is associated with memory.

The research has important potential implications for the treatment of post-traumatic stress disorder, as well as drug addiction, in which memory plays an important role, and perhaps Alzheimer's disease and other long-term memory disorders.

"Almost all the processes that are involved in memory in the snail also have been shown to be involved in memory in the brains of mammals," said Glanzman, who added that the human brain is far too complicated to study directly.

PKM is rare in that while most protein kinases have both a catalytic domain, which is the
'/>"/>

Contact: Stuart Wolpert
swolpert@support.ucla.edu
310-206-0511
University of California - Los Angeles
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5 6

Related biology news :

1. UTHealth studies cord blood stem cells for pediatric traumatic brain injury
2. Drug prevents post-traumatic stress syndrome
3. Sangart, Inc. Announces Cooperative Research and Development Agreement With the U.S. Navy to Evaluate MP4 Molecule in Traumatic Brain Injury
4. Post-traumatic stress disorder diagnosed with magnetism
5. Alzheimers disease drug treats traumatic brain injury, report GUMC researchers
6. UT to develop fracture putty for traumatic leg injuries
7. New insight into aha memories
8. Enzyme enhances, erases long-term memories in rats
9. Where unconscious memories form
10. Half-a-loaf method can improve magnetic memories
11. Study shows genes role in developing and maintaining cells key for a lifetime of memories
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... Calif., May 22, 2013 Early screening for prostate ... pregnancy testing is for women, thanks to UC Irvine ... American Chemical Society . , After more than a ... way to clearly identify clinically usable markers for prostate ... detected far sooner, with greater accuracy and at dramatically ...
(Date:5/21/2013)... monitoring" device attached to a whale entangled in fishing ... lines changed a whale,s diving and swimming behavior. The ... eat and migrate, depletes their energy as they drag ... a slow death. , The scientists in this entanglement ... a two-year-old female North Atlantic right whale called Eg ...
(Date:5/21/2013)... that a class of pharmaceuticals can both prevent and ... known as "TSPO ligands," are currently used for certain ... of TSPO ligand in young adult mice when pathology ... when pathology was quite severe," said lead researcher Christian ... ligand reduced measures of pathology and improved behavior at ...
Breaking Biology News(10 mins):UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study reveals how fishing gear can cause slow death of whales 2Study reveals how fishing gear can cause slow death of whales 3Drugs found to both prevent and treat Alzheimer's disease in mice 2
... Researchers at the Umeå Plant Science Centre at the Swedish ... in our understanding of how plants control their flowering. In ... they show how a small molecule that is formed in ... it induces the formation of flowers. This knowledge can lead ...
... you burned your finger on a hot stove? Imagine what ... or feet all the time and know there's virtually nothing ... neuropathic pain, and it's a common complication of many diseases ... this type of pain, which is caused by damage to ...
... the University of Chicago and Argonne National Laboratory ... to study the relationship between biochemical fluctuations within ... it interacts with other cells and its environment. ... in cancer research, drug development and combating bioterrorism. ...
Cached Biology News:Long-sought flower-inducing molecule found 2Scientists use gene transfer technology and common virus to block neuropathic pain in animals 2Scientists use gene transfer technology and common virus to block neuropathic pain in animals 3Scientists use gene transfer technology and common virus to block neuropathic pain in animals 4Scientists use gene transfer technology and common virus to block neuropathic pain in animals 5Scientists create digital bacteria to forge advances in biomedical research 2Scientists create digital bacteria to forge advances in biomedical research 3
(Date:5/22/2013)... May 22, 2013 Industry leaders ... VA for the Oak Ridge National Laboratory’s ... take place at the Hilton Alexandria Mark Center. ... Technologies 2013 conference on June 18 - ... , AdSave, American Elements, Applied Research Associates, ARA, ...
(Date:5/22/2013)... BUFFALO, N.Y. , May 22, 2013 /PRNewswire/ ... exclusive license for a patent pending novel genomic ... a molecular diagnostic test that could help in ... (NEPC) prostate cancer.  Neuroendocrine prostate ... adenocarcinoma (PCA) that can arise de novo, but ...
(Date:5/22/2013)... AudioNotch is the ... treatment. AudioNotch is pleased to announce a partnership ... in both British Columbia and Alberta, Destination Hearing ... services. AudioNotch's tinnitus treatment program is now available ... Destination Hearing clinic, patients have the detection of ...
(Date:5/22/2013)... 22, 2013 A recent study from ... athletes to find that those who took probiotics were able ... from the study showed that in extreme heat conditions, probiotics ... their adult acne treatment explains what this new ... may help their skin condition. , While researchers tote ...
Breaking Biology Technology:Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 2Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 3Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 4Biodetection Technologies 2013 and Oak Ridge National Lab’s Biosurveillance Symposium to Bring Together Leading Organizations in Alexandria, VA from June 17-19, 2013 5Empire Genomics Licenses Novel DNA Biomarker for Use in Diagnosing and Creating a Companion Diagnostic Test for Neuroendocrine Prostate Cancer 2AudioNotch Tinnitus Treatment Launches Partnership With Destination Hearing 2Adult Acne Treatment, Probiotic Action Shares Insight on New Findings Between Probiotics and Heat Tolerance, and What It Means for Acne Sufferers 2
... WASHINGTON, June 15 Congressional Quarterly presents a 360-degree ... of follow-on versions of biotech drugs. This CQ Forum ... interest groups, and leading researchers regarding the complex structures ... possible? Will the availability of these products save money ...
... ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX ) ... of shares of convertible preferred stock pursuant to a registered ... of approximately $2 million. The preferred stock is convertible into ... investor at a price of $0.1105 per share. , ...
... Zentaris Inc. (NASDAQ: AEZS ; TSX: AEZ), ... oncology, today reported that patient follow-up in the open-label ... in benign prostatic hyperplasia (BPH) with its lead endocrinology ... the end of this week. Therefore, data analysis and ...
Cached Biology Technology:ADVENTRX Pharmaceuticals Announces Closing of Financing 2ADVENTRX Pharmaceuticals Announces Closing of Financing 3AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 2AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 3AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 4AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 5
Candida (IgG) -Ab EIA Sample Size: 5 l...
Automated centrifuge for the processing of microplates and tubes; can be integrated into automated process using inexpensive robotics due to its unique sample handling platform....
OptiBuffer is a fully optimised medium, designed for,the electroporation of eukaryotic cells. OptiBuffer,improves both transfection efficiencies and survival,rates over PBS or other standard culture...
...
Biology Products: