Navigation Links
Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
Date:8/29/2008

PASADENA, Calif.--Scientists at the California Institute of Technology (Caltech) have developed a simple process for mass producing molecular tubes of identical--and precisely programmable--circumferences. The technological feat may allow the use of the molecular tubes in a number of nanotechnology applications.

The molecular tubes are composed of wound-up strands of DNA. DNA has been considered an ideal construction material for self-assembling molecular structures and devices because two complementary DNA strands can automatically recognize and bind with each other. DNA has been used to form rigid building blocks, known as tiles, and these tiles can further assemble into extended lattice structures, including tubes. However, it has been difficult to control the diameters of such tubes.

Peng Yin, a senior postdoctoral scholar in bioengineering and computer science at Caltech's Center for Biological Circuit Design, along with his colleagues has designed a series of flexible, single-stranded DNA molecules, called single-stranded DNA tiles. Each single-stranded tile is exactly 42 bases long and contains four modular binding sites. By pairing up the complementary binding sites, these single-stranded tiles bind with each other in a particular orientation like Lego pieces snapped together, forming a tube composed of parallel DNA helices.

The circumference of the resulting tube is determined by the number of different 42-base pieces used in its construction. For example, four pieces create a tube with a circumference of 12 billionths of a meter (or 12 nanometers); five pieces, a 15-nanometer-circumference tube; and six pieces, an 18-nanometer tube.

"We are not the first to make DNA tubes with controlled circumferences. However, compared with previous approaches, our method is distinctively simple and modular," says Yin. The simplicity and modularity of their approach permits the description of the tube design using a simple graphical abstraction system developed earlier this year in the laboratory of Niles Pierce, associate professor_of applied and computational mathematics and bioengineering at Caltech.

Just as a variety of wood sizes are used in construction projects--two by four inches for framing walls, two by eight inches for roof rafters, or four by four inches for fence posts--having nanotubes of various, precisely controlled sizes provides their user with more options. In addition, nanotubes of different sizes have varying mechanical properties; for example, tubes with a smaller diameter are more flexible and tubes with a larger diameter are more rigid. The nanotubes might eventually serve as templates for manufacturing nanowires with controlled diameters; the diameters of electron-conducting nanowires would help determine the electronic properties of the devices they are used to construct.

"The simplicity of the single-stranded tile approach promises to enable us to design ever more complex self-assembling molecular systems. The work is simultaneously elegant and useful," says Erik Winfree, associate professor of computer science, computation and neural systems, and bioengineering at Caltech. Winfree's laboratory was the primary host of Yin's research at Caltech.


'/>"/>

Contact: Kathy Svitil
ksvitil@caltech.edu
626-395-8022
California Institute of Technology
Source:Eurekalert

Related biology news :

1. Caltech researchers awarded $10M for molecular programming project
2. Caltech engineers build mini drug-producing biofactories in yeast
3. Caltech neurobiologists discover individuals who hear movement
4. Caltech scientists awarded $20 million to Power the Planet
5. Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes
6. UNC, Caltech research finds further evidence for genetic contribution to autism
7. Indiana U researchers launch social networking and research management tool for scientists
8. CSHL scientists identify new drug target against virulent type of breast cancer
9. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
10. NYU scientists identify critical protein complex in formation of cell cilia
11. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... 2016 http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ... --> DERMALOG, le leader de ... lecteurs d,empreintes digitales pour l,enregistrement des réfugiés en ... pour produire des cartes d,identité aux réfugiés. DERMALOG ...
(Date:3/11/2016)... -- --> --> ... Market by Technology (Pattern Recognition), by Component (Hardware, Software, ... (On-Premises and Cloud), by Industry Vertical and by Region ... global market is expected to grow from USD 12.49 ... at a CAGR of 19.1%. , ...
(Date:3/10/2016)... Pa. , March 10, 2016   Unisys Corporation ... Customs and Border Protection (CBP) is testing its biometric ... San Diego to help identify certain non-U.S. ... . The test, designed to help determine the efficiency ... environment, began in February and will run until May 2016. ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... May 24, 2016 , ... Cell ... injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded ... healing and tissue regeneration. , The novel method, developed by WPI faculty members ...
(Date:5/23/2016)... ... , ... The need for blood donations in South Texas and across the nation is growing. ... Tissue Center, blood donations are on the decline. In fact, donations across the country are ... in South Texas in the last four years alone. , There is no substitute for ...
(Date:5/23/2016)... and LONDON , May 23, 2016 ... Could See Frontage Boost Efficiency by 40% - Frontage ... - Frontage Enforce Quality, Compliance and Traceability Within the Bioanalytical ... with labs in the United States and ... to be deployed across its laboratory facilities. In addition to ...
(Date:5/20/2016)... ... , ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ., is ... 100 of their own patients with the VetStem Cell Therapy. Each of these veterinarians ... their patients. , The veterinarians are Dr Ross Rich former owner of Cave ...
Breaking Biology Technology: