Navigation Links
Can cancer be turned against itself?
Date:2/4/2013

Though a small group of proteins, the family called Ras controls a large number of cellular functions, including cell growth, differentiation, and survival. And because the protein has a hand in cellular division, mutated Ras, which can be detected in one-third of all tumors, contributes to many human cancers by allowing for the rapid growth of diseased cells.

Now Prof. Yoel Kloog of Tel Aviv University's Department of Neurobiology, along with Dr. Itamar Goldstein of TAU's Sackler Faculty of Medicine and the Sheba Medical Center and their students Helly Vernitsky and Dr. Oded Rechavi, has found that oncogenic Ras, which promotes cancer development, can also alert the immune system to the presence of cancer cells.

For the first time, the researchers have shown the transfer of oncogenic Ras in human cells from melanoma cells to T cells, which belong to a group of white blood cells that are part of the immune system. This transfer allows the immune cells to gather crucial intelligence on what they are fighting and develop the necessary cytokines, or signalling molecules, to kill the melanoma cells.

Prof. Kloog suggests that a drug that enhances the transfer of the oncogene from the tumor to the immune cells is a potential therapy to augment the anti-cancer immune response. This research has been published in the Journal of Immunology.

Finding the tipping point

Although they found that immune cells often exchange proteins among themselves, the discovery that melanoma cells transfer mutated Ras is an intriguing first. And it's this initial transfer that begins what the researchers call a positive feedback loop.

In the lab, researchers incubated T-cells from patients with human melanoma cells that had originated from tumors to track the process of handing-off various proteins. They uncovered a circuit that runs between the cancer and immune cells. Once the melanoma cells pass oncogenic Ras to the T-c
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

Related biology news :

1. FASEB SRC announces conference: Gastrointestinal Tract XV: Epithelia, Microbes, Inflammation & Cancer
2. Pitt researchers reveal mechanism to halt cancer cell growth, discover potential therapy
3. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
4. How the tilt of a cell-surface receptor prevents cancer
5. The potential of psilocybin to alleviate psychological distress in cancer patients is revealed
6. Brupbacher Prize goes to cancer researcher Michael Karin
7. Damon Runyon Cancer Research Foundation grants prestigious awards to 17 young scientists
8. In breast cancer metastasis, researchers identify possible drug target
9. Planning for bacteria in cancer patients may help hospitals fight infections
10. TGen, Scottsdale Healthcare study shows drug combination extends pancreatic cancer patient survival
11. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... such as buying clothing not made in a sweat ... their own bags when they go shopping? According to ... Research , ethical consumption is motivated by a need ... into action. , "Advocates of ethical consumerism suggest that ... the products they choose, but unfortunately only a small ...
(Date:9/16/2014)... Sept. 16, 2014  Cross Match Technologies, a ... announced today the launch of its Verifier ® ... identity of an individual using their secure credentials ... rapidly reads credential documents with embedded biometric data ... the biometric to a live scan of their ...
(Date:9/15/2014)... (September 15, 2014) The so-called central dogma ... proteinhas long provided a simplified explanation for how ... organisms. , In reality, of course, the ... first articulated nearly 60 years ago by Nobel ... structure. For one, there are multiple types of ...
Breaking Biology News(10 mins):Why are consumers willing to spend more money on ethical products? 2Cross Match Launches New Identity Management Handheld Solution 2Scientists discover RNA modifications in some unexpected places 2
... discovery by UNC scientists describes how cells infected by ... called exosomes, changing their cellular "cargo" of proteins and ... the growth of recipient cells from benign to cancer-producing. ... effects and potentially manipulate other cells throughout the body. ...
... University of California, San Diego School of Medicine and ... approved drugs to more than 1,000 proteins in Mycobacterium ... avenues to repurpose these drugs to treat TB. ... Computational Biology . "Tuberculosis is currently one of ...
... study by researchers at the Johns Hopkins Bloomberg School of ... disease among male clients of the commercial sex industry in ... drug use as the primary transmission mode of all HIV ... of publication in the journal Sexually Transmitted Infections . ...
Cached Biology News:UNC scientists identify cellular communicators for cancer virus 2TB-drugome provides new targets for anti-tuberculosis drug discovery 2Study examines risk of heterosexual HIV transmission in China 2
(Date:9/16/2014)... 16, 2014 “Nature has developed, very ... that we desire in optical design,” said Joseph Shaw, ... University. “As we explore surfaces and structures at the ... were presented in San Diego in August during a ... Nature ” chaired by Shaw and Rongguang Liang of ...
(Date:9/16/2014)... phones to cars and flashlights, batteries play an ... companies constantly are seeking ways to improve battery ... using a water-based solution, researchers at the University ... efficient nuclear battery that could be used for ... in automobiles and also in complicated applications such ...
(Date:9/16/2014)... MA (PRWEB) September 16, 2014 CIRTEC ... of Brian Highley as CEO of CIRTEC. , ... exciting point for the Company.” noted Brian Highley. “The ... performance while sustaining strong organic growth over the past ... growth by continuing to improve and expand the services ...
(Date:9/16/2014)...  LABSCO, the leading specialty sales agent of ... office laboratories and alternate healthcare settings is proud ... will serve as Siemens Healthcare Diagnostics, exclusive sales ... a semi-exclusive sales distributor in specified POL market ... States . LABSCO will be responsible for ...
Breaking Biology Technology:Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5LABSCO Secures Alliance With Siemens Healthcare Diagnostics 2LABSCO Secures Alliance With Siemens Healthcare Diagnostics 3
... engine dedicated to recruiting exceptional talent to jobs at ... the most rewarding careers on the planet, but they ... StartUpHire website, www.startuphire.com , lists thousands of jobs ... investor, and more. Search agents allow users to ...
... (Pink Sheets: SYNJ), Reports that it has engaged in ... The job of the Director will be to coordinate ... Pinnacle Energy Division. The Company is currently considering ventures ... production, and microwave plasma physics. To that end, the ...
... NOVATO, Calif., March 18 BioMarin Pharmaceutical Inc. (Nasdaq: ... for clinical trial authorization (CTA) for BMN 110 or ... lysosomal storage disorder Mucopolysaccharidosis Type IVA (MPS IVA), or ... Kingdom Medicines and Healthcare Products Regulatory Agency (MHRA). BioMarin ...
Cached Biology Technology:StartUpHire Launches Comprehensive Search Engine for Jobs at Venture-Backed Companies 2StartUpHire Launches Comprehensive Search Engine for Jobs at Venture-Backed Companies 3Syndication Inc. Seeks 'DIRECTOR OF TECHNICAL ENGINEERING' for 'PINNACLE ENERGY' - Its New Alternative Energy Subsidiary 2BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA 2BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA 3BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA 4