Navigation Links
Caltech researchers increase the potency of HIV-battling proteins
Date:7/29/2011

PASADENA, Calif.If one is good, two can sometimes be better. Researchers at the California Institute of Technology (Caltech) have certainly found this to be the case when it comes to a small HIV-fighting protein.

The protein, called cyanovirin-N (CV-N), is produced by a type of blue-green algae and has gained attention for its ability to ward off several diseases caused by viruses, including HIV and influenza. Now Caltech researchers have found that a relatively simple engineering technique can boost the protein's battling prowess.

"By linking two cyanovirins, we were able to make significantly more potent HIV-fighting molecules," says Jennifer Keeffe, a staff scientist at Caltech and first author of a new paper describing the study in the Proceedings of the National Academy of Sciences (PNAS). "One of our linked molecules was 18 times more effective at preventing infection than the naturally occurring, single protein."

The team's linked pairs, or dimers, were able to neutralize all 33 subtypes of HIV that they were tested against. The researchers also found the most successful dimer to be similar or more potent than seven well-studied anti-HIV antibodies that are known to be broadly neutralizing.

CV-N binds well to certain carbohydrates, such as the kind found in high quantities connected to the proteins on the envelope that surrounds the HIV virus. Once attached, CV-N prevents a virus from infecting cells, although the mechanism by which it accomplishes this is not well understood.

What is known is that each CV-N protein has two binding sites where it can bind to a carbohydrate and that both sites are needed to neutralize HIV.

Once the Caltech researchers had linked two CV-Ns together, they wanted to know if the enhanced ability of their engineered dimers to ward off HIV was related to the availability of additional binding sites. So they engineered another version of the dimersthis time with one o
'/>"/>

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Think healthy, eat healthy: Caltech scientists show link between attention and self-control
2. Caltech researchers create the first artificial neural network out of DNA
3. Caltech scientist awarded $5 million grant for plant research
4. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
5. 2011 HFSP Nakasone Award for Michael Elowitz of Caltech
6. Young Caltech engineers recognized for innovative work in disease diagnostic technologies
7. Tip sheet: Caltech researchers presenting at AAAS
8. Caltech-led team creates damage-tolerant metallic glass
9. Caltech scientists describe the delicate balance in the brain that controls fear
10. NIH awards $11.5 million for new Caltech-led membrane-protein center
11. Caltech chemists develop simple technique to visualize atomic-scale structures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... , June 24, 2015 Biometry ... with emerging biometric password solution one face in. ... one face in, entering the ... ground-breaking and affordable multifactor-authentication biometric answer to the ... technology, provided in partnership with KeyLemon, one face ...
(Date:6/18/2015)... , June 18, 2015 This report analyzes ... by the following Product Segments, which includes Immunoassay Analyzers ... Immunoassay Systems, Radio Immunoassay Systems, and Nephelometric Immunoassay Systems. ... Canada , Japan ... , Latin America , and ...
(Date:6/17/2015)... PALM BEACH GARDENS, Fla. , June 17, ... identity management solutions, today announced that its U.are.U ... by Togo,s Eateries, Inc., ... based fast casual sandwich chain, to increase security, ... (POS). The Crossmatch fingerprint readers enable instant, non-repudiable identity ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... of microbes living underground could determine the amount of carbon ... a study published online this week in Nature Geoscience ... the Yale School of Forestry & Environmental Studies found that ... over time at converting carbon in soil into carbon dioxide, ...
... Mass. Everyone wants to live in the nicest possible ... biologists at Tufts University,s School of Arts and Sciences ... may locate new and improved housing using previously unknown ... lab experiments and computer models to uncover some surprising ...
... Tampa, FL (April 23, 2010) Moffitt Cancer Center ... first test developed for selecting chemotherapy for Non Small ... Americans are diagnosed with lung cancer. The ERCC1 ... to cisplatin-based chemotherapy. The correlation between ERCC1 ...
Cached Biology News:Soil microbes produce less atmospheric CO2 than expected with climate warming 2Social networking helps hermit crabs find homes 2Social networking helps hermit crabs find homes 3Moffitt Cancer Center: Growing interest in prognostic test for non-small cell lung cancer 2
(Date:7/3/2015)... July 3, 2015  Pomerantz LLP announces that a ... Inc. ("Puma" or the "Company")(NYSE: PBYI ) and ... United States District Court, Central District of ... behalf of a class consisting of all persons or ... and May 13, 2015 inclusive (the "Class Period").  This ...
(Date:7/2/2015)... Md. , July 2, 2015  Spherix Incorporated ... to the fostering and monetization of intellectual property, today ... of Spherix Incorporated v. Verizon Services Corp. et ... District Court for the Eastern District of ... on July 1, 2015 interpreting certain key claims in ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... It is ... injury (TBI) using single photon emission computed tomography (SPECT) according to researchers ... study, which examined over 20,000 brain scans and is believed to be the largest ...
(Date:7/1/2015)... AURORA, Colo. and BANGALORE, India ... a global genomic profiling company that uses next generation ... appointment of Scott A. Storrer as chief ... and CEO, he will be responsible for all strategy, ... Vijay Chandru , who has served as Strand,s chairman ...
Breaking Biology Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4Spherix Issues A Litigation Update 2Spherix Issues A Litigation Update 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
... way to protect us against otherwise deadly chemical attacks, such ... people dead and thousands more injured or with temporary vision ... version of a detoxifying enzyme produced naturally by our livers, ... Chemistry & Biology , a Cell Press publication. ...
... based on nanoimprinting techniques (NIL) is evolving at a rapid ... overcome in order to reach the market? How do we ... the industry? What are the tools needed for each product? ... tags to life science products were discussed by more than ...
...   On May 21-23, 2012, Diversity Alliance for ... mentor, and develop minority-, woman-, veteran/service-disabled-, HUBZone-, and ... annual networking conference and EXPO event.  Bret Michaels, ... address the conference held at the Renaissance Newark ...
Cached Biology Technology:Defending against chemical acts of terrorism 2Tackling the European market of nanoimprint lithography 2Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 2Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 3
Request Info...
...
... Rabbit polyclonal to Atrophin 1 ( Abpromise ... Antigen: Synthetic peptide conjugated to ... the C-terminus of Human Atrophin 1.(Note: the ... ab32861 .) Entrez ...
An excellent carbonyl-reactive FRET quencher paired with Trp or Tyr. Minimum Purity: 95%. Abs(max): ~350 nm; Em(max): none. Solvent System:DMSO or DMF....
Biology Products: