Navigation Links
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
Date:6/2/2011

PASADENA, Calif.In many ways, life is like a computer. An organism's genome is the software that tells the cellular and molecular machinerythe hardwarewhat to do. But instead of electronic circuitry, life relies on biochemical circuitrycomplex networks of reactions and pathways that enable organisms to function. Now, researchers at the California Institute of Technology (Caltech) have built the most complex biochemical circuit ever created from scratch, made with DNA-based devices in a test tube that are analogous to the electronic transistors on a computer chip.

Engineering these circuits allows researchers to explore the principles of information processing in biological systems, and to design biochemical pathways with decision-making capabilities. Such circuits would give biochemists unprecedented control in designing chemical reactions for applications in biological and chemical engineering and industries. For example, in the future a synthetic biochemical circuit could be introduced into a clinical blood sample, detect the levels of a variety of molecules in the sample, and integrate that information into a diagnosis of the pathology.

"We're trying to borrow the ideas that have had huge success in the electronic world, such as abstract representations of computing operations, programming languages, and compilers, and apply them to the biomolecular world," says Lulu Qian, a senior postdoctoral scholar in bioengineering at Caltech and lead author on a paper published in the June 3 issue of the journal Science.

Along with Erik Winfree, Caltech professor of computer science, computation and neural systems, and bioengineering, Qian used a new kind of DNA-based component to build the largest artificial biochemical circuit ever made. Previous lab-made biochemical circuits were limited because they worked less reliably and predictably when scaled to larger sizes, Qian explains. The likely reason behind this limitation is that such ci
'/>"/>

Contact: Deborah Williams-Hedges
debwmh@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. 2011 HFSP Nakasone Award for Michael Elowitz of Caltech
2. Young Caltech engineers recognized for innovative work in disease diagnostic technologies
3. Tip sheet: Caltech researchers presenting at AAAS
4. Caltech-led team creates damage-tolerant metallic glass
5. Caltech scientists describe the delicate balance in the brain that controls fear
6. NIH awards $11.5 million for new Caltech-led membrane-protein center
7. Caltech chemists develop simple technique to visualize atomic-scale structures
8. Fruit flies use horizontal landmarks for altitude control, says Caltech research team
9. Caltech: Gain and loss in optimistic versus pessimistic brains
10. Caltech biologists discover how T cells make a commitment
11. East-African human ancestors lived in hot environments, says Caltech-led team
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
(Date:8/20/2014)... in this image of the Para and Mato Grosso ... likely intentionally set in order to deforest the land. ... of trees where the land is thereafter converted to ... forestland to farms, ranches, or urban use. The herringbone-patterned ... Amazon Rainforest in the middle of the image are ...
(Date:8/20/2014)... Research UK scientists have discovered that acral melanomas the ... Marley,s death are genetically distinct from other more common ... external) published in the journal Pigment Cell & Melanoma ... of the hands, soles of the feet, nail-beds and other ... of melanoma, it,s not caused by UV damage from the ...
(Date:8/20/2014)... Virginia Tech,s Wu Feng has built upon a National ... in the Cloud" program, and synergistically complemented it with ... the Air Force on "big computing" for mini-drones and ... Institutes of Health on "big data" for the life ... aspects from each grant, he was able to tell ...
Breaking Biology News(10 mins):Scientists learn more about rare skin cancer that killed Bob Marley 2The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4
... and Capital Health surgeon, well known for his pioneering ... has taken another important step in the fight against ... Dr. Koichi Tanaka and Dr. James Shapiro, along with ... 56-year-old woman's pancreas. Dr. Shinichi Masumoto then isolated the ...
... biologists have uncovered how the innate immune system in ... published as the cover study in the latest issue ... virus at multiple stages--by preventing the formation of viral ... could infect other cells in the brain. , "There ...
... imaging technique have shed light on the tiny movements of ... cooperate in a delicate choreography of steps, rather than engaging ... , "We discovered that two molecular motors -- dynein ... they want to move the same cargo in opposite directions," ...
Cached Biology News:World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics 2NYU study reveals how brain's immune system fights viral encephalitis 2Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows 2
(Date:8/20/2014)... -- Decision Resources Group finds that the vascular access device market in ... India and China (BRIC) ... the size of the United States market ... faster growth as a result of strong economic expansion, improving access ... from Decision Resources Group,s coverage of the BRIC vascular access device ...
(Date:8/20/2014)... SAN JOSE, Calif. , Aug. 20, 2014 ... UCSD highlights the transformative collaboration between the school,s ... (IoT).  As part of the Intel® Software Academic ... between computer sciences and the human body.  ... The study exhibits the work of ...
(Date:8/19/2014)... One of the major limitations in ... vascular supply. Nutrient and gas transport throughout synthetic ... for successful regeneration and integration into the patient’s ... vascularization and promote angiogenesis in a variety of ... and architecture, and enhancing scaffolds with stem cells. ...
(Date:8/19/2014)... August 19, 2014 Cellgen ... raise $200,000 to fund a corporate lab for ... , This development is a critical component in ... care to the implementation of personalized medicine – ... practicing medicine. , Indiegogo contributions will support Cellgen’s ...
Breaking Biology Technology:BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3
... 6, 2012 Arteriocyte, a leading biotechnology company ... announced today approval from the Food and Drug ... trial using its Magellan MAR01™ technology in the ... Exemption (IDE 15013) allows Arteriocyte and its clinical ...
... clusters of pancreatic beta-cells that live much longer and secrete ... valuable new tools for studying pancreatic diseases such as diabetes ... in an article in Tissue Engineering, Part C, Methods ... . The article is available free online at the ...
... dose of carbon nanotubes more than doubles the growth ... production of everything from lifesaving medications to sweeteners to ... the first to show that carbon nanotubes boost plant ... ACS Nano . Mariya V. Khodakovskaya and colleagues ...
Cached Biology Technology:Arteriocyte Receives FDA Approval to Initiate Compartment Syndrome Trial for Amputation Prevention Focused on Wounded Warriors 2Arteriocyte Receives FDA Approval to Initiate Compartment Syndrome Trial for Amputation Prevention Focused on Wounded Warriors 3
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Request Info...
QML offers standard and customized paraffin embedded tissue blocks....
Request Info...
Biology Products: