Navigation Links
Can a virus fight cancer?
Date:7/25/2012

OTTAWA, July 25 Two Ottawa researchers are taking innovative approaches to improving virus-based cancer therapy with new funding from the Canadian Cancer Society.

Viruses that selectively target and kill cancer cells called oncolytic viruses are an exciting new avenue for treating cancer because healthy cells are spared and side effects are reduced. The problem is that many tumors are able to protect themselves by unleashing defense mechanisms that disarm these viruses.

Two researchers are each tackling this problem with creative approaches that involve delivering the viruses in combination with new drugs to make the treatments more effective than either would be alone.

Dr Jean-Simon Diallo of the Ottawa Hospital Research Institute is receiving $200,000 to study the use of a specially engineered virus given in combination with a novel type of drug to help the virus overcome the tumor's defense mechanisms. Using a unique mathematical model, he will use results from this newly funded research to predict the success of other drug-virus combinations.

Dr Diallo's highly innovative research proposes a creative solution to disarming tumors' defense mechanisms with novel drugs, while also accelerating development of oncolytic viruses through mathematical modeling.

Dr Robert Korneluk of the Children's Hospital of Eastern Ontario is receiving $200,000 to study whether the defense mechanisms that tumors use to protect themselves from viruses can be turned against them.

Dr Korneluk is studying a group of experimental drugs that are highly effective in killing cancer cells, particularly in the presence of a specific compound. This compound is produced both by the immune system and by cancer cells and can result in actually protecting the tumour cells from viruses. In Dr Korneluk's innovative project, he will test whether, when given in combination with a cancer-killing virus, these experimental drugs can effectively destroy cancer cells.

Dr Diallo and Dr Korneluk are two of 15 Ontario scientists to receive new funding for unique and creative research, the Canadian Cancer Society announced today.

"Ontario continues to produce innovative research that ranks among the best in the world. We are proud to support these new projects because they bring a unique perspective in our fight against cancer," says Mary Argent-Katwala, Director, Research, Canadian Cancer Society. "We keenly anticipate the impact that the research will have on the lives of all Canadians."

A total of 28 grants representing a $5.4 million investment across the country were announced today. The Canadian Cancer Society is the largest national charitable funder of cancer research in Canada. For more information about the Society's research funding, visit www.cancer.ca


'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Related biology news :

1. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
2. Virus discovered in Cultus Lake sport fish
3. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
4. Viruses linked to algae that control coral health
5. Levels of hepatitis C virus higher among African-Americans and males
6. Researchers moving towards ending threat of West Nile virus
7. Flu immunity is affected by how many viruses actually cause the infection
8. Gut microbes battle a common set of viruses shared by global populations
9. Brothers in arms: Commensal bacteria help fight viruses
10. Childhood virus infection linked to prolonged seizures with fever
11. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Dec. 7, 2016   Veridium , a ... appointment of new CEO James Stickland . ... decades of experience, has served in senior executive ... he specialized in expanding a pipeline of venture ... He most recently served as managing director of ...
(Date:12/6/2016)... Valencell , the leading innovator in performance biometric ... consecutive year of triple digit growth for its PerformTek ... 360 percent increase in companies who have acquired Valencell ... sales of its wrist and ear Benchmark™ sensor systems, ... hearables for fitness and healthcare applications. ...
(Date:12/5/2016)... 2016  The Office of Justice Programs, National ... Scans Enhance or Replace Medico Legal Autopsies?" on ... or replacing forensic autopsies with postmortem X-ray computed ... In response to recommendations made by The National ... scans as a potential component of medicolegal death ...
Breaking Biology News(10 mins):
(Date:1/13/2017)... , Jan 13, 2017 Research and ... Product, Manufacturing, Application - Global Forecast to 2021" report to ... ... 2021 from USD 3.39 Billion in 2016, at a CAGR of ... the basis of product, manufacturing type, and application. Factors such as ...
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci has been ... found among its diverse customer base. The latest entry in this field is ... including BTX and Bio-Rad. FireflySci is introducing three distinct varieties including a 10x1mm, ...
(Date:1/12/2017)... ... January 12, 2017 , ... Each year, Crain’s Detroit Business News ranks ... that evaluates the patent estate of a company, its impact and significance, and the ... leading the way in technologies that transform energy sources such as low dose X-ray ...
(Date:1/12/2017)... ... January 12, 2017 , ... After ... Lisa Rosendahl’s doctors gave her only a few months to live. Now a ... that has stabilized Rosendahl’s disease and increased both the quantity and quality of ...
Breaking Biology Technology: