Navigation Links
Caltech scientists show function of helical band in heart
Date:12/1/2008

PASADENA, Calif.--Scientists from the California Institute of Technology (Caltech) have created images of the heart's muscular layer that show, for the first time, the connection between the configuration of those muscles and the way the human heart contracts.

More precisely, they showed that the muscular band--which wraps around the inner chambers of the heart in a helix--is actually a sort of twisting highway along which each contraction of the heart travels.

Their findings were published in the December issue of the American Physiological Society journal, Heart and Circulatory Physiology.

Since the days of Leonardo da Vinci, observers of the human body have known that the heart's beat is not a simple in-and-out movement--that it has more than a little bit of a twist to it. "The heart twists to push blood out the same way you twist a wet towel to wring water out of it," explains Morteza Gharib, the principal investigator on the study, and the Hans W. Liepmann Professor of Aeronautics and professor of bioengineering in the Division of Engineering and Applied Science at Caltech.

Some 50 years ago, anatomist Francisco Torrent-Guasp was the first to show the helical configuration of the heart's myocardium--its muscular middle layer, the one that contracts with each heart beat.

But what he and subsequent generations of scientists were unable to do was to connect that myocardial band to the heart's function--to prove that the helical shape is important to the effective beating of the heart. Without that connection, physicians and scientists have tended to look at the heart as "just a piece of meat," says Gharib.

Until now, that is. Using a technique pioneered by Han Wen and his team at the National Institutes of Health, Gharib and his colleague Abbas Nasiraei Moghaddam, a Caltech graduate and visitor in bioengineering, were able to create some of the first dynamic images of normal myocardium in action at the tissue level. "We tagged and traced small tissue elements in the heart, and looked at them in space, so we could see how they moved when the heart contracts," Gharib explains. "In this way, we were able to see where the maximum physical contraction occurs in the heart and when--and to show that it follows this intriguing helical loop."

With each beat of the heart, a wave of contraction starts at the heart's apex--which, despite its name, is actually at the very bottom of the heart--and then travels up through the myocardium. "The only time the whole helix shows up in the images is at the end of systole, which is when the heart is contracting," says Gharib. "This simple band structure is akin to an engine behind the heart pumping action."

In addition to going a long way toward settling the decades-long structure/function debate surrounding Torrent-Guasp's work, this finding also has major implications for the surgical treatment of heart disease, Gharib says. "It's going to change the way we repair the heart," he explains. Knowing that the contractile wave travels along the helical pathway--instead of occurring throughout the heart all at once--has implications for which parts of the heart will be most vulnerable to a surgeon's scalpel, for instance. "Seventy-five percent of the function of the heart depends on this muscle," Gharib says. "Surgeons now know what to cut and what not to cut. This will help them to come up with new and more effective surgical procedures."


'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert

Related biology news :

1. Caltech scientists develop barcode chip for cheap, fast blood tests
2. Celebrated UH researcher invited to Caltech as distinguished scholar
3. Caltech researchers get first 3-D glimpse of bacterial cell-wall architecture
4. Caltech-led researchers find negative cues from appearance alone matter for real elections
5. Caltech geobiologists discover unique magnetic death star fossil
6. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
7. Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
8. Caltech biologists spy on the secret inner life of a cell
9. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
10. Caltech researchers awarded $10M for molecular programming project
11. Caltech engineers build mini drug-producing biofactories in yeast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... today announced the launch of the Supplyframe Design Lab . Located in ... to explore the future of how hardware projects are designed, built and brought ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: