Navigation Links
Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells
Date:9/24/2009

a search for better conditions."

"One of the remarkable things about this system," says Jensen, "is that the chemoreceptors are exquisitely sensitive to changes in the concentrations of positive and negative stimuli."

Scientists believe that this sensitivity is due to the way the hundreds of chemoreceptors cluster together in the bacterial cell. "It is known that if one receptor binds a stimulus molecule, it turns on other receptors around it as well to amplify the signal," Jensen explains. "The whole system also adapts to changing conditions, dynamically adjusting the range of concentrations that it responds to."

To fully understand just what is happening in these cells, Jensen says, it is thus important to figure out the ways in which these receptors interact with one another, which in turn depends on understanding precisely how they are situated in relation to one another.

In other words, scientists need to be able to "see" the internal architecture of the bacterial cell and, in particular, how its chemoreceptors are arrayed.

Jensen and his team were able to get just such a glimpse at the chemoreceptor architecture at the macromolecular level, thanks to a state-of-the-art electron cryomicroscope that was purchased with a gift from the Gordon and Betty Moore Foundation.

"The electron cryomicroscope allows us to see the arrangement of individual proteins inside cells in a lifelike state," says Jensen. "To do this, living cells are quickly frozen so that all the proteins are frozen in placein the same places they were in the living state."

The high-tech microscope allowed the researchers to take 3-D images of intact cells through a technique called electron cryotomography. The researchers looked at some 700 tomographic imagesor tomogramsof bacterial cells, says Caltech postdoctoral scholar Ariane Briegel, the first author on the PNAS paper, and an HHMI associate. "This is the first time such
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Caltech neuroscientists find brain region responsible for our sense of personal space
2. Caltech researchers explore how cells reconcile mixed messages in decisions about growth
3. Caltech scientists reveal how neuronal activity is timed in brains memory-making circuits
4. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
5. Caltech scientists control complex nucleation processes using DNA origami seeds
6. Caltech researchers train computers to analyze fruit-fly behavior
7. Caltech and UCSD researchers shed light on how proteins find their shapes
8. Caltech researchers help unlock the secrets of gene regulatory networks
9. Caltech researchers get first look at how groups of cells coordinate their movements
10. Caltech scientists show function of helical band in heart
11. Caltech scientists develop barcode chip for cheap, fast blood tests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells
(Date:10/22/2014)... JOSE, Calif. , Oct. 20, 2014 ... the United States Air Force Research Laboratory (AFRL), has ... Integrative Medicine (AzCIM) at the University of Arizona College ... receive research funding.  The AzCIM project,s goal is to ... ability to collect different volumes of sweat under a ...
(Date:10/22/2014)... Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its third quarter ended September 30, 2014. Revenue ... increase of 40% compared to $4.3 million in the same ... 2014 was $4.1 million compared to $1.0 million in the ... three month period was primarily due to: i) a $1.0 ...
(Date:10/18/2014)... stress-related psychiatric disorders are associated with increased ... mechanisms underlying this relation are unknown. Understanding ... of targeted preventive strategies and new or ... work is presented at the European College ... international group of researchers from Germany and ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 2Nano-Bio Manufacturing Consortium Selects Project Proposed by Arizona Center for Integrative Medicine to Optimize Human Performance Monitoring Techniques 3Aware, Inc. Reports Third Quarter 2014 Financial Results 2Aware, Inc. Reports Third Quarter 2014 Financial Results 3Aware, Inc. Reports Third Quarter 2014 Financial Results 4Aware, Inc. Reports Third Quarter 2014 Financial Results 5Aware, Inc. Reports Third Quarter 2014 Financial Results 6Aware, Inc. Reports Third Quarter 2014 Financial Results 7Researchers find why depression and aging linked to increased disease risk 2
... drop in public concern over global warming, Americansregardless of political ... to the results of a national survey released today by ... survey found support for: , Funding more research ... percent) Tax rebates for people buying fuel-efficient vehicles ...
... , BLUE BELL, Pa. , Feb. ... announced that its Mexican subsidiary has been awarded a contract ... of Internal Affairs/National Citizen Registry) to create and manage an ... create a database with iris, fingerprint and facial biometric data ...
... available in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2010-02/sfeb-cbc020310.php,">Chinese . ... do Paran and Instituto Carlos Chagas have ... expanded CD133+ cells human umbilical cord blood ... injecting them into a rat model. Patients ...
Cached Biology News:According to new survey, Americans support strong climate, energy policies 2Unisys Awarded Contract to Provide Advanced Biometric Citizen Identification Solution to Government of Mexico 2Unisys Awarded Contract to Provide Advanced Biometric Citizen Identification Solution to Government of Mexico 3
(Date:10/20/2014)... October 20, 2014 Convey Computer ... a team from Iowa State University won first place ... Using a Convey HC-2ex, the team’s solution achieved the ... faster than the second place finisher. , Experts from ... upon the month long challenge, using a variety of ...
(Date:10/20/2014)... , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... million which brings Q3 orders to $5.8 million and provides a ... projects in North America and one in ... to bid new projects at record levels," said Peter Bruijns ... higher at the end of Q3 than they have been for ...
(Date:10/20/2014)... GAITHERSBURG, Md. , Oct. 20, 2014  GenVec, Inc. ... Zola P. Horovitz , Ph.D., from its board of ... GenVec board in August 2003, and served as its chairman ... also served on the Nominating and Corporate Governance and Audit ... Zola for more than a decade of dedicated service to ...
(Date:10/20/2014)... 20, 2014 OncLive® ... Cancer Center at Thomas Jefferson University has joined ... the Strategic Alliance Partnership program, the Sidney Kimmel ... to raise awareness of the Center’s cutting-edge research ... projects. Clinicians and other health care professionals from ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... ICLL) today announced that the Australian Therapeutic Goods,Administration ... to,prevent Japanese Encephalitis. This final decision step for ... Australian Drug Evaluation,Committee (ADEC) in December 2008. , ... Australian authorities represents the first,regulatory approval for the ...
... Aerolase Corporation, a leading manufacturer of next-generation portable ... sales increased dramatically in 2008 over 2007. The ... market helped to more than offset current economic ... record sales month for Aerolase, and 2008 overall ...
... Jan. 23 Peter T. Wilderotter, president and CEO ... following statement today in response to FDA clearance of ... is an exciting first step for Geron and for ... to advances in medical research. There has been so ...
Cached Biology Technology:Australian Authorities (TGA) First to Grant Final Product Approval for Intercell's Vaccine to Prevent Japanese Encephalitis 2Australian Authorities (TGA) First to Grant Final Product Approval for Intercell's Vaccine to Prevent Japanese Encephalitis 3Australian Authorities (TGA) First to Grant Final Product Approval for Intercell's Vaccine to Prevent Japanese Encephalitis 4Aerolase Reports Strong Sales in 2008 for Portable Aesthetic Lasers 2Aerolase Reports Strong Sales in 2008 for Portable Aesthetic Lasers 3Christopher and Dana Reeve Foundation Response to FDA Clearance of Geron's Clinical Trial 2
... for the fast and simple integration of ... position (for the generation of transgenic mouse ... to allow neomycin / kanamycin selection in ... prokaryotic promoter (gb2) for expression of kanamycin ...
Includes a choice of any 3 EasySep mouse selection kits and EasySep magnet...
... These 1.5L PYREX trypsinizing flasks ... tissue samples into cell suspensions ... Heavy beaded neck accepts cotton ... vigorous agitation. • Height of ...
... Application: For the efficient enrichment ... mammalian tissue or cell culture. The ... synthesis, degradation and metabolic pathway analysis. ... acetyltransferase deficiency in children, cystic fibrosis ...
Biology Products: