Navigation Links
Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
Date:4/22/2009

PASADENA, Calif.--Some 25 years after the AIDS epidemic spawned a worldwide search for an effective vaccine against the human immunodeficiency virus (HIV), progress in the field seems to have effectively become stalled. The reason? According to new findings from a team of researchers from the California Institute of Technology (Caltech), it's at least partly due to the fact that our body's natural HIV antibodies simply don't have a long enough reach to effectively neutralize the viruses they are meant to target.

Their findings were published last week in the online early edition of the Proceedings of the National Academy of Sciences (PNAS).

"This study helps to clarify the obstacles that antibodies face in blocking infection," says Pamela Bjorkman, the Max Delbrck Professor of Biology at Caltech and a Howard Hughes Medical Institute Investigator, "and will hopefully shed more light on why developing an effective vaccine for HIV has proven so elusive."

Y-shaped antibodies are best at neutralizing viruses--i.e., blocking their entry into cells and preventing infection--when both arms of the Y are able to reach out and bind to their target proteins at more or less the same time. In the case of HIV, antibodies that can block infection target the proteins that stud the surface of the virus, which stick out like spikes from the viral membrane. But an antibody can only bind to two spikes at the same time if those spikes fall within its span--the distance the antibody's structure allows it to stretch its two arms.

"When both arms of an antibody are able to bind to a virus at the same time," says Joshua Klein, a Caltech graduate student in biochemistry and molecular biophysics and the PNAS paper's first author, "there can be a hundred- to thousandfold increase in the strength of the interaction, which can sometimes translate into an equally dramatic increase in its ability to neutralize a virus. Having antibodie
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UNC, Caltech research finds further evidence for genetic contribution to autism
2. Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes
3. Caltech scientists awarded $20 million to Power the Planet
4. Caltech neurobiologists discover individuals who hear movement
5. Caltech engineers build mini drug-producing biofactories in yeast
6. Caltech researchers awarded $10M for molecular programming project
7. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
8. Caltech biologists spy on the secret inner life of a cell
9. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
10. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ... of the "iPhone 5S Fingerprint Sensor - ... report to their offering. ... of AuthenTec in July 2012, Apple introduced the ... is currently the only device of Apple incorporating ...
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014 /PRNewswire-USNewswire/ ... a Good Clinical Practices (GCP) audit to confirm ... Administration (FDA) regulations. This accomplishment enables HITLAB to ... trials utilizing the highest principles for patient safety ... to improve global healthcare access, quality, and delivery ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... When Conservation International began working with one of ... plan two years ago, the groups looked to a ... The University of Texas at Austin and leader in ... and energy producers to develop strategies that balance economic ...
... reporting first use of a new method that may ... reuse nanoparticles, some of which ounce for ounce can ... a solution to a nagging problem, could speed application ... electronic displays, and other products, the scientists suggest. Their ...
... for military and security uses so soldiers can track ... officials can unobtrusively identify a subject from an iris ... on "Panoptes," a platform technology developed under a project ... Dallas. The Department of Defense is funding development of ...
Cached Biology News:Philosopher brings human values to environmental decisions 2Philosopher brings human values to environmental decisions 3DOD funds tiny cave camera and iris recognition technology for military, homeland security 2DOD funds tiny cave camera and iris recognition technology for military, homeland security 3DOD funds tiny cave camera and iris recognition technology for military, homeland security 4
(Date:12/24/2014)... MD (PRWEB) December 23, 2014 ... into law H.R. 83, the Omnibus and Continuing ... first time, made hydrocephalus a condition eligible to ... Programs (CDMRP) administered by the Department of Defense ... with its allies on Capitol Hill, is celebrating ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. ... American Society for Reproductive Medicine (ASRM), a leading professional ... medicine. In his new role as treasurer, Dr. ... and will have a voice in furthering the mission ... ASRM since 1984 when he joined while conducting fellowship ...
(Date:12/24/2014)... China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... Shandong Taibang Biological Products Co. Ltd., has received ... Food and Drug Administration (the "CFDA") for its ... in the Company,s public filings, the CFDA inspected ...
(Date:12/24/2014)... 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... period under the Hart-Scott-Rodino Antitrust Improvements Act (HSR ... December 22, 2014, thereby completing the U.S. HSR ... acquisition of the Company by Merck KGaA, Darmstadt, ... another condition to closing the transaction, which remains ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3
... Relationship increases access to testing for sleep-related illnesses , ... a California-based provider of in-home sleep testing and Continuous ... with Aetna, one of the nation,s largest healthcare benefit ... will now be able to serve more patients with ...
... Six prestigious members of the National Institutes of Health ... ), the nation,s leading online jobs board and careers ... NIH has the highest number of post-doctoral professionals at ... organizations that have joined include the National Institute of ...
... Wound Care Innovations, LLC, a subsidiary of Wound ... reached an agreement in principle to acquire BioPharma Management ... platform of proprietary and patented technologies for topical pain ... structured as a share exchange pursuant to which BioPharma ...
Cached Biology Technology:SleepQuest Signs National Contract With Aetna 2National Institutes of Health Join Nation's Leading Postgrad Bio Jobs Board 2National Institutes of Health Join Nation's Leading Postgrad Bio Jobs Board 3Wound Management Technologies, Inc. Announced Today That It Has Reached an Agreement in Principal to Acquire BioPharma Management Technologies, Inc. 2
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
... cycler system is used for conventional PCR ... the MyCycler personal thermal cycler, which features ... 0.2 ml tubes or plates, programmable time, ... and block modes of temperature control. The ...
... ProteinChip arrays have been developed for ... samples. A variety of ProteinChip chemical ... according to their unique biochemical properties. ... allowing side-by-side sample comparison, and the ...
The Freeze 'N Squeeze DNA gel extraction kit uses a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. The kit includes materials for 100 preps....
Biology Products: