Navigation Links
Caltech scientists describe the delicate balance in the brain that controls fear
Date:11/10/2010

r-based psychiatric illnesses like post-traumatic stress disorder, phobias, or anxiety disorders."

The key to understanding this delicate mechanism, Anderson says, was in uncovering "markers"genes that would identify and allow for the scientists to discriminate between the different neuronal cell types in the amygdala. Anderson's group, led by postdoctoral fellow Wulf Haubensak, found its marker in a gene that encodes an enzyme known as protein kinase C-delta (PKCδ). PKCδ is expressed in about half the neurons within a subdivision of the amygdala's central nucleus, the part of the amygdala that controls fear output.

Along with fellow postdocs Prabhat Kunwar and Haijiang Cai, Haubensak was able to fluorescently tag neurons in which the protein kinase is expressed; this allowed the researchers to map the connections of these neurons, as well as to monitor and manipulate their electrical activity.

The studies, Anderson says, "revealed that PKCδ+ neurons form one end of a seesaw, by making connections with another population of neurons in the central nucleus that do not express the enzyme, which are called PKCδ− neurons." They also showed that the kinase-positive neurons inhibit outflow from the amygdalaproving that they act as the end of the seesaw that rests on the garden hose.

Still, a key question remained: What happens to the seesaw during exposure to a fear-eliciting signal? Anderson and his colleagues hypothesized that the fear signal would push down on the opposite end of the seesaw from the one formed by the PKCδ+ neurons, removing the crimp from the garden hose and allowing the fear signal to flow. But how to test this idea?

Enter neurophysiologist Andreas Lthi and his student Stephane Ciocchi, from the Friedrich Miescher Institute in Basel, Switzerland. In work done independently from that of the Anderson lab, Lthi and Ciocchi had managed to record electrical signals from the amyg
'/>"/>

Contact: Jon Weiner
jrweiner@caltech.edu
626-395-3226
California Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. NIH awards $11.5 million for new Caltech-led membrane-protein center
2. Caltech chemists develop simple technique to visualize atomic-scale structures
3. Fruit flies use horizontal landmarks for altitude control, says Caltech research team
4. Caltech: Gain and loss in optimistic versus pessimistic brains
5. Caltech biologists discover how T cells make a commitment
6. East-African human ancestors lived in hot environments, says Caltech-led team
7. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
8. Caltech and UCSD scientists establish leech as model for study of reproductive behavior
9. Caltech receives more than $33 million from American Recovery and Reinvestment Act
10. Caltech researchers presenting at AAAS Meeting
11. Caltech researchers obtain first brain recordings from behaving fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... touch a hot oven, you rapidly pull your hand ... in sensing and responding to such painful stimuli, they ... researchers have made a surprising discovery about the role ... and have built a structural model of the molecule. ... , may help direct new strategies to treat pain ...
(Date:9/1/2014)... amount of research shows an association between TV viewing ... Now, a new Cornell University study points out that ... lead people to eat twice as much as other ... movie while snacking your mouth will see more action ... new article just published in the Journal of ...
(Date:9/1/2014)... quality of the U.S. diet showed some modest improvement ... a reduction in the consumption of unhealthy trans fats, ... the rich and the poor. , , An unhealthy ... some cancers. Eating a healthy diet is an important ... Evaluating population trends in diet quality is important because ...
Breaking Biology News(10 mins):Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3Can action movies make you fat? 2Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3
... and Washington DC (July 27, 2009) According to a ... Making , a large-scale, covert anthrax attack on a ... extremely effective public health response, primarily because of expected ... to it. The article "Predicting Hospital Surge after ...
... overall nation-wide estimate of the tiger population brought a ... by the Nepal Government,s Department of National Parks and ... 194) breeding tigers in the wild within the ... estimate was jointly implemented by the DNPWC, Department of ...
... Atrophy is the second-leading cause of infant mortality in the ... Iowa State University,s College of Veterinary Medicine, would like to ... slide off the list altogether. , Most Spinal Muscular Atrophy ... or deleted gene called Survival Motor Neuron 1 (SMN1) that ...
Cached Biology News:Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making 2121 breeding tigers estimated to be found in Nepal 2ISU researchers find possible treatment for spinal muscular atrophy 2
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Due to a ... last week, the Adult Stem Cell Technology Center, LLC ( ... support stem cell therapy research that might benefit ALS patients. ... cells for new stem cell technologies and therapeutic applications, FRC ... Ice Bucket Challenge donors who wish not to support ...
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... 28, 2014 “This kit has an improved ... from 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin ... benefit to plant owners and USDA-GIPSA inspection agencies that have ... Testing can take place in a matter of minutes with ... plant test the feed and grain before accepting it, but ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... CORVALLIS, Ore. Inkjet printers, a low-cost technology that in ... soon offer similar benefits for the future of solar energy. ... for the first time to create successful "CIGS" solar devices ... by 90 percent and will significantly lower the cost of ...
... HumanTouch, LLC welcomes David Meyer to our team as the ... tasked with assisting the executive leadership in building upon the ... health Information technology (IT) experience and expertise HumanTouch has been ... Senior Executive with more than 20 years of diverse experience ...
... ANGELES, June 28, 2011 Genesis Biopharma, Inc. ... therapies, is holding a conference call with the ... Noon Eastern (9:00 a.m. Pacific).  The Company,s Chairman ... provide an update on the business, and discuss ...
Cached Biology Technology:Inkjet printing could change the face of solar energy industry 2HumanTouch Welcomes David Meyer as Vice President of HumanTouch's new Health Solutions Division 2Genesis Biopharma Conference Call and Webcast Reminder 2
Request Info...
Anti-ZFP200 Family: Zinc Finger Peptide Sequence: CGKSFNHKTNLNKHER...
Donor feline serum and plasma...
Collected from sexually mature, mixed sex, mixed breed cats. Physiochemical constituents are measured to ensure lot-to-lot consistency....
Biology Products: