Navigation Links
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
Date:6/2/2011

>

Their new logic gates are made from pieces of either short, single-stranded DNA or partially double-stranded DNA in which single strands stick out like tails from the DNA's double helix. The single-stranded DNA molecules act as input and output signals that interact with the partially double-stranded ones.

"The molecules are just floating around in solution, bumping into each other from time to time," Winfree explains. "Occasionally, an incoming strand with the right DNA sequence will zip itself up to one strand while simultaneously unzipping another, releasing it into solution and allowing it to react with yet another strand." Because the researchers can encode whatever DNA sequence they want, they have full control over this process. "You have this programmable interaction," he says.

Qian and Winfree made several circuits with their approach, but the largestcontaining 74 different DNA moleculescan compute the square root of any number up to 15 (technically speaking, any four-bit binary number) and round down the answer to the nearest integer. The researchers then monitor the concentrations of output molecules during the calculations to determine the answer. The calculation takes about 10 hours, so it won't replace your laptop anytime soon. But the purpose of these circuits isn't to compete with electronics; it's to give scientists logical control over biochemical processes.

Their circuits have several novel features, Qian says. Because reactions are never perfectthe molecules don't always bind properly, for instancethere's inherent noise in the system. This means the molecular signals are never entirely on or off, as would be the case for ideal binary logic. But the new logic gates are able to handle this noise by suppressing and amplifying signalsfor example, boosting a signal that's at 80 percent, or inhibiting one that's at 10 percent, resulting in signals that are either close to 100 percent present or nonexistent.

A
'/>"/>

Contact: Deborah Williams-Hedges
debwmh@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. 2011 HFSP Nakasone Award for Michael Elowitz of Caltech
2. Young Caltech engineers recognized for innovative work in disease diagnostic technologies
3. Tip sheet: Caltech researchers presenting at AAAS
4. Caltech-led team creates damage-tolerant metallic glass
5. Caltech scientists describe the delicate balance in the brain that controls fear
6. NIH awards $11.5 million for new Caltech-led membrane-protein center
7. Caltech chemists develop simple technique to visualize atomic-scale structures
8. Fruit flies use horizontal landmarks for altitude control, says Caltech research team
9. Caltech: Gain and loss in optimistic versus pessimistic brains
10. Caltech biologists discover how T cells make a commitment
11. East-African human ancestors lived in hot environments, says Caltech-led team
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
(Date:10/17/2014)... This news release is available in German . ... need millions of sperms every day in order to reproduce? ... questions are the topic of the latest issue of the ... 16th, 2014). The evolutionary biologist Steven Ramm from Bielefeld University ... nature, it is not unusual for a female to copulate ...
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
Breaking Biology News(10 mins):Sperm wars 2Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2
... Ariz. One of the great mysteries of life is how ... into something as complex as a living cell? For more ... steps on the road to life. Until recently, their focus has ... have been synthesized on the early Earth, or perhaps in space. ...
... Cladophora in the Great Lakes, including phosphorus-rich Lake Erie, ... onto the radar of scientists, including Mercyhurst University biologist Steven ... that incidences of avian botulism are linked to Cladophora ... pathogens have sparked renewed attention in the nuisance algae. ...
... than 70 humans and 200 Asian elephants every year. One ... moving the elephants into ranges away from humans, often into ... that include elephants raiding crops, breaking into homes and injuring ... to be published Dec. 7 in PLOS ONE ...
Cached Biology News:ASU researchers propose new way to look at the dawn of life 2ASU researchers propose new way to look at the dawn of life 3Grant furthers Mercyhurst research for human pathogens in Great Lakes 2Relocating elephants fails to decrease human-wildlife conflict 2
(Date:10/18/2014)... The Asian arthroscopic devices report defines and segments ... of revenue. The arthroscopic devices market in Asia is ... a CAGR of 6.5% from 2013 to 2018. , ... market, to get an idea of the in-depth analysis ... of arthroscopic devices market in the same region, and ...
(Date:10/18/2014)... NY (PRWEB) October 18, 2014 The ... healthy rate in the five years to 2014. The ... federal renewable energy tax credits that encouraged the use ... enacted renewable portfolio standards (RPSs), which require local utilities ... of their total energy portfolio. Increased campaigning for green ...
(Date:10/17/2014)... received a $451,781 Air Force Office of Scientific Research ... and nano-scale level that will provide clues for predicting ... and Aerospace Engineering, said the new technology and process ... of an aircraft,s wing., "We,ll be able to determine ... at it on this scale," Huang said. "Certain patterns ...
(Date:10/17/2014)... Bioquell, provider of germ-eliminating robots and ... around the world to decontaminate locations where Ebola-infected ... many places the hydrogen peroxide vapor technology is ... and at the National Institutes of Health (NIH) ... utilized to decontaminate patient rooms, equipment, and an ...
Breaking Biology Technology:The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3UT Arlington project to detect possible damages in aircraft parts early in process 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
... , DURHAM, N.C., Nov. 25 Research ... water purification system NanoPure(TM) developed from carbon nanotubes to ... Viswarup and other leaders in Hyderabad, India today. Initial ... confirmed that the majority of the drinking water available ...
... ON, Nov. 25 /PRNewswire/ - Cytochroma today announced the appointment ... Moldt will replace Mr. Ulrik Spork as the Novo A/S ... remains unchanged at six members. , "We are very pleased ... to benefiting from his experience and guidance as Cytochroma continues ...
... This release is available in German . ... RFID tags (Radio Frequency Identification) are increasingly finding their way ... or goods and identify them automatically by radio frequency. The ... the label. Smart labels can be affixed to goods under ...
Cached Biology Technology:North Carolina-based Cnanoz Unveils NanoPure(TM) to Government Leaders in Hyderabad, India 2Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2Intelligence inside metal components 2
Recombinant Feline IFN-alpha...
... ELISA Development kit contains the basic components ... to measure natural and recombinant canine Monocyte ... supernates and serum.1 Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Spastin (Sp 3G11/1)...
Biology Products: