Navigation Links
Can a virus fight cancer?
Date:7/25/2012

OTTAWA, July 25 Two Ottawa researchers are taking innovative approaches to improving virus-based cancer therapy with new funding from the Canadian Cancer Society.

Viruses that selectively target and kill cancer cells called oncolytic viruses are an exciting new avenue for treating cancer because healthy cells are spared and side effects are reduced. The problem is that many tumors are able to protect themselves by unleashing defense mechanisms that disarm these viruses.

Two researchers are each tackling this problem with creative approaches that involve delivering the viruses in combination with new drugs to make the treatments more effective than either would be alone.

Dr Jean-Simon Diallo of the Ottawa Hospital Research Institute is receiving $200,000 to study the use of a specially engineered virus given in combination with a novel type of drug to help the virus overcome the tumor's defense mechanisms. Using a unique mathematical model, he will use results from this newly funded research to predict the success of other drug-virus combinations.

Dr Diallo's highly innovative research proposes a creative solution to disarming tumors' defense mechanisms with novel drugs, while also accelerating development of oncolytic viruses through mathematical modeling.

Dr Robert Korneluk of the Children's Hospital of Eastern Ontario is receiving $200,000 to study whether the defense mechanisms that tumors use to protect themselves from viruses can be turned against them.

Dr Korneluk is studying a group of experimental drugs that are highly effective in killing cancer cells, particularly in the presence of a specific compound. This compound is produced both by the immune system and by cancer cells and can result in actually protecting the tumour cells from viruses. In Dr Korneluk's innovative project, he will test whether, when given in combination with a cancer-killing virus, these experimental drugs can effectively destroy cancer cells.

Dr Diallo and Dr Korneluk are two of 15 Ontario scientists to receive new funding for unique and creative research, the Canadian Cancer Society announced today.

"Ontario continues to produce innovative research that ranks among the best in the world. We are proud to support these new projects because they bring a unique perspective in our fight against cancer," says Mary Argent-Katwala, Director, Research, Canadian Cancer Society. "We keenly anticipate the impact that the research will have on the lives of all Canadians."

A total of 28 grants representing a $5.4 million investment across the country were announced today. The Canadian Cancer Society is the largest national charitable funder of cancer research in Canada. For more information about the Society's research funding, visit www.cancer.ca


'/>"/>

Contact: Adrienne Vienneau
avienneau@cheo.on.ca
613-737-7600 x4144
Children's Hospital of Eastern Ontario Research Institute
Source:Eurekalert

Related biology news :

1. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
2. Virus discovered in Cultus Lake sport fish
3. 3-D motion of cold virus offers hope for improved drugs using Australias fastest supercomputer
4. Viruses linked to algae that control coral health
5. Levels of hepatitis C virus higher among African-Americans and males
6. Researchers moving towards ending threat of West Nile virus
7. Flu immunity is affected by how many viruses actually cause the infection
8. Gut microbes battle a common set of viruses shared by global populations
9. Brothers in arms: Commensal bacteria help fight viruses
10. Childhood virus infection linked to prolonged seizures with fever
11. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... ... August 21, 2017 , ... Baltimore biotech firm, PathSensors, ... to bring its proprietary CANARY pathogen detection technology and high throughput testing solutions ... has purchased an undisclosed number of PathSensors’ Zephyr pathogen detection instruments and will ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... speakers for this two-part educational webinar, in which attendees will learn about the ... protein factor composition. Along with an overview of the development and validation of ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... they will feature Federal Hybrids, Inc. in an upcoming episode, scheduled to broadcast ... American Farmer will explore Federal Hybrids, the independent, family-owned seed company. Educating audiences ...
(Date:8/17/2017)... ... August 17, 2017 , ... ... news outlet had provided a research update on Aytu Bioscience and cited promising ... , According to Soulstring, prescription rates for Natesto® have more than doubled since ...
Breaking Biology Technology: