Navigation Links
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
Date:6/19/2009

e that inhibiting signal. The cells on the periphery of a cluster, on the other hand, get a relative whisper of an inhibitory signal; it doesn't take nearly as much growth factor to prompt those cells to divide.

Thus, it's possible to find a level of growth factor that will override the contact inhibition signal only for the peripheral cells, and then to find a second level that will allow division throughout the cluster. In other words, says Asthagiri, "You can tune the system; you can make the periphery grow more quickly relative to the rest of the area, or you can get the entire cluster to increase in size all at once."

"This is useful," he adds, "in thinking about how to engineer organs and tissues. I believe that this can become an important building block, a part of the tool set, that allows us to grow multicellular structuresand, ultimately, tissuesin specific, spatial ways."

And as for cancer? It's long been assumed that contact inhibition acts as a sort of switch that, when present, prevents tumor formation and, when absent, results in cell overgrowth and cancer. "Our findings support a more graded perspective of contact inhibition," the researchers write in the PNAS paper. Keeping in mind that cancer is often the result of an accumulation of genetic damage, they say, it seems likely that each "hit" to a cell's DNA might subtly lower the threshold at which EGF is capable of overriding contact inhibition to promote unbridled cell division and tumor growth.

"This tunability of the threshold amount of EGF," the researchers write, "would seem to be a fragility in cell cycle regulation that is exploited during cancer development."


'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Caltech scientists reveal how neuronal activity is timed in brains memory-making circuits
2. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
3. Caltech scientists control complex nucleation processes using DNA origami seeds
4. Caltech researchers train computers to analyze fruit-fly behavior
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Caltech researchers help unlock the secrets of gene regulatory networks
7. Caltech researchers get first look at how groups of cells coordinate their movements
8. Caltech scientists show function of helical band in heart
9. Caltech scientists develop barcode chip for cheap, fast blood tests
10. Celebrated UH researcher invited to Caltech as distinguished scholar
11. Caltech researchers get first 3-D glimpse of bacterial cell-wall architecture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
(Date:9/17/2014)... Researchers at UTSouthwestern Medical Center have found that ... E, called apoE3, helps repair the lining of blood ... get the benefit of this repair, putting them at ... we have identified one mechanism by which apoE3 promotes ... apoE4, is detrimental," said Dr. Philip Shaul , ...
(Date:9/17/2014)... As the United Kingdom forms a new crime unit ... an uproar last year over horse meat being passed ... a technique for detecting meat adulteration. They describe their ... in ACS, Journal of Agricultural and Food Chemistry ... fraud is a major global economic problem. But they ...
(Date:9/16/2014)... morbidity amongst women in Australia is increased by ... today (17 September) in BJOG: An International ... generally enjoy high standards of living; however, existing ... particular between indigenous and non indigenous Australians. , ... impact of socioeconomic position on severe maternal morbidities ...
Breaking Biology News(10 mins):Protein variant may boost cardiovascular risk by hindering blood vessel repair 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3
... L. Billiar, associate professor of biomedical engineering at Worcester ... to work at the National University of Ireland Galway ... who will be in Ireland for the 2009-10 academic ... faculty to be awarded a Fulbright Scholar grant. ...
... the oil tanker Exxon Valdez was exiting Alaska,s Prince William ... the night. What happened next is considered one of the ... spilled into the pristine Alaskan waters, eventually covering 11,000 square ... the amount of oil spilled in the Exxon Valdez accident. ...
... May 13, 2009 The Association for Molecular Pathology ... American Civil Liberties Union (ACLU) and the Public Patent ... two human genes associated with breast and ovarian cancer ... mutations along these two genes, known as BRCA1 and ...
Cached Biology News:WPI professor receives Fulbright Scholarship to work on tissue engineering in Ireland 2UCSB scientists document fate of huge oil slicks from seeps at coal oil point 2UCSB scientists document fate of huge oil slicks from seeps at coal oil point 3UCSB scientists document fate of huge oil slicks from seeps at coal oil point 4Association for Molecular Pathology joins ACLU to challenge gene patents 2
(Date:9/17/2014)... JH Technologies announces the grand opening ... JH Technologies, a leader in sales and support of ... partnership with Leica Microsystems into the Southern California market. ... will be featured at the grand opening slated for ... is located within the JH Technologies office’s at 18025 ...
(Date:9/17/2014)... September 17, 2014 Terracon Corporation has ... its TerraPure tank . This addition to the ... from FDA-compliant linear polyethylene and available in 125 or ... and ships in two weeks or less. , The ... benefits found in Terracon’s existing TerraPure tank line – ...
(Date:9/17/2014)... , Sept. 17, 2014 Alternative Fuels Americas, Inc. ... form a Special Purpose Vehicle in partnership with Jatro Greentech, ... agro energy company. The SPV shall be called AFAI Jatro ... AFAI as majority shareholder. The SPV shall pursue Jatropha planting ... particularly Ethiopia . "Although ...
(Date:9/17/2014)... RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... has been granted a patent by the United ... delivery system for delivering its "original" RNAi compounds ... treatment of diseases with an inflammatory component. Potential ...
Breaking Biology Technology:JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Terracon Introduces Pre-Engineered TerraPure® Tank for Ultrapure Water Applications 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4
... Senomyx, Inc. (Nasdaq: SNMX ), a leading company ... and develop novel flavor ingredients for the food, beverage, ... the Company,s President and Chief Operating Officer, will present ... p.m. Pacific Time (4:30 p.m. Eastern Time) during the ...
... ... a leading organization dedicated to pricing strategy and pricing research globally and Vendavo®, a ... the Vendavo,s Pricing Knowledge Series training programs are now eligible for credit in the ... ...
... Dr. scar Custance from the National Institute for Materials Science ... for Experimental Work in Nanotechnology for his research in atomic-scale ... lead to more effective catalysts for the production of hydrogen ... be awarded in January 2010 near Palo Alto, California along ...
Cached Biology Technology:SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE 2009 BIOCOM INVESTOR CONFERENCE 2Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 2Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 3Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 4Researcher honored for experimental work in nanotechnology 2
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... wall plates have low background fluorescence, ... Not treated (or medium binding) polystyrene ... binds biomolecules through passive interactions,• ... of large molecules, such as antibodies, ...
... The Model 1575 immunowash microplate washer, 100-240 ... that have flat-, U-, or V-bottom wells. ... vertical needle positions to an accuracy of ... and overflow washing. It can store up ...
... Incubator is a compact benchtop and ... microprocessor controller with a large display ... agitation speed. Air circulation inside to ... Temperature can be easily calibrated from ...
Biology Products: