Navigation Links
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
Date:6/2/2011

PASADENA, Calif.In many ways, life is like a computer. An organism's genome is the software that tells the cellular and molecular machinerythe hardwarewhat to do. But instead of electronic circuitry, life relies on biochemical circuitrycomplex networks of reactions and pathways that enable organisms to function. Now, researchers at the California Institute of Technology (Caltech) have built the most complex biochemical circuit ever created from scratch, made with DNA-based devices in a test tube that are analogous to the electronic transistors on a computer chip.

Engineering these circuits allows researchers to explore the principles of information processing in biological systems, and to design biochemical pathways with decision-making capabilities. Such circuits would give biochemists unprecedented control in designing chemical reactions for applications in biological and chemical engineering and industries. For example, in the future a synthetic biochemical circuit could be introduced into a clinical blood sample, detect the levels of a variety of molecules in the sample, and integrate that information into a diagnosis of the pathology.

"We're trying to borrow the ideas that have had huge success in the electronic world, such as abstract representations of computing operations, programming languages, and compilers, and apply them to the biomolecular world," says Lulu Qian, a senior postdoctoral scholar in bioengineering at Caltech and lead author on a paper published in the June 3 issue of the journal Science.

Along with Erik Winfree, Caltech professor of computer science, computation and neural systems, and bioengineering, Qian used a new kind of DNA-based component to build the largest artificial biochemical circuit ever made. Previous lab-made biochemical circuits were limited because they worked less reliably and predictably when scaled to larger sizes, Qian explains. The likely reason behind this limitation is that such ci
'/>"/>

Contact: Deborah Williams-Hedges
debwmh@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. 2011 HFSP Nakasone Award for Michael Elowitz of Caltech
2. Young Caltech engineers recognized for innovative work in disease diagnostic technologies
3. Tip sheet: Caltech researchers presenting at AAAS
4. Caltech-led team creates damage-tolerant metallic glass
5. Caltech scientists describe the delicate balance in the brain that controls fear
6. NIH awards $11.5 million for new Caltech-led membrane-protein center
7. Caltech chemists develop simple technique to visualize atomic-scale structures
8. Fruit flies use horizontal landmarks for altitude control, says Caltech research team
9. Caltech: Gain and loss in optimistic versus pessimistic brains
10. Caltech biologists discover how T cells make a commitment
11. East-African human ancestors lived in hot environments, says Caltech-led team
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
(Date:9/16/2014)... tree species has its own bacterial identity. That,s the ... other institutions who studied the genetic fingerprints of bacteria ... island. , "This study demonstrates for the first time ... different ecological strategies possess very different microbial communities on ... former postdoctoral researcher in the UO,s Institute of Ecology ...
(Date:9/16/2014)... interaction between viruses, bacteria, and their environment is ... collaboration between Matthew Sullivan, associate professor in the ... Biology and Steven Hallam from the University of ... are drivers of nutrient and energy cycles that ... is changing, so are the environments these bacteria ...
(Date:9/16/2014)... a peacock show its extravagant, colorful tail feathers in ... have used a special camera developed by an engineer ... female northern swordtail fish choose their mates based on ... of Texas at Austin used a bioinspired polarization camera ... science & engineering at Washington University, to make the ...
Breaking Biology News(10 mins):Microbiome research shows each tree species has a unique bacterial identity 2New research decodes virus-host interactions in ocean dead zones 2New research decodes virus-host interactions in ocean dead zones 3Camera developed at WUSTL sheds light on mate choice of swordtail fish 2
... Our body,s activity levels fall and rise to the beat ... functions, from sleeping and feeding patterns to the energy available ... is set by light, the pacemakers in peripheral organs are ... Now, researchers at the Salk Institute for Biological ...
... Conference on Molecular Targets and Cancer Therapeutics is the ... therapies. This year,s conference brings together delegates from all ... target selection and the impact of new discoveries in ... plan your coverage of the conference, the program schedule ...
... long been recognized as essential to the advancement of ... knowledge in collaborative settings has been studied for some ... in collaborations established and maintained through virtual organizations. ... of New York (CCNY) is studying how virtual organizations, ...
Cached Biology News:The food-energy cellular connection revealed 2The food-energy cellular connection revealed 3CCNY researchers study scientific collaboration in age of internet 2
(Date:9/17/2014)... , September 17, 2014 ... of action from a truly novel class ... MGB Biopharma, a biopharmaceutical company developing ... today that it has secured £4.0m ($6.4m) ... antibacterial, MGB-BP-3, against a range of Gram-positive ...
(Date:9/16/2014)... Sept. 16, 2014 This report analyzes the worldwide ... Segments: Software, Hardware, and Biocontent. The report provides separate comprehensive ... Japan , Europe , ... and Rest of World. Annual estimates and forecasts are provided ... analysis is provided for these markets. Market data and analytics ...
(Date:9/16/2014)... University scientists who created a deicing film for radar ... a transparent coating for glass. , The new ... could keep glass surfaces from windshields to skyscrapers free ... radio frequencies (RF). , The technology was introduced ... Applied Materials and Interfaces . , The material ...
(Date:9/16/2014)...  The Council for Entrepreneurial Development (CED), the ... country, today released a mid-year update to its ... It showed that in the first half of ... in the technology, life science, advanced manufacturing and ... variety of sources. Significant investment in technology companies and ...
Breaking Biology Technology:MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23Nanoribbon film keeps glass ice-free 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4
... NanoSmart™ Pharmaceuticals, Inc., a California corporation developing novel biopharmaceuticals, ... Notice of Allowance for a US patent on its ... taken an approach to targeting tumors that is different ... the company. "While most of cancer research has focused ...
... Applied Precision, along with Indiana University, are ... DeltaVision|OMX imaging system in the Light Microscopy Imaging ... is a ground-breaking, three dimensional, super-resolution microscopy system ... traditional light microscopy. This super-resolution capability is especially ...
... Results -- HARBIN, China, Aug. 16 /PRNewswire-Asia-FirstCall/ -- ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in ...
Cached Biology Technology:NanoSmart™ Pharmaceuticals, Inc. Receives Patent Allowance for Tumor Targeting Platform Technology 2Applied Precision Installs New DeltaVision|OMX® Super-Resolution Imaging System in the Light Microscopy Imaging Center at Indiana University 2Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 2Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 3Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 4Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 5Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 6Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 7Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 8Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 9Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 10Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 11Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 12Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 13Weikang Bio-Technology Reports Second Quarter 2010 Financial Results 14