Navigation Links
Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
Date:8/29/2008

PASADENA, Calif.--Scientists at the California Institute of Technology (Caltech) have developed a simple process for mass producing molecular tubes of identical--and precisely programmable--circumferences. The technological feat may allow the use of the molecular tubes in a number of nanotechnology applications.

The molecular tubes are composed of wound-up strands of DNA. DNA has been considered an ideal construction material for self-assembling molecular structures and devices because two complementary DNA strands can automatically recognize and bind with each other. DNA has been used to form rigid building blocks, known as tiles, and these tiles can further assemble into extended lattice structures, including tubes. However, it has been difficult to control the diameters of such tubes.

Peng Yin, a senior postdoctoral scholar in bioengineering and computer science at Caltech's Center for Biological Circuit Design, along with his colleagues has designed a series of flexible, single-stranded DNA molecules, called single-stranded DNA tiles. Each single-stranded tile is exactly 42 bases long and contains four modular binding sites. By pairing up the complementary binding sites, these single-stranded tiles bind with each other in a particular orientation like Lego pieces snapped together, forming a tube composed of parallel DNA helices.

The circumference of the resulting tube is determined by the number of different 42-base pieces used in its construction. For example, four pieces create a tube with a circumference of 12 billionths of a meter (or 12 nanometers); five pieces, a 15-nanometer-circumference tube; and six pieces, an 18-nanometer tube.

"We are not the first to make DNA tubes with controlled circumferences. However, compared with previous approaches, our method is distinctively simple and modular," says Yin. The simplicity and modularity of their approach permits the description of the tube design using a simple grap
'/>"/>

Contact: Kathy Svitil
ksvitil@caltech.edu
626-395-8022
California Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Caltech researchers awarded $10M for molecular programming project
2. Caltech engineers build mini drug-producing biofactories in yeast
3. Caltech neurobiologists discover individuals who hear movement
4. Caltech scientists awarded $20 million to Power the Planet
5. Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes
6. UNC, Caltech research finds further evidence for genetic contribution to autism
7. Indiana U researchers launch social networking and research management tool for scientists
8. CSHL scientists identify new drug target against virulent type of breast cancer
9. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
10. NYU scientists identify critical protein complex in formation of cell cilia
11. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ...  report to their offering. One ... in technology. With continuous advances in technology, it ... latest standard that meets the needs and expectations ...
(Date:12/10/2014)... RALEIGH, N.C. , Dec. 9, 2014  Valencell, ... announced it is seeing a staggering demand from its ... demand, the Company revealed, is not solely coming from ... industries as well. "A wearable is only ... a result, accuracy is the ultimate driver in long-term ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased ... boosted investments in new testing and inspection technologies. ... given rise to a range of innovative test ... requirements of Generation Y, which is generally more ... a result, product development strategies of test equipment ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... University of Oklahoma Health Sciences Center have shown the first ... pressure. The results, which appear this month in the journal ... and how we might live longer. Persistent hypertension, or ... attack, heart failure, arterial aneurysm and is the leading cause ...
... CLEVELAND August 19, 2009 The Case Western Reserve University ... the National Institute of Biomedical Imaging and Bioengineering, a division ... Case Center for Synchrotron Biosciences. The center, to ... scientific community to support the study of the structure and ...
... American Society for Microbiology (ASM) ICAAC Young Investigator ... Assistant Professor, Vaccine and Infectious Diseases Institute, Fred ... of Allergy and Infectious Diseases, University of Washington, ... award recognizes early career scientists for research excellence ...
Cached Biology News:Anti-aging gene linked to high blood pressure 2Case Western Reserve University receives $4M from the NIBIB 2
(Date:12/17/2014)... December 16, 2014 “Never say, ... Philipps- Universität Marburg’s Department of Physics, advises young ... the newly released SPIE Women in Optics ... too shy to ask questions.” , In the ... and mathematics) occupations ranging from university professor and ...
(Date:12/17/2014)... Dallas, Texas (PRWEB) December 17, 2014 ... research on Global Quartz Tubing industry. For an ... information, definition, classification, application, industry chain structure, industry ... domestic quartz tubing industry has witnessed ... through a number of acquisitions. This report mentions ...
(Date:12/17/2014)... Dec. 16, 2014  Vermillion, Inc. (NASDAQ: ... disease, today announced the next step in its expanded ... solutions provider with the naming of current Chief Operating ... Executive Officer, while current Chairman of the Board and ... as Chairman. These changes are effective January 1, 2015. ...
(Date:12/17/2014)... , Dec. 17, 2014   Synageva BioPharma ... company developing therapeutic products for rare disorders, announced today ... being held in San Francisco, CA. ... and Chief Executive Officer, will present on Monday, January ... The presentation will be webcast live and may be ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... Fibrocell Science, Inc. (OTC Bulletin Board: FCSC) announced today ... U.S. Food and Drug Administration (FDA) related to the Biologics ... the treatment of moderate to severe nasolabial fold wrinkles in ... Center for Biologics Evaluation and Research (CBER) when the review ...
... , ANNAPOLIS, Md., Dec. 21 PharmAthene, Inc. (NYSE Amex: ... biological and chemical threats, today announced the appointment of Jeffrey ... Board to eight members. , Dr. Runge is a ... in business risk management, homeland security and homeland defense. ...
... , BOTHELL, WA and VANCOUVER, ... OGXI ) announced today that the Company will host a ... 21, 2009. , A live webcast will be available through ... http://ir.oncogenex.com . Alternatively, you may access the live conference ...
Cached Biology Technology:Fibrocell Science, Inc. Receives FDA Complete Response Letter Regarding azficel-T for Wrinkles 2PharmAthene Appoints Jeffrey W. Runge, M.D. to the Company's Board of Directors 2PharmAthene Appoints Jeffrey W. Runge, M.D. to the Company's Board of Directors 3OncoGenex Pharmaceuticals to Host Investor Conference Call at 8:30 a.m. ET, December 21, 2009 2
Without sodium bicarbonate. Sterile, Cell culture tested...
... Endogens Bovine IFNγ ELISPOT (enzyme-lined immunospot) ... the single cell level. A spot forms ... bound, is counted (either using a dissection ... compared to the number of cells added ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
... microarray data using Asuragens bioinformatics expertise. We ... to extensive data analysis using the most ... in combination with the Gene Expression Profiling ... ,Normalization and basic statistical analysis including publication ...
Biology Products: