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Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
Date:3/21/2010

cancer," adds coauthor Yun Yen, associate director for translational research at City of Hope. "We are seeing for the first time the utility of siRNA as a cancer therapy and how nanotechnology can target cancer cells specifically."

The Phase I trialsponsored by Calando Pharmaceuticalsis proceeding at START and UCLA's Jonsson Comprehensive Cancer Center, and the clinical results of the trial will be presented at a later time. "At the very least, we've proven that the RNAi mechanism can be used in humans for therapy and that the targeted delivery of siRNA allows for systemic administration," Davis says. "It is a very exciting time."


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Contact: Jon Weiner
jrweiner@caltech.edu
626-395-3226
California Institute of Technology
Source:Eurekalert  

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