Navigation Links
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
Date:6/19/2009

cells, they found that the cells have a threshold of sensitivity to EGF. If EGF levels dip below the threshold, contact inhibition takes hold and puts the brakes on cell division. But if EGF levels rise above the threshold, it overrides the effects of cell-cell contact and promotes cell division and tissue growth.

Both factors can potentially be manipulatedeither to raise or lower the levels of growth factor or, as Asthagiri and colleagues showed in their paper, to raise or lower the contact-inhibition threshold.

In other words, Asthagiri explains, the team's research showed that it's possible to tune the systemto make cells more or less able to respond to a certain level of EGF by "playing with the extent of the contact the cells have with their neighbors."

One way to do that is to crowd the cells. "For instance," he says, "if you take a large number of cells and force them into the same area in which only a few cells are normally found, the cells become somewhat deaf to the growth factors. In order to get these cells to divide, you really have to crank up the level of growth factors they're exposed to."

You can achieve a similar result, Asthagiri adds, by creating cells that overexpress a protein called E-cadherin, which is a tumor suppressor protein that promotes adhesion of one cell to another. "This makes the cells less willing to divide," he notes, "which means they need a higher level of growth factor before they will divide."

The relationships between these competing influences "are really striking when you let them play out" under the influence of cell geography, says Asthagirithat is, when the cells grow as a multicellular cluster. The reality is that not all cells in a cluster are exposed to the same amount of inhibition. For instance, the cells in the center of the grouppressed against other cells on all sideswill experience more contact, and will require a larger amount of growth factor if they are to overcom
'/>"/>

Contact: Lori Oliwenstein
lorio@caltech.edu
626-395-3631
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Caltech scientists reveal how neuronal activity is timed in brains memory-making circuits
2. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
3. Caltech scientists control complex nucleation processes using DNA origami seeds
4. Caltech researchers train computers to analyze fruit-fly behavior
5. Caltech and UCSD researchers shed light on how proteins find their shapes
6. Caltech researchers help unlock the secrets of gene regulatory networks
7. Caltech researchers get first look at how groups of cells coordinate their movements
8. Caltech scientists show function of helical band in heart
9. Caltech scientists develop barcode chip for cheap, fast blood tests
10. Celebrated UH researcher invited to Caltech as distinguished scholar
11. Caltech researchers get first 3-D glimpse of bacterial cell-wall architecture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
(Date:7/31/2015)... 31 juillet 2015 La 10e Conférence ... sera organisée par le BGI du 22 au ... en Chine. La conférence célèbre ... en 2006, l,ICG est devenue l,une des réunions ... des « omiques » et c,est aussi la plus dynamique, ...
(Date:7/31/2015)... Conn. , Jul. 31, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies such ... by introducing a common, uniform way to manage all ...
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that Huawei has selected ... solution for its stylish smartwatch. Huawei chose the ... reliability, low power and highly responsive human interface ... Huawei designers also required a classic round watch ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... ability to reduce cholesterol, but a research report appearing in ... Biology ( http://www.jleukbio.org ) shows that these same drugs ... lung damage resulting from severe abdominal sepsis and infection. ... knowledge about the complicated pathophysiology behind abdominal sepsis, but also ...
... When schools cut physical education programs so students can ... a golden opportunity to promote learning, according to research to ... (PAS) annual meeting in Denver. The study adds ... the body but also the mind. It also shows that ...
... disasters can affect children,s health in unique ways, both physically ... annual meeting at the Colorado Convention Center in Denver, Colo., ... will examine the toll of two recent disasters on children,s ... and the 2010 Gulf of Mexico oil spill. ...
Cached Biology News:Statins may stave off septic lung damage says new research study 2Movement + academics = success 2Pediatricians examine impact of environmental disasters on children's health 2
(Date:8/28/2015)... ... , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company continues ... Images such as the Fonz in a lab coat and Large Marge have been posted ... field. , FireflySci is proud to be the only cuvette manufacturer is the ...
(Date:8/27/2015)... - Portage Biotech Inc. ("Portage") (OTC Market: PTGEF, ... Company Limited (Biohaven), announced today that dosing has ... a glutamate modulating agent. Biohaven filed an investigational ... clearance from the U.S. Food and Drug Administration ... 54% equity interest in Biohaven, a private company. ...
(Date:8/27/2015)... Aug. 27, 2015 HUYA Bioscience International (HUYA) today ... the Japan Society of HTLV-1, held this week at ... purpose of the Society is to promote research on ... of medical technology and research related to these fields ... "HUYA is proud to support this prestigious conference," ...
(Date:8/27/2015)... Aug. 27, 2015 In response to ... UPS and The US Postal Service to no ... as ,select agents, by the CDC, Marken reaffirmed ... these sensitive shipments. Marken uses its ... trained and certified personnel to ensure the safe ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... Mich., Sept. 27 Neogen Corporation,(Nasdaq: NEOG ) ... quarter of,FY 2008, which ended Aug. 31, increased 25% ... a 3-for-2 stock split, net income per,share was $0.21 ... for the,same period in the prior year. First ...
... provides additional treatment option for asthma patients not fully ... ... NAPA, Calif., Sept. 27 Dey, L.P., an,affiliate of Merck ... (zileuton) extended-release tablets with its,marketing partner, Critical Therapeutics, Inc. (Nasdaq: ...
... Systems (NYSE: VAR ) and one of ... IGRT (image guided radiotherapy),training school, enabling hospitals across ... most precise radiotherapy technologies available to radiation,oncologists. ... the venue for,the first event of its kind, ...
Cached Biology Technology:Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 2Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 3Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 4Neogen Reports 25% Increase in Net Income, 13% Increase in Revenues 5Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 2Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 3First European IGRT School Takes Place for Radiotherapy Practitioners in UK 2First European IGRT School Takes Place for Radiotherapy Practitioners in UK 3
... benchtop ductless exhaust hood ventilates and ... indoor release of exhaust. Bonded charcoal ... 28" of vertical clearance (with access ... polypropylene spill tray; options include final ...
...
... These versatile enclosures are ... nitrogen or other process ... low-humidity environment. HEPA filtration, ... ionization modules also available, ...
... new Hummingbird has the ability to quickly and ... makes it a perfect candidate for inclusion in ... OCX interface supplied with all the Cartesian products ... Hummingbirds ability to copy plates in seconds ...
Biology Products: