Navigation Links
Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
Date:4/22/2009

s with two arms is nature's way of ensuring a strong binding interaction."

As it turns out, this sort of double-armed binding is easier said than done--at least in the case of HIV.

In their PNAS paper, Bjorkman and Klein looked at the neutralization capabilities of two different monoclonal antibodies isolated from HIV-infected individuals. One, called b12, binds a protein known as gp120, which forms the upper portion of an HIV's protein spike. The other, 4E10, binds to gp41, which is found on a lower portion of the spike known as the stalk.

The researchers broke each of the antibodies down into their component parts and compared their abilities to bind and neutralize the virus. They found, as expected, that one-armed versions of the b12 antibody were less effective at neutralizing HIV than two-armed versions. When they looked at the 4E10 antibody, by comparison, they found that having two arms conferred almost no advantage over having only one arm. In addition, they found that larger versions of 4E10 were less effective than smaller ones. These results highlight potential obstacles that vaccines designed to elicit antibodies similar to 4E10 might face.

But b12 has its own obstacles to overcome as well. In fact, when the researchers looked more closely at their data, they realized that the benefits of having two arms--even for b12--were much smaller than those seen for antibodies against viruses like influenza. In other words, the body's natural anti-HIV antibodies are much less effective at neutralizing HIV than they should be.

But why?

"The story really starts to get interesting when we think about what the human immunodeficiency virus actually looks like," says Klein. Whereas a single influenza virus's surface is studded with approximately 450 spikes, he explains, the similarly sized HIV may have fewer than 15 spikes.

With spikes so few and far between, finding two that both fall within the rea
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UNC, Caltech research finds further evidence for genetic contribution to autism
2. Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes
3. Caltech scientists awarded $20 million to Power the Planet
4. Caltech neurobiologists discover individuals who hear movement
5. Caltech engineers build mini drug-producing biofactories in yeast
6. Caltech researchers awarded $10M for molecular programming project
7. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
8. Caltech biologists spy on the secret inner life of a cell
9. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
10. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
(Date:9/1/2014)... microscopy revealed the presence of tiny blob-like structures that ... still don,t know what they do even though ... be crucial to the life of a cell, and ... In the Journal of Cell Biology , two ... backgrounds, from biophysics to cell biology, to focus their ...
(Date:8/31/2014)... highly infectious bacteria C. diff , that causes ... a team at the University of Leicester. , Using ... it is possible to identify the unique ,smell, of ... diagnosis of the condition., What is more, the Leicester ... strains of the disease simply from their smell ...
(Date:8/31/2014)... several decades, malaria diagnosis has changed very little. After taking ... blood across a glass slide, stains it with a special ... which causes the disease. This approach gives an accurate count ... important measure of disease severity but is not ideal ... team from the Singapore-MIT Alliance for Research and Technology (SMART) ...
Breaking Biology News(10 mins):Scientists call for investigation of mysterious cloud-like collections in cells 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2A new way to diagnose malaria 2A new way to diagnose malaria 3
... - When a reactor in the Chernobyl nuclear power ... Soviet republic of Ukraine, radioactive elements were released in ... and even eastern portions of North America. , ... Reserve University traveled to Sweden and Poland to gain ...
... [October 1, 2008] Sirtris, a GSK company focused ... diseases of aging such as Type 2 Diabetes, announced ... the growing body of sirtuin research and its potential ... Diabetes, mitochondrial disorders, inflammation, cancer, and heart disease. ...
... employs shade trees may improve crops, resistance to temperature ... trigger, according to an article published in the October ... B. Lin, Ivette Perfecto, and John Vandermeer, of the ... conclusions could be applicable to other economically important crops, ...
Cached Biology News:Case Western Reserve University researchers track Chernobyl fallout 2Sirtris' review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery 2
(Date:8/29/2014)... 29, 2014 According to a new market ... global orthobiologics market was valued at USD 3,754.6 million in ... 5,519.9million in 2019at a CAGR of 5.9% from 2013 to ... and above is afflicted by bone and joint disorders, and ... 2020. This has and will continue to increase the demand ...
(Date:8/29/2014)... Three Lawrence Livermore researchers have received ... R&D Award for their research in producing ... , Shared with collaborators from the National Renewable ... Las Vegas (UNLV), the award recognizes the team ... production and corrosion processes. , These models have ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... new research platform uses a laser to ... undergoing stress and heating, an approach likely ... microelectronics and batteries., This new technique, called ... heating and the surface stress of microscale ... discussed the merits of surface-stress influence on ...
Breaking Biology Technology:Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... two-year state budget signed into law Monday by Gov. ... Wisconsin technology firms by changing how corporate income from ... Technology Council. , ,With bipartisan support from the ... factor" sales apportionment for corporate income to technology and ...
... Wis. Sir Winston Churchill was once ... all the others that have been tried." Certainly one ... a confusion of popularity with leadership, and this poses ... the snippy comments, eroding voter participation and the occasional ...
... Fiserv, Inc ., a provider information management ... industries has signed a definitive agreement to acquire ... payment services. , ,BillMatrix, founded in 1994, provides ... customers to get immediate credit for bills paid online ...
Cached Biology Technology:`Single-sales factor' extends tax treatment to tech, service firms 2`Single-sales factor' extends tax treatment to tech, service firms 3IT - Does everybody get a vote? 2IT - Does everybody get a vote? 3