Navigation Links
Caltech scientists describe the delicate balance in the brain that controls fear
Date:11/10/2010

r-based psychiatric illnesses like post-traumatic stress disorder, phobias, or anxiety disorders."

The key to understanding this delicate mechanism, Anderson says, was in uncovering "markers"genes that would identify and allow for the scientists to discriminate between the different neuronal cell types in the amygdala. Anderson's group, led by postdoctoral fellow Wulf Haubensak, found its marker in a gene that encodes an enzyme known as protein kinase C-delta (PKCδ). PKCδ is expressed in about half the neurons within a subdivision of the amygdala's central nucleus, the part of the amygdala that controls fear output.

Along with fellow postdocs Prabhat Kunwar and Haijiang Cai, Haubensak was able to fluorescently tag neurons in which the protein kinase is expressed; this allowed the researchers to map the connections of these neurons, as well as to monitor and manipulate their electrical activity.

The studies, Anderson says, "revealed that PKCδ+ neurons form one end of a seesaw, by making connections with another population of neurons in the central nucleus that do not express the enzyme, which are called PKCδ− neurons." They also showed that the kinase-positive neurons inhibit outflow from the amygdalaproving that they act as the end of the seesaw that rests on the garden hose.

Still, a key question remained: What happens to the seesaw during exposure to a fear-eliciting signal? Anderson and his colleagues hypothesized that the fear signal would push down on the opposite end of the seesaw from the one formed by the PKCδ+ neurons, removing the crimp from the garden hose and allowing the fear signal to flow. But how to test this idea?

Enter neurophysiologist Andreas Lthi and his student Stephane Ciocchi, from the Friedrich Miescher Institute in Basel, Switzerland. In work done independently from that of the Anderson lab, Lthi and Ciocchi had managed to record electrical signals from the amyg
'/>"/>

Contact: Jon Weiner
jrweiner@caltech.edu
626-395-3226
California Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. NIH awards $11.5 million for new Caltech-led membrane-protein center
2. Caltech chemists develop simple technique to visualize atomic-scale structures
3. Fruit flies use horizontal landmarks for altitude control, says Caltech research team
4. Caltech: Gain and loss in optimistic versus pessimistic brains
5. Caltech biologists discover how T cells make a commitment
6. East-African human ancestors lived in hot environments, says Caltech-led team
7. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
8. Caltech and UCSD scientists establish leech as model for study of reproductive behavior
9. Caltech receives more than $33 million from American Recovery and Reinvestment Act
10. Caltech researchers presenting at AAAS Meeting
11. Caltech researchers obtain first brain recordings from behaving fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... of Warwick research finds , Gamblers show the ... new research has shown. , Researchers, led by Dr ... Psychology, conducted tests that found that both human gamblers ... high-value than low-value rewards. , Published in Biology ... show the important role that memories of previous biggest ...
(Date:8/26/2014)... developed algorithms to identify weak spots in tendons, muscles ... which needs to be refined before it is used ... and tiny injuries in the body,s tissues long before ... Aug. 27 in the Journal of the Royal ... of the physical and life sciences. , "Tendons are ...
(Date:8/26/2014)... of Warwick have provided the first evidence that ... linked to early signs of dementia. , Published ... that the absence of the protein MK2/3 promotes ... nervous system. These changes were shown to have ... including restricted learning and memory formation capabilities. , ...
Breaking Biology News(10 mins):Gamblers are greedy bird-brains, University of Warwick research finds 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Lack of naturally occuring protein linked to dementia 2
... Europe,s first personalized treatment for lung cancer heralds the ... that will demand significant changes to the way cancer ... said today at the 2nd European Lung Cancer Conference ... Medical University of Vienna said that personalized therapy, in ...
... first trial of an important new combination therapy of ... in lung cancer has delivered promising results, French researchers ... The results of the Phase I trial suggest ... well-enough tolerated to allow it to be administered at ...
... allows precise targeting of radiotherapy using real-time X-ray images has ... administered to lung and liver cancers while minimizing harm to ... Cancer Conference. "With this study we show that it ... that can give information at any time before or during ...
Cached Biology News:Making personalized lung cancer therapy a reality in Europe 2First trial of pemetrexed with radiation and chemo in lung cancer shows promising results 2
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces ... available in its catalogue: Global ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About ... that are readily decomposed by the action ... non-degradable packaging in terms of raw materials, ...
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... of the "Global Lactic Acid  (Biodegradable Polymer, ... - Trends & Forecasts to 2019" report ... the simplest hydroxyl-carboxylic acid with an asymmetrical carbon ... in the biodegradable polymer, food and beverage, personal ...
(Date:8/27/2014)... 2014 Reportbuyer.com has added a new ... - A Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... A similar amount of hype currently surrounds ... microelectronics to water treatment, but is graphene the ... the Graphene Opportunity Report, authored by Tim ...
(Date:8/27/2014)... JUNCTION, N.J. , Aug. 27, 2014 ... innovative drug delivery technologies, today announced that it has ... Jersey Business & Industry Association,s 2014 Awards for ... were selected by an independent panel of judges from ... company volunteers. Award winners will be honored at a ...
Breaking Biology Technology:Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2
... the Wisconsin Technology Council have released a report detailing ... the difficulties that still need to be addressed to ... ,Wisconsin Technology Council President Tom Still pointed out ... have lost 10 to 15 percent of their technology ...
... study reported in the June 2005 issue of ... predominant. But many companies, even in people businesses, ... need to excel. While organizations have perfected sophisticated ... production and flow of goods and services, their ...
... optimistic that his bill requiring notification of electronic ... year. , ,Senate Bill 164, co-authored by ... require companies that keep personal data on customers ... data is obtained by unauthorized parties. Kanavas said ...
Cached Biology Technology:Report: Wisconsin still lags in college degrees held by workforce, leads elsewhere 2Report: Wisconsin still lags in college degrees held by workforce, leads elsewhere 3Four steps to making talent management a core competence 2Four steps to making talent management a core competence 3Four steps to making talent management a core competence 4Kanavas thinks personal ID theft bill will pass this year 2
... Pipette Tracker is an automated solution ... calibration and performance testing for all pipettes ... directly from any balance Supports ... ISO 8655, DIN 12650, ISO 9000, NCCLS ...
... polypeptide hormones which belong to the ... TGF- superfamily is a large group ... many aspects of development, reproductive function ... incude TGF-s, bone morphogenetic proteins, growth ...
... polypeptide hormones which belong to the ... TGF- superfamily is a large group ... many aspects of development, reproductive function ... incude TGF-s, bone morphogenetic proteins, growth ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
Biology Products: