Navigation Links
Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
Date:4/22/2009

PASADENA, Calif.--Some 25 years after the AIDS epidemic spawned a worldwide search for an effective vaccine against the human immunodeficiency virus (HIV), progress in the field seems to have effectively become stalled. The reason? According to new findings from a team of researchers from the California Institute of Technology (Caltech), it's at least partly due to the fact that our body's natural HIV antibodies simply don't have a long enough reach to effectively neutralize the viruses they are meant to target.

Their findings were published last week in the online early edition of the Proceedings of the National Academy of Sciences (PNAS).

"This study helps to clarify the obstacles that antibodies face in blocking infection," says Pamela Bjorkman, the Max Delbrck Professor of Biology at Caltech and a Howard Hughes Medical Institute Investigator, "and will hopefully shed more light on why developing an effective vaccine for HIV has proven so elusive."

Y-shaped antibodies are best at neutralizing viruses--i.e., blocking their entry into cells and preventing infection--when both arms of the Y are able to reach out and bind to their target proteins at more or less the same time. In the case of HIV, antibodies that can block infection target the proteins that stud the surface of the virus, which stick out like spikes from the viral membrane. But an antibody can only bind to two spikes at the same time if those spikes fall within its span--the distance the antibody's structure allows it to stretch its two arms.

"When both arms of an antibody are able to bind to a virus at the same time," says Joshua Klein, a Caltech graduate student in biochemistry and molecular biophysics and the PNAS paper's first author, "there can be a hundred- to thousandfold increase in the strength of the interaction, which can sometimes translate into an equally dramatic increase in its ability to neutralize a virus. Having antibodie
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UNC, Caltech research finds further evidence for genetic contribution to autism
2. Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes
3. Caltech scientists awarded $20 million to Power the Planet
4. Caltech neurobiologists discover individuals who hear movement
5. Caltech engineers build mini drug-producing biofactories in yeast
6. Caltech researchers awarded $10M for molecular programming project
7. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
8. Caltech biologists spy on the secret inner life of a cell
9. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
10. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
11. Caltech geobiologists discover unique magnetic death star fossil
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
(Date:7/22/2014)... Conn. , July 22, 2014 ... the growing m-commerce market, announces its next generation smart ... 30-minute consumer oriented television show that airs on ... NewsWatch regularly features top technology ... July 31st on the History Channel (6:00-6:30am ET/PT) ...
(Date:7/22/2014)... 22, 2014, Cleveland: A type of immune cell ... such as Alzheimer,s disease and multiple sclerosis (MS), ... injury (TBI) and may slow the progression of ... today in the online journal Nature Communications ... Trapp, PhD, Chair of the Department of Neurosciences ...
(Date:7/22/2014)... much is known about the the genus of planthopper ... a new one was recently discovered in the southern ... of Jaen. A description of it appears in the ... http://www.insectscience.org/14.92/ ). , The new species, Conosimus baenai ... hemipterologist, for his contributions to the taxonomy of Iberian ...
Breaking Biology News(10 mins):NXT-ID's Next Generation Wocket Smart Wallet to be Featured on NewsWatch, Airing on History Channel, FYI Network and ION Network 2NXT-ID's Next Generation Wocket Smart Wallet to be Featured on NewsWatch, Airing on History Channel, FYI Network and ION Network 3Cleveland Clinic researchers discover neuroprotective role of immune cell 2
... BOSTON (9-24-09) -- The National Institutes of Health today ... led by Boston University biomedical engineer Bela Suki that ... function, with the goal of understanding the possible roles ... metabolic disorders, aging and cancer. NIH today announced ...
... , , , SAN ... the leader in on-demand identity intelligence, announced today its ... U.S. General Services Administration (GSA) Schedule. Under ... identity scoring technology currently used in the daily operations of ...
... part of an effort to develop effective medical therapies that ... Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University ... cyst walls develop and maintain a vasculature as they grow ... released by epithelial cells that line the liver cyst wall ...
Cached Biology News:Boston University engineer to use $2.5 million NIH grant to cells' reaction to physical force 2ID Analytics Expands Availability of On-Demand Identity Intelligence Solutions for the Government Market 2ID Analytics Expands Availability of On-Demand Identity Intelligence Solutions for the Government Market 3ID Analytics Expands Availability of On-Demand Identity Intelligence Solutions for the Government Market 4The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts 2
(Date:7/22/2014)... In chemical and petrochemical plants, and ... The rapid rise of TDL analyzers over recent ... a core gas measurement technology, and their high ... gas analyzer technology of choice for many companies. ... processes have limited their application range. METTLER TOLEDO's ...
(Date:7/22/2014)... July 22, 2014  Semler Scientific, Inc. (Nasdaq: ... risk assessment company that develops patented products that ... chronic diseases, today announced that it will report ... of U.S. financial markets on July 25, 2014. Doug Murphy-Chutorian, ... a conference call at 11 a.m. EDT, July 25, 2014. ...
(Date:7/22/2014)... 22, 2014  The Broad Institute today announced ... Ted Stanley aimed at galvanizing scientific ... based on molecular understanding to hundreds of millions ... The Stanley commitment – the largest ever in ... research in general – will support research by ...
(Date:7/22/2014)... 22, 2014 Quorum Review IRB, the industry ... large clinical trials called Quick Step™ . The offering ... address the research industry’s need for seamless study start-up with ... available for studies planning 50 or more North American investigator ... North American site count of 80 or more. Qualifying studies ...
Breaking Biology Technology:METTLER TOLEDO Shows How Tunable Diode Lasers (TDLs) Can Be Installed Where No TDLs Have Gone Before 2Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3
... one Delaware man,s vision,comes true, Americans will become ... with breast cancer, and to get started on ... an awareness campaign in his home state this,month., ... Tumor Foundation,and early this month kicked off a ...
... Agreement with U.S. Attorney,s, Office for Eastern District of ... Settles State Cases with ... Cephalon, Inc. (Nasdaq:,CEPH) announced today it has finalized a ... for the Eastern District of,Pennsylvania, the U.S. Department of ...
... Publications --, BRITISH COLUMBIA, Canada, Sept. 29 ... VENTURE: IXS;, http://www.ixsbio.com ), a drug development company ... its Dynamic Cross Linking,(DXL(TM)) technology, announces Jeff Morhet, ... company also announces the featuring of,Mr. Morhet in ...
Cached Biology Technology:Delaware Man Spearheads Brain Tumor Awareness 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 3Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 4InNexus Biotechnology CEO to Present at BioContactQuebec 2008 2
Recombinant Mouse MMP-9, CF...
Phosphorylcholine hapten is conjugated to BSA protein by use of p-diazonium phenylphosphorylcholine....
Human/Mouse/Rat JNK Pan Specific Affinity Purified PAb...
TAR DNA binding protein...
Biology Products: