Navigation Links
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
Date:6/2/2011

PASADENA, Calif.In many ways, life is like a computer. An organism's genome is the software that tells the cellular and molecular machinerythe hardwarewhat to do. But instead of electronic circuitry, life relies on biochemical circuitrycomplex networks of reactions and pathways that enable organisms to function. Now, researchers at the California Institute of Technology (Caltech) have built the most complex biochemical circuit ever created from scratch, made with DNA-based devices in a test tube that are analogous to the electronic transistors on a computer chip.

Engineering these circuits allows researchers to explore the principles of information processing in biological systems, and to design biochemical pathways with decision-making capabilities. Such circuits would give biochemists unprecedented control in designing chemical reactions for applications in biological and chemical engineering and industries. For example, in the future a synthetic biochemical circuit could be introduced into a clinical blood sample, detect the levels of a variety of molecules in the sample, and integrate that information into a diagnosis of the pathology.

"We're trying to borrow the ideas that have had huge success in the electronic world, such as abstract representations of computing operations, programming languages, and compilers, and apply them to the biomolecular world," says Lulu Qian, a senior postdoctoral scholar in bioengineering at Caltech and lead author on a paper published in the June 3 issue of the journal Science.

Along with Erik Winfree, Caltech professor of computer science, computation and neural systems, and bioengineering, Qian used a new kind of DNA-based component to build the largest artificial biochemical circuit ever made. Previous lab-made biochemical circuits were limited because they worked less reliably and predictably when scaled to larger sizes, Qian explains. The likely reason behind this limitation is that such ci
'/>"/>

Contact: Deborah Williams-Hedges
debwmh@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. 2011 HFSP Nakasone Award for Michael Elowitz of Caltech
2. Young Caltech engineers recognized for innovative work in disease diagnostic technologies
3. Tip sheet: Caltech researchers presenting at AAAS
4. Caltech-led team creates damage-tolerant metallic glass
5. Caltech scientists describe the delicate balance in the brain that controls fear
6. NIH awards $11.5 million for new Caltech-led membrane-protein center
7. Caltech chemists develop simple technique to visualize atomic-scale structures
8. Fruit flies use horizontal landmarks for altitude control, says Caltech research team
9. Caltech: Gain and loss in optimistic versus pessimistic brains
10. Caltech biologists discover how T cells make a commitment
11. East-African human ancestors lived in hot environments, says Caltech-led team
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
(Date:7/30/2014)... by the Red Queen in Lewis Carroll,s Through ... Illinois and National University of Singapore improved a ... evolve over decades to millions of years. , ... for competition, incorporates the "Red Queen Effect," an ... the 1970s, which suggests that organisms must constantly ...
(Date:7/30/2014)... effects of climate change on the world,s animal ... factors, according to a new paper by a ... of Queensland, and other organizations. The authors claim ... the point when it comes to climate change. ... scientists focus on the "direct" threats of changing ...
(Date:7/30/2014)... A group of researchers from the University of Helsinki ... experimentally to reproduce in mice morphological changes which have ... gradual modifications in the embryonic development of mice teeth, ... morphologically are very similar to those observed in the ... millions of years ago. , To modify the ...
Breaking Biology News(10 mins):Classic Lewis Carroll character inspires new ecological model 2Classic Lewis Carroll character inspires new ecological model 3Conservation scientists asking wrong questions on climate change impacts on wildlife 2Scientists reproduce evolutionary changes by manipulating embryonic development of mice 2
... Conn. A missing link in the evolution of the ... with the discovery of a 390 million-year-old fossil by researchers ... specimen, named Schinderhannes bartelsi , was found fossilized in ... that yields spectacularly durable pyrite-preserved fossils findings collectively known ...
... of a new species of fruit fly--and the sequential development ... of the journal Science . Jeff Feder, a ... introduction of apples to America almost 400 years ago ultimately ... to its modification and the subsequent modification of a parasitic ...
... the National Science Foundation (NSF) will host its 8th ... This year,s forum focuses on ecological connectivity and climate. ... an ecological context, connectivity is defined as the transfer ... animals among interconnected locations. In this symposium, LTER ...
Cached Biology News:Origin of claws seen in 390-million-year-old fossil 2Researchers observe evolution chain reaction 2National Science Foundation forum to address ecological connectivity and climate in a changing world 2
(Date:7/31/2014)... Sales Horizons, a leader in sales training, today ... – Mastering the Complex Sale – to ... proven sales training programs used by thousands of salespeople ... sales training course is available to every salesperson as ... customers, like technical support, engineers, clinical support, and IT ...
(Date:7/30/2014)... and PARIS , July 30, 2014 ... SAN and NYSE: SNY) today announced that the Companies ... (FDA) rare pediatric disease priority review voucher in connection ...  The priority review voucher entitles the holder to designate ... expedited 6-month review from the filing date instead of ...
(Date:7/30/2014)... Mass. , July 30, 2014  Decision ... pharmacy and medical directors in the ... drivers of biosimilar market penetration will be the ... organizations (MCOs) and the expected lower cost to ... for biosimilars that meet their pricing expectations in ...
(Date:7/30/2014)... , July 30, 2014  The Chicago Bears ... American Academy of Dermatology (Academy) in an effort to ... Chicago Bears will host free SPOT me™ skin cancer ... 2 at Soldier Field. SPOT me™ is an ... about the dangers and risks of skin cancer, and ...
Breaking Biology Technology:Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 3Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 2Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 3Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 4
... Pfizer Cox-2 inhibitor Bextra from the marketplace clearly jolted both Pfizer ... Vioxx dilemma months ago and its stock has declined from $38 ... February. It has recently moved up to the $27 level. , ... the last 12 months. , ,Though Pfizer still leads the industry ...
... Milwaukee Badger Meter Inc. (AMEX:BMI) reported ... the quarter ended March 31, a profit jump of 42 ... metering products for water systems, including a wireless display that ... for the same quarter last year were $2.4 million, on ...
... (NYSE:SXT) reported $12.8 million in profits on $251.9 million ... earnings per share were 27 cents. Sensient is a global ... was down $3 million since the same quarter last year. ... , ,Results for the first quarter include a one-time expense ...
Cached Biology Technology:Why are new drugs failing? 2Why are new drugs failing? 3Why are new drugs failing? 4Why are new drugs failing? 5Why are new drugs failing? 6
... Super Sensitive Polymer-HRP IHC ... novel product based on ... technology. This system yields ... noise ratio and minimizes ...
... The Gene Cycler unit is an inexpensive ... licensed for the PCR process. Lightweight, with a ... fits almost anywhere, including the researcher's desk. , ... of researchers who do not have access to ...
... FLISP Assay with SR-101 Labeled Substrates ... • Accurately measure serine protease activation ... • B-Bridge's FLISP Kits utilize cell-permeable, ... (FLISPs) to measure chymotrypsin-like activity in ...
... the PDS-1000 He biolistic system enables 7-10 times ... system. It fits into the shocking chamber of ... helium shock wave over 7 microcarriers. By uniformly ... this larger area, the system maximizes the number ...
Biology Products: