Navigation Links
Caltech researchers show efficacy of gene therapy in mouse models of Huntington's disease
Date:10/30/2009

Pasadena, Calif.Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models.

"Gene therapy in these models successfully attenuated the symptoms of Huntington's disease and increased life span," notes Paul Patterson, the Anne P. and Benjamin F. Biaggini Professor of Biological Sciences.

Patterson is the senior investigator on the study, which was published in the October 28 issue of the Journal of Neuroscience.

Huntington's disease is a neurodegenerative disorder with a genetic basis. The disorder has its roots in a mutation in a protein called huntingtin, or Htt. (The gene itself is also referred to as the huntingtin gene.)

All versions of the Htt gene have repeats of a particular trio of nucleotidesspecifically, C, A, and G, which together code for the amino acid glutamine. In most people, that trio is repeated between 10 and 35 times. But in people who develop Huntington's disease, that genetic stutter goes on and on; they will have anywhere between 36 to upwards of 120 repeats.

The result of all these repeats? An abnormally long version of the Htt protein, which gets chopped up into smaller, toxic pieces and accumulates in nerve cells, debilitating them.

Enter Patterson group members Amber Southwell and Jan Ko, who began to look at the efficacy of two different intrabodies that had been shown, in cell cultures and fruit-fly models, to reduce the accumulation of toxic Htt protein. To see whether those effects would hold true in mammalian systems as well, the team tested the intrabodies in a series of five different mouse models of Huntington's.

One of the two intrabodies had some negative results, actually increasing Huntington's-related mortality in one model.

But the other intra
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Caltech scientists create robot surrogate for blind persons in testing visual prostheses
2. Caltech scientists get detailed glimpse of chemoreceptor architecture in bacterial cells
3. Caltech neuroscientists find brain region responsible for our sense of personal space
4. Caltech researchers explore how cells reconcile mixed messages in decisions about growth
5. Caltech scientists reveal how neuronal activity is timed in brains memory-making circuits
6. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
7. Caltech scientists control complex nucleation processes using DNA origami seeds
8. Caltech researchers train computers to analyze fruit-fly behavior
9. Caltech and UCSD researchers shed light on how proteins find their shapes
10. Caltech researchers help unlock the secrets of gene regulatory networks
11. Caltech researchers get first look at how groups of cells coordinate their movements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... knowledge regarding Ebola is critical and pertinent for practicing ... global outbreak and epidemic. The Journal, Disaster Medicine ... issue, Ebola Virus and Public Health, to surround the ... this critical societal moment. , On October 17, ... Clinicians . The primer was prepared by Dr. Eric ...
(Date:10/17/2014)... German . ... When treating overdoses, doctors are often limited to supportive therapy ... is a combination of drugs involved. So what can be ... grandmother,s pills? ETH professor Jean-Christophe Leroux from the Institute of ... to this question. "The task was to develop an agent ...
(Date:10/16/2014)... synthesis of recent research findings to inform their management ... states. , The Ecology and Management of Moist ... of the Relevant Biophysical Science and Implications for Future ... U.S. Forest Service,s Pacific Northwest Research Station, is a ... synthesis of the large body of scientific information on ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3New report synthesizes best available science on management of moist mixed-conifer forests 2
... Polycyclic Aromatic Compounds (PACs) on terrestrial and benthic invertebrates ... sediment contamination. Effects are assessed exposing the organisms to ... cases this results in highly predictable effects on development ... that the effects of prolonged exposure can be very ...
... researchers under the leadership of Vici-winner Merel Kindt has ... in human volunteers by administering the beta-blocker propranolol. Interestingly, ... of time. Top journal Nature Neuroscience published ... recently, it was assumed that the fear memory could ...
... well crickets adapt to rising temperatures may provide clues ... UCF scientist Wade Winterhalter landed an $860,000 grant ... study that fuses global warming models with a biological ... ground cricket, also known as the Allonemobius socius. ...
Cached Biology News:Soil and sediment contamination assessment more accurate 2An end to fear 2Crickets may predict human survivability during global warming 2
(Date:10/25/2014)... 24, 2014 Oramed Pharmaceuticals Inc. ... focused on the development of oral drug delivery systems, ... will present at FireRock Capital,s Micro-Cap Conference. ... Conference ,Date: Tuesday, October 28, 2014 ,Time: 9:15am EST ... York City , About The ...
(Date:10/25/2014)... 2014 ... announced the addition of the  "The Global ... 2-D Nanomaterials "  report to their offering.  ... and graphene are the strongest, lightest and ... a performance-per-weight greater than any other material. ...
(Date:10/22/2014)... The North American crystal oscillator market report ... analysis and forecast of revenue. This market was valued ... reach $623.6 million by 2018, at a CAGR of ... TOC of the North American crystal oscillator market report, ... This also provides a glimpse of the segmentation of ...
(Date:10/22/2014)... Al Khaimah, UAE (PRWEB) October 22, 2014 ... game-changing life science and healthcare projects, announces the addition ... MRCGP DRCOG DCH to its advisory team. Dr. Siddiqui ... advisory team. , A graduate of University ... Siddiqui was subsequently degreed in medicine in 2001. With ...
Breaking Biology Technology:Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2
... Mich., April 25 The Fraunhofer Center ... the BU,Center for Nanoscience and Nanobiotechnology hosted ... for a tour of their world class,facilities ... The intensive tour included demonstrations of ...
... April 25 /Xinhua-PRNewswire-FirstCall/ -- China Yingxia,International, Inc. ... "the,Company"), a leading provider in the nutraceutical ... of organic nutritional food,products, supplements, and personal ... ("PRC"), today announced that it has formally ...
... BASINGSTOKE, England and PHILADELPHIA, April 25 /PRNewswire-FirstCall/,-- Shire plc (LSE: ... the three months to March,31, 2008., Q1 2008 ... - New product sales(1) $216m, 34% of product sales ... - US GAAP Operating income up 15% to $163m ...
Cached Biology Technology:Fraunhofer and Boston University Hosted Prestigious SME Tour 2China Yingxia International, Inc. Acquires Grocery Chain and Online Distribution Network 2China Yingxia International, Inc. Acquires Grocery Chain and Online Distribution Network 3Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 2Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 3Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 4Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 5Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 6Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 7Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 8Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 9Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 10Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 11Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 12Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 13Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 14Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 15Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 16Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 17Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 18Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 19Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 20Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 21Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 22Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 23Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 24Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 25Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 26Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 27Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 28Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 29Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 30Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 31Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 32Following a Good Start to the Year Shire Reaffirms Full Year 2008 Financial Guidance 33
... to the Salmonella Common Structural Antigens (CSA) ... serum pool of goats immunized with different ... broadly reactive to Salmonella and recognizes all ... excellent specificity for Group B and D ...
This antibody detects ubiquitinated proteins on SDS-PAGE immunoblots. It does not detect free ubiquitin....
... FastPrep System combines 2 products into 1:, ... A molecular isolation kit , ,The ... machine and Qbiogene/BIO101 System Matrix and Isolation ... individual micro tubes eliminating the use of ...
Abgene's ALTO-8 is the first automated decapper/capper for Abgene Twist-Lock tubes....
Biology Products: